Skip to main content
SpringerLink
Log in

Analysis of molecular genetic study on the polymorphic C-159T locus of the CD14 gene in children with increased risk of recurrent episodes of acute obstructive bronchitis

  • Published:
Cytology and Genetics Aims and scope Submit manuscript

Abstract

A molecular genetic study of the polymorphic C-159T locus of the CD14 gene has been carried out in 31 children with recurrent episodes of acute obstructive bronchitis as well as in a cohort of 50 randomly sampled subjects forming the control group. As a result of the study, no higher statistically significant frequency of the CC, CT, and TT genotypes has been recorded at the polymorphic C-159T locus of the CD14 gene among children of the main group compared with the control. However, there is a trend towards a more frequent observation of the TT genotype among children with recurrent episodes of acute obstructive bronchitis compared with the control group (32.25 vs. 22.0%).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yurtseva, A.P., Fofanova, O.V., Osadets, N.B., and Bodnar, O.P., Efficiency of Laferobion treatment of children with bronchoobstructive syndrome who suffer from recurrent wheezing, Zdorov’e Rebenka, 2014, vol. 56, no. 5, pp. 21–26.

    Google Scholar 

  2. Krishnan, A., Amarchand, R., Gupta, V., Lafond, K.E., Suliankatchi, R.A., Saha, S., Rai, S., Misra, P., Purakayastha, D.R., Wahi, A., Sreenivas, V., Kapil, A., Dawood, F., Pandav, C.S., Broor, S., Kapoor, S.K., Lal, R., and Widdowson, M.A., Epidemiology of acute respiratory infections in children—preliminary results of a cohort in a rural north Indian community, BMC Infect. Dis., 2015, no.15:462, doi 10.1186/s12879-015-1188-1

    Google Scholar 

  3. Selvaraj, K., Chinnakali, P., Majumdar, A., and Krishnan, I.S., Acute respiratory infections among under-5 children in India: a situational analysis, J. Nat. Sci., Biol. Med., 2014, vol. 5, no. 1, pp. 15–20.

    Article  Google Scholar 

  4. Liu, W.K., Liu, Q., Chen, D.H., Liang, H.X., Chen, X.K., Chen, M.X., Qiu, S.Y., Yang, Z.Y., and Zhou, R., Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study, PLoS One, 2014, vol. 9, no. 5, p. e96674.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Ustinov, A.V., Principles of diagnosis and treatment of acute respiratory diseases, Ukr. Med. Chasopis, 2010, no. 6 (80), pp. 3–7.

    Google Scholar 

  6. Mandal, A., Kabra, S., and Lodha, R., Upper airway obstruction in children, Indian J. Pediatr., 2015, vol. 82, no. 8, pp. 737–744.

    Article  PubMed  Google Scholar 

  7. Zaytseva, O.V., and Zaytseva, S.V., Bronchial asthma and respiratory infections in children, Vestn. Pediatr. Farmakol. Nutritsiol., 2008, vol. 5, no. 1, pp. 54–60.

    Google Scholar 

  8. Smith, F., and Goldman, R.D., Nebulizers versus pressurized metered-dose inhalers in preschool children with wheezing, Can. Fam. Physician., 2012, vol. 58, no. 5, pp. 528–530.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Osipova, L.S., Characteristics of application of interferon preparations in clinical practice, Mistetstvo Likuvannya, 2011, no. 2 (78), pp. 70–73.

    Google Scholar 

  10. Gorenkov, R.V., Acute respiratory infections and influenza— methods of struggle, Lech. Vrach, 2012, no. 3, pp. 9–12.

    Google Scholar 

  11. Ivardava, M.I., Place immunomodulators in the treatment of acute respiratory infections in children, who often get sick, Vopr. Sovrem. Pediatr., 2011, vol. 10, no. 3, pp. 103–107.

    Google Scholar 

  12. Zielinska, O.D., Kryvov’yaz, T.N., and Shkarpeta, S.A., The problem of sickly children of preschool age, Biomed. Biosoc. Anthropol., 2010, no. 15, pp. 269–272.

    Google Scholar 

  13. Duka, K.D., Discussion questions immunocorrection with recurrent respiratory diseases, Zdorov’e Rebenka, 2008, no. 7(50), pp. 23–27.

    Google Scholar 

  14. Zaykov, S.V., and Grishylo, P.V., Experience of bacterial lysates application in treatment of respiratory diseases, Astma Allerg., 2013, no. 3, pp. 66–71.

