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The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility

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Abstract

Toll-like receptors (TLRs) play an important role in the induction and regulation of the innate immune system or adaptive immune responses. Genetic variations within human TLRs have been reported to be associated with rheumatoid arthritis (RA). This study was conducted to investigate correlation between SNP of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of RA. There was obviously correlative between single nucleotide polymorphism and predisposing genes of RA. G-type of IL-1RAP rs766442 may be protecting genes of RA, while T-type alleles of IL-6R rs11265618 and IL-1RAP rs766442 may be susceptible genes of RA. In conclusion, the studies on the nucleis acid polymorphism in TLRs signal pathway contribute to disclose genes’ influence on the attack mechanism of RA, early diagnosis and treatment of RA.

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Authors and Affiliations

  1. Department of Rheumatology, Shandong Provincial Hospital, Shandong University, Jingwu Road 324, Jinan, 250021, China

    X. Liu, J. Xu, Z. L. Pan & Y. C. Zhang

  2. Department of Osteology, Handan Central Hospital, Zhonghua st. 35, Handan, 056001, China

    C. D. Hu

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  1. X. Liu
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  2. J. Xu
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  3. C. D. Hu
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  4. Z. L. Pan
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  5. Y. C. Zhang
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Correspondence to Y. C. Zhang.

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Liu, X., Xu, J., Hu, C.D. et al. The relationship between SNPS in the genes of TLR signal transduction pathway downstream elements and rheumatoid arthritis susceptibility. Cytol. Genet. 48, 155–159 (2014). https://doi.org/10.3103/S0095452714030074

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