Skip to main content
SpringerLink
Log in

Investigations of genotoxic activity of antimicrobial/antiviral agent FS-1 in human lymphocytes and tumor cell

  • Published:
Cytology and Genetics Aims and scope Submit manuscript

Abstract

A very promising antiviral and antimicrobial agent FS-1 was studied for its ability to induce DNA damage and micronuclei in human tumor cell lines HeLa and Caco-2 at concentrations of 200, 500 and 1000 μg/ml without exogenous metabolic activation. The compound was additionally tested for DNA damaging ability in human lymphocytes at concentrations of 200, 400 and 800 μg/ml. Neither DNA damage nor micronucleus formation was observed after treatment of all types of cells with FS-1. Based on these results, FS-1 can be further studied for its safety to humans for potential application in clinical medicine as an antimicrobial/antiviral drug.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gluck, U., Martin, U., Bosse, B., Reimer, K., and Mueller, S., A Clinical Study on the Tolerability of a Liposomal Povidone-Iodine Nasal Spray: Implications for Further Development, ORL J. Otorhinolar. Relat. Spec., 2007, vol. 69, pp. 92–99.

    Article  CAS  Google Scholar 

  2. Davtyan, T.K., Mkhitaryan, L.M., and Gabrielyan, E.S., Design of Iodine-Lithium-Alpha-Dextrin Liquid Crystal with Potent Antimicrobial and Anti-Inflammatory Properties, Curr. Pharm. Des., 2009, vol. 15, pp. 1172–1186.

    Article  PubMed  CAS  Google Scholar 

  3. Nersesyan, A., Muradyan, R., Arsenyan, F., and Danagulyan, G., Micronucleus-Inducing and Antitumor Activity of Three Newly Synthesized Bridged Nitrogen Atom-Containing Pyrrolidines, J. B.U.ON, 2006, vol. 11, pp. 329–334.

    CAS  Google Scholar 

  4. Nersesyan, A.K. and Collins, A.R., Possible Genotoxic Activity of Extracts of Bryonia Alba Roots on Human Lymphocytes and Transformed Cells, Neoplasma, 2002, vol. 49, pp. 114–116.

    PubMed  CAS  Google Scholar 

  5. Brambilla, G. and Martelli, A., Genotoxicity and Carcinogenicity Studies of Analgesics, Anti-Inflammatory Drugs and Antipyretics, Pharmacol. Res., 2009, vol. 60, pp. 1–17.

    Article  PubMed  CAS  Google Scholar 

  6. Kirsch-Volders, M., Sofuni, T., Aardema, M., Albertini, S., Eastmond, D., Fenech, M., Ishidate, M., Kirchner, S., Lorge, E., Morita, T., Norppa, H., Surralles, J., Vanhauwaert, A., and Wakata, A., Report from the in Vitro Micronucleus Assay Working Group, Mutat. Res., 2003, vol. 540, pp. 153–163.

    PubMed  CAS  Google Scholar 

  7. Lorenzo, Y., Azqueta, A., Luna, L., Bonilla, F., Dominguez, G., and Collins, A.R., The Carotenoid Beta-Cryptoxan-Thin Stimulates the Repair of DNA Oxidation Damage in Addition to Acting as an Antioxidant in Human Cells, Carcinogenesis, 2009, vol. 30, pp. 308–314.

    Article  PubMed  CAS  Google Scholar 

  8. Collins, A.R., Assays for Oxidative Stress and Antioxidant Status: Applications to Research Into the Biological Effectiveness of Polyphenols, Am. J. Clin. Nutr., 2005, vol. 81,suppl. 1, pp. 261S–267S.

    PubMed  CAS  Google Scholar 

  9. Faust, F., Kassie, F., Knasmuller, S., Kevekordes, S., and Mersch-Sundermann, V., Use of Primary Blood Cells for the Assessment of Exposure to Occupational Genotoxicants in Human Biomonitoring Studies, Toxicology, 2004, vol. 198, pp. 341–350.

    Article  PubMed  CAS  Google Scholar 

  10. Ciolino, H.P., Bass, S.E., MacDonald, C.J., Cheng, R.Y., and Yeh, G.C., Sulindac and Its Metabolites Induce Carcinogen Metabolizing Enzymes in Human Colon Cancer Cells, Int. J. Cancer, 2008, vol. 122, pp. 990–998.

    Article  PubMed  CAS  Google Scholar 

  11. Pohl, C., Will, F., Dietrich, H., and Schrenk, D., Cytochrome P450 1A1 Expression and Activity in Caco-2 Cells: Modulation by Apple Juice Extract and Certain Apple Polyphenols, J. Agric. Food Chem., 2006, vol. 54, pp. 10262–10268.

    Article  PubMed  CAS  Google Scholar 

  12. Raucy, J.L., Schultz, E.D., Wester, M.R., Arora, S., Johnston, D.E., Omdahl, J.L., and Carpenter, S.P., Human Lymphocyte Cytochrome P450 2E1, a Putative Marker for Alcohol-Mediated Changes in Hepatic Chlorzoxazone Activity, Drug Metab. Dis., 1997, vol. 25, pp. 1429–1435.

    CAS  Google Scholar 

  13. Kessler, F.K., Laskin, D.L., Borzelleca, J.F., and Carchman, R.A., Assessment of Somatogenotoxicity of Povidone-Iodine using Two in vitro Assays, J. Environ. Pathol. Toxicol., 1980, vol. 3, pp. 327–335.

    Google Scholar 

  14. Merkle, J. and Zeller, H., Absence of Povidone-Iodine-Induced Mutagenicity in Mice and Hamsters, J. Pharm. Sci., 1979, vol. 68, pp. 100–102.

    Article  PubMed  CAS  Google Scholar 

  15. Rosenkranz, H.S., Gutter, B., and Speck, W.T., Mutagenicity and DNA-Modifying Activity: A Comparison of Two Microbial Assays, Mutat. Res., 1976, vol. 41, pp. 61–70.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Center of Oncology, Yerevan, Armenia

    A. Nersesyan

  2. Institute of Cancer Research, Medical University of Vienna, Vienna, Austria

    A. Nersesyan

  3. Scientific Center for Anti-Infectious Drugs, Almaty, Kazakhstan

    A. Ilin & M. Kulmanov

Authors
  1. A. Nersesyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Ilin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Kulmanov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Nersesyan.

Additional information

The article is published in the original.

About this article

Cite this article

Nersesyan, A., Ilin, A. & Kulmanov, M. Investigations of genotoxic activity of antimicrobial/antiviral agent FS-1 in human lymphocytes and tumor cell. Cytol. Genet. 45, 70–74 (2011). https://doi.org/10.3103/S0095452711020101

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.3103/S0095452711020101

Keywords

Search

Navigation