    Google Scholar 

  15. Tang, H., Fang, Z., and Xiu, Q., Efficacy and safety of bacterial lysates in patients with chronic obstructive pulmonary diseases and exacerbation, Eur. Respir. J., 2011, vol. 38, suppl. 55, pp. 599.

    Google Scholar 

  16. Geppe, N.A., Ribosomal complex in prevention of frequent respiratory diseases in children, Farmateka, 2013, no. 1 (254), pp. 32–36.

    Google Scholar 

  17. Schaad, U.B., OM-85 BV, an immunostimulant in pediatric recurrent respiratory tract infections: a systematic review, World J. Pediatr., 2010, vol. 6, no. 1, pp. 5–12.

    Article  CAS  PubMed  Google Scholar 

  18. Ershova, I.V., Kunegina, EN., and Litus, V.I., The problems of acute respiratory diseases in pediatrics, Zdorov’e Ukraini, 2003, no. 21–23, pp. 33–35.

    Google Scholar 

  19. Samsygina, G.A., Frequently ill children: problems of pathogenesis, diagnosis and therapy, Pediatriya, 2005, no. 1, pp. 66–77.

    Google Scholar 

  20. Berezhnuy, V.V., Immunocorrection recurrent respiratory tract infections in children, Zdorov’e Ukraini (Tematich. Nomer), 2013, pp. 32–33.

    Google Scholar 

  21. Abaturov, A.E., Treatment of acute respiratory diseases with wheezing in younger children, Zdorov’e Ukraini, 2013, no. 1, pp. 49–54.

    Google Scholar 

  22. Cassano, M., Cassano, P., Luigi, M., Gelardi, M., Farras, A.C., and Fiorella, M.L., Rhino-bronchial syndrome in children: pathogenic correlations and clinical-experimental aspects, Int. J. Pediatr. Otorhinolaryngol., 2006, vol. 70, no. 3, pp. 507–513.

    Article  PubMed  Google Scholar 

  23. Katilov, A.V., Dmitriev, D.V., and Dmitrieva, E.Yu., Klinicheskaya pulmonologiya detskogo vozrasta (Clinical Pulmonology in Early Childhood), Vinnitsa, 2014.

    Google Scholar 

  24. Schultz, A., Devadason, S.G., Savenije, O.E., Sly P.D., Le Souёf, P.N., and Brand, P.L., The transient value of classifying preschool wheeze into episodic viral wheeze and multiple trigger wheeze, Acta Paediatr., 2010, vol. 99, no. 1, pp. 56–60.

    CAS  PubMed  Google Scholar 

  25. Zhdan, V.M., Hurina, L.I., and Babanina, M.Y., Respiratory Diseases in the Practice of Family Doctor, Poltava, 2008.

    Google Scholar 

  26. Bulgakova, V.A., Acute respiratory infections in frequently ill children: etiotropic role of the drug in the prevention and treatment, Pediatriya, 2013, no. 6, pp. 90–94.

    Google Scholar 

  27. Marushko, Y.V., Movchan, A.S., and Marushko, T.V., Functioning of local immunity and its characteristics in children who often suffer from respiratory infections, Ukr. Med. Chasopis, 2011, no. 1 (99), pp. 41–45.

    Google Scholar 

  28. Pfleger, A., and Eber, E., Management of acute severe upper airway obstruction in children, Paediatr. Respir. Rev., 2013, vol. 14, no. 2, pp. 70–77.

    Article  PubMed  Google Scholar 

  29. Laya, B.F., and Lee, E.Y., Congenital causes of upper airway obstruction in pediatric patients: updated imaging techniques and review of imaging findings, Semin. Roentgenol., 2012, vol. 47, no. 2, pp. 147–158.

    Article  PubMed  Google Scholar 

  30. Ciprandi, G., Schiavetti, I., Sorbello, V., and Ric-ciardolo, F.L., Perception of asthma symptoms as assessed on the visual analog scale in subjects with asthma: a real-life study, Respir. Care, 2015, vol. 61, no. 1, pp. 29–31.

    Google Scholar 

  31. Konstantellou, E., Papaioannou, A., Loukides, S., Patentalakis, G., Papaporfyriou, A., Hillas, G., Papiris, S., Koulouris, N., Bakakos, P., and Kostikas, K., Persistent airflow obstruction in patients with asthma: characteristics of a distinct clinical phenotype, Respir. Med., 2015, vol. 109, no. 11, pp. 1404–1409.

