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Assessment of the relationship between combinations of polymorphic variants of xenobiotic-metabolizing enzyme genes and predisposition to lung cancer

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Abstract

An imbalance between the phases of biotransformation systems, such as activation, detoxification, and release of toxic substances, is one of the causes of multifactor pathology. Therefore, it is important to examine the impact of the total contribution of the polymorphic variants of xenobiotic-metabolizing enzyme genes at all three phases on predisposition to lung cancer. The purposes of the present work were to study the relationship between polymorphic variants of xenobiotic-metabolizing enzyme genes and risk of lung cancer and to identify molecular genetic markers of predisposition to the disease. It was shown that GSTT1 null-genotype plays a dominant role in the development of lung cancer predisposition in the Belarusian population, while the polymorphic variants of other genes of xenobiotic-metabolizing enzymes render a modifying effect on predisposition to this disease. Combination 734AA CYP1A2/GSTT1(−)/GSTM1(+)/“slow” acetylator has the greatest risk significance, and combination GSTT1(−)/GSTM1(+)/“slow” acetylator exerts a protective effect.

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Authors and Affiliations

  1. Institute of Genetics and Cytology, National Academy of Sciences of Belarus, ul. Akademicheskaya 27, Minsk, 220072, Belarus

    A. P. Mikhalenko, E. V. Krupnova, N. N. Chakova & N. V. Chebotareva

  2. Belarusian Medical Academy of Postgraduate Education, ul. P. Brovki 3/3, Minsk, 220013, Belarus

    Yu. E. Demidchik

Authors
  1. A. P. Mikhalenko
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  2. E. V. Krupnova
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  3. N. N. Chakova
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  4. N. V. Chebotareva
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  5. Yu. E. Demidchik
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Correspondence to A. P. Mikhalenko.

Additional information

Original Russian Text © A.P. Mikhalenko, E.V. Krupnova, N.N. Chakova, N.V. Chebotareva, Yu.E. Demidchik, 2014, published in Tsitologiya i Genetika, 2014, Vol. 48, No. 2, pp. 52–59.

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Mikhalenko, A.P., Krupnova, E.V., Chakova, N.N. et al. Assessment of the relationship between combinations of polymorphic variants of xenobiotic-metabolizing enzyme genes and predisposition to lung cancer. Cytol. Genet. 48, 111–116 (2014). https://doi.org/10.3103/S009545271402008X

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  • DOI: https://doi.org/10.3103/S009545271402008X

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