Skip to main content
SpringerLink
Log in

Chiral mutagens: Cytogenetic effects on higher plants

  • Published:
Cytology and Genetics Aims and scope Submit manuscript

Abstract

The cytogenetic activity of chiral nitrosoalkilureas and their effect on winter soft wheat chromosomes (Triticum aestivum L.) have been investigated. A comparative analysis of the cytogenetic activity of the chiral nitrosoalkilureas—S(+)1-N-nitroso-1-N-methyl-3-N-sec-buthylurea (S(+)NMsBU) and R(−)-1-N-nitroso-1-N-methyl-3-N-sec-buthylurea (R(−)NMsBU)—on higher plants has been performed for the first time. According to the frequency of chromosome aberrations, stereoisomers S(+) are twice more active than stereoisomers R(−). In addition to the typical anaphase aberrations (fragments, bridges, and lagging chromosomes), other numerous mitosis pathologies have been found: C-mitosis, chromosome hyperspiralization and despiralization, unequal chromosome allocation between daughter nuclei, three-pole mitosis, etc. Such pathologies have not been found when treating with nitrosoethylurea and gamma rays.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rapoport, I.A., Carbonyl Compounds and Chemical Mechanism of Mutations, Dokl. Akad. Nauk SSSR, 1946, vol. 54, no. 1, pp. 65–68.

    CAS  Google Scholar 

  2. Auerbach, C. and Robson, J.V., Chemical Production of Mutations, Nature, 1946, vol. 157, p. 302.

    Article  PubMed  CAS  Google Scholar 

  3. Lawley, P.D., Orr, D.J., and Jarman, M., Isolation and Identification of Products from Alkylation of Nucleic Acids: Ethyl- and Isopropyl-Purines, Biochem. J., 1975, vol. 145, no. 1, pp. 73–84.

    PubMed  CAS  Google Scholar 

  4. Natarajan, A.T., Simons, J.W.I.M., Vogel, E.W., and Van Zeeland, A.A., Relationship between Cell Killing, Chromosomal Aberrations, Sister-Chromatid Exchanges and Point Mutations Induced by Monofunctional Alkylating Agents in Chinese Hamster Cells a Correlation with Different Ethylation Products in DNA, Mutat. Res., 1984, vol. 128, pp. 31–40.

    PubMed  CAS  Google Scholar 

  5. Nalarajan, A.T., Chemical Mutagenesis: From Plants to Human, Curr. Sci., 2005, vol. 89, no. 2, pp. 312–317.

    Google Scholar 

  6. Rapoport, I.A., Izbrannye trudy. Otkrytie khimicheskogo mutageneza (Selected Papers. The Discovery of Chemical Mutagenesis), Moscow: Nauka, 1993.

    Google Scholar 

  7. Kalaidzhyan, A.A., Khlevnoi, L.V., Neshchadim, N.N., et al., Rossiiskii solnechnyi tsvetok (Russian Sun Flower), Krasnodar: Sov. Kuban’, 2007.

    Google Scholar 

  8. Vasilenko, V.N., Grabovets, A.I., Timarenko, A.I., et al., Sorta polevykh kul’tur (Varieties of Field Crops), Rostov-on-Don, 2009.

  9. Morgun, V.V. and Logvinenko, V.F., Mutatsionnaya selektsiya pshenitsy (Mutation Breeding of Wheat), Kiev: Naukova dumka, 1995.

    Google Scholar 

  10. Shafique, S., Bajwa, R., and Shafique, S., Mutation of Alternaria temuissima FCBP-252 for Hyper-Active-Amylase, Indian J. Exp. Biol., 2009, vol. 47, pp. 591–596.

    PubMed  CAS  Google Scholar 

  11. Nuclear Safety Review for the Year 2009 IAEA/NSR/2009. Printed in the IAEA in Austria July 2010, http://www.iaea.org/Publications/Reports/index.html.

  12. Larchenko, E.A., Study of Mutagenic Activity of Chemical Compounds from the Classes Nitrozoalkyl-Ureas and Diazoketones in Maize, Extended Abstract of Cand. Sci. (Biol.) Dissertation, Kiev, 1976.

  13. Morgun, V.V., Spontaneous and Induced Mutational Variability and Its Use in Plant Breeding, in Genetics and Breeding in Ukraine at the Turn of the Millennia, Kyiv: Logos, 2001, vol. 2, pp. 144–174.

    Google Scholar 

  14. Rapoport, I.A. and Kostyanovskii, R.G., Mutational Activity of Some Cholinesterase Inhibitors, Dokl. Akad. Nauk SSSR, 1960, vol. 131, no. 1, p. 191.

    CAS  Google Scholar 

  15. Rauk, A., Shishkov, I.F., Vilk, L.V., Koehler, K.F., and Kostyanovsky, R.G., Structure and Chiroptical Properties of the Parent Nerve Gas—Methoxy Methylphosphonofluoridate—by ab initio Calculations, Electron Diffraction Analysis and NMR Spectroscopy, J. Am. Chem. Soc., 1995, vol. 117, no. 27, pp. 7180–7185.

    Article  CAS  Google Scholar 

  16. Anderson, T., McMenamin, M.G., and Schein, P.S., Chlorozotocin 2-(3-(2-Chlorozoethyl)-3-Nitrosoureido)-D-Glucopyranose, an Antitumor Agent with Modified Bone Marrow Toxicity, Cancer Res., 1975, vol. 35, no. 3, pp. 761–765.

    PubMed  CAS  Google Scholar 

  17. Isobe, M. and Yano, K., Comparison of Mutagenicity and Chemical Properties of N-Methyl-N’-Alkyl-N-Nitrosoureas, Mutat. Res., 1982, vol. 93, pp. 57–66.

    PubMed  CAS  Google Scholar 

  18. Zoz, N.N., Khimicheskii mutagenez u vysshikh rastenii. Supermutageny (Chemical Mutagenesis in Higher Plants. Supermutagens), Moscow: Nauka, 1966.

    Google Scholar 

  19. Pausheva, Z.P., Praktikum po tsitologii rastenii (A Practical Course in Plant Cytology), Moscow: Agropromizdat, 1988.

    Google Scholar 

  20. Auerbakh, Sh., Problemy mutageneza (Problems of Mutagenesis), Moscow: Mir, 1978.

    Google Scholar 

  21. Dubinin, N.P., Genetika (Genetics), Chisinau: Shtiintsa, 1985.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Plant Physiology and Genetics, National Academy of Sciences of Ukraine, Kiev, Russia

    V. V. Morgun, E. A. Larchenko & A. M. Katerynchuk

  2. Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    R. G. Kostyanovskiy

Authors
  1. V. V. Morgun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. A. Larchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. G. Kostyanovskiy
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. M. Katerynchuk
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. M. Katerynchuk.

Additional information

Original Russian Text © V.V. Morgun, E.A. Larchenko, R.G. Kostyanovskiy, A.M. Katerynchuk, 2011, published in Tsitologiya i Genetika, 2011, Vol. 45, No. 4, pp. 36–43.

About this article

Cite this article

Morgun, V.V., Larchenko, E.A., Kostyanovskiy, R.G. et al. Chiral mutagens: Cytogenetic effects on higher plants. Cytol. Genet. 45, 231–239 (2011). https://doi.org/10.3103/S0095452711040074

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.3103/S0095452711040074

Keywords

Search

Navigation