    Article  PubMed  Google Scholar 

  32. Kulus, M., Bronchial reactivity and initial airway status in asthmatic children, New Med., 2001, no. 1, pp. 42–47.

    Google Scholar 

  33. Garcia-Marcos, L., Mallol, J., Solé, D., Brand, P.L.; and EISL Study Group, International study of wheezing in infants: risk factors in affluent and non-affluent countries during the first year of life, Pediatr. Allergy Immunol., 2010, vol. 21, no. 5, pp. 878–888.

    Article  PubMed  Google Scholar 

  34. Soroka, Y.A., Wheezing in pediatric practice, Zdorov’e Rebenka, 2006, no. 21, pp. 2–4.

    Google Scholar 

  35. Zaykov, S.V., and Bogomolov, A.E., Modern approaches to laboratory diagnostics of allergies, Novosti Med. Farmats., 2013, no. 14, pp. 6–10.

    Google Scholar 

  36. Just, J., Gouvis-Echraghi, R., Couderc, R., Guillemot-Lambert, N., and Saint-Pierre, P., Novel severe wheezy young children phenotypes: boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze, J. Allergy Clin. Immunol., 2012, vol. 130, no. 1, pp. 103–105.

    Article  PubMed  Google Scholar 

  37. Canonica, G.W., Ansotegui, I.G., Pawankar, R., et al., A WAO-ARIA-GA2LEN consensus document on molecular-based allergy diagnostics study, World Allergy Organ. J., 2013, vol. 6, no. 1. doi 10.1186/1939-4551-6-17

    Google Scholar 

  38. Spycher, B.D., Silverman, M., and Kuehni, C.E., Phenotypes of childhood asthma: are they real?, Clin. Exp. Allergy, 2010, vol. 40, no. 1, pp. 1130–1141.

    Article  CAS  PubMed  Google Scholar 

  39. Lang, J.E., and Blake, K.V., Role of biomarkers in understanding and treating children with asthma: towards personalized care, Pharmgenomics Pers. Med., 2013, no. 6, pp. 73–84.

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Ginter, E.K., Meditsinskaya genetika (Medical Genetics), Moscow, 2003, 448 p.

    Google Scholar 

  41. Bersinbay, R.I., Akparova, A.Yu., and Baygenzhin, A.K., The role of genetic polymorphism in predisposition to bronchial asthma and recurrent wheezing, Vestnik ENU im. L.N. Gumileva, 2010, no. 4, pp. 401–411.

    Google Scholar 

  42. Pino-Yanes, M., Corrales, A., Cumplido, J., Poza, P., Sánchez-Machín, I., Sánchez-Palacios, A., Figueroa, J., Acosta-Fernández, O., Buset, N., García-Robaina, J.C., Hernández, M., Villar, J., Carrillo, T., and Flores, C., Assessing the validity of asthma associations for eight candidate genes and age at diagnosis effects, PLoS One, 2013, vol. 8, no. 9, p. e73157.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Ayaslioglu, E., Kalpaklioglu, F., Kavut, A.B., Er-turk, A., Capan, N., and Birben, E., The role of CD14 gene promoter polymorphism in tuberculosis susceptibility, J. Microbiol. Immunol. Infect., 2013, vol. 46, no. 3, pp. 158–163.

    Article  CAS  PubMed  Google Scholar 

  44. Rajasuriar, R., Kong, Y.Y., Nadarajah, R., Abdullah, N.K., Spelman, T., Yuhana, M.Y., Ponampalavanar, S., Kamarulzaman, A., and Lewin, S.R., The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIVinfected individuals, J. Transl. Med., 2015, vol. 13, doi 10.1186/s12967-015-0391-6

    Google Scholar 

  45. Zhao, L., and Bracken, M., Association of CD14-260 (-159) C>T and asthma: a systematic review and metaanalysis, Med. Genet., 2011, no. 11, pp. 122–129.

    Google Scholar 

  46. Perin, P., Berce, V., and Potocnik, U., CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma, Respir. Med., 2011, vol. 105, doi 10.1016/S0954-6111(11)70012-9

    Google Scholar 

  47. Bucková, D., Hollá, L., Znojil, V., and Vasku, A., Polymorphisms of the CD14 gene and atopic phenotypes in Czech patients with IgE-mediated allergy, J. Hum. Genet., 2006, vol. 51, no. 11, pp. 977–983.

    Article  PubMed  Google Scholar 

  48. Wang, J., Guo, X., Yu, S., Song, J., Zhang, J., Cao, Z., Wang, J., Liu, M., and Dong, W, Association between CD14 gene polymorphisms and cancer risk: a metaanalysis, PLoS One, 2014, vol. 9, no. 6, p. e100122.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Helicobacter Pylori Research from Bench to Bedside. Backert, S. and Yamaoka, Y., Eds., Springer, 2016, 640 p.

  50. Li, Y., Wang, X., Zhou, C., Xu, J., and Qian, Y., CD14 gene–159C/T polymorphism and coronary artery disease: a meta-analysis involving 4467, Int. J. Clin. Exp. Med., 2015, vol. 8, no. 8, pp. 12149–12160.

    PubMed  PubMed Central  Google Scholar 

  51. Zhang, Y., Tian, C., Zhang, J. et al., The-159C/T polymorphism in the CD14 gene and the risk of asthma: a meta-analysis, Immunogenetics, 2011, vol. 63, no. 1, pp. 23–32.

    Article  CAS  PubMed  Google Scholar 

  52. Govorin, A.V., Clinical and Pathogenetic Patterns of Influenza the H1N1, Novosibirsk: Nauka, 2015, 256 p.

    Google Scholar 

  53. Rakitina, N.S., Immunological predictors of infectious complications in renal transplant recipients, Cand. Sci. (Med.) Dissertation. 14.03.09, 2015.

    Google Scholar 

  54. Abdolvahabi, R., Sarrafnejad, A., Nafar, M., and Amirzargar, F., Single nucleotide polymorphisms of innate immune receptors in patients with renal rejection, Mol. Biochem. Diagn., 2016, vol. 2, no. 1, pp. 43–50.

    Google Scholar 

  55. Areeshi, M.Y., Mandal, R.K., Panda, A.K, Bisht, S.C., and Haque, S., CD14-159C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis, PLoS One, 2013, vol. 8, no. 5, p. e64747.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Bardiaa, A., Rout, S., Vishwakarma, S.K., Reddy, C.L., Ahmed, S.I., Nallari, and Khan, A.A., Effect of genetic polymorphisms in CD14 and TLR4 on cardiomyopathy, Immunother. Open Acc., 2016, vol. 2, p. 110. doi 10.4172/2471-9552.1000110

    Article  Google Scholar 

  57. Bondarenko, K.R., Mavsiyutov, A.R., and Ozoliniya, L.A., The indicators of anti-endotoxin immunity under preeclampsia, Klinicheskaya laboratornaya dia-gnostika, 2014, no. 7, pp. 55–57.

    Google Scholar 

  58. Sidorenko, G.I., Biomedical research in environmental health and prospects of their development in the Twelfth Five-Year Plan, Hihiena i sanitariya (Hygiene and sanitation), 1986, no. 12, pp. 4–7.

    Google Scholar 

  59. Moghadampour, M., Eskandari-Nasab, E., and Shabani, F., Relationship between CD14-159/CT gene polymorphism and acute brucellosis risk, Asian Pac. J. Trop. Med., 2016, vol. 9, no. 3, pp. 247–251.

    Article  CAS  PubMed  Google Scholar 

  60. Maniatis, T., Fritsch, E. F., and Sambrook, J., Molecular Cloning, Cold Spring Harbor, New York: Cold Spring Harbor Lab. Press, 1982.

    Google Scholar 

  61. Kaminski, L.S., Statistical Analysis of Laboratory and Clinical Data, Leningrad, 1964, 250 p.

    Google Scholar 

  62. Borovikov, V., Statistica: the Art of Data Analysis on the Computer, St. Petersburg: Piter, 2001, 656 p.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Hereditary Pathology, National Academy of Medical Sciences of Ukraine, Lviv, Ukraine

    O. V. Kens, O. Z. Gnateyko, N. S. Lukyanenko & N. V. Vishtak

  2. Okhmatdyt Regional Children’s Clinical Hospital, Lviv, Ukraine

    V. I. Bergtravm

Authors
  1. O. V. Kens
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. Z. Gnateyko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. S. Lukyanenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. V. Vishtak
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. I. Bergtravm
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to O. V. Kens.

Additional information

Original Ukrainian Text © O.V. Kens, O.Z. Gnateyko, N.S. Lukyanenko, N.V. Vishtak, V.I. Bergtravm, 2017, published in Tsitologiya i Genetika, 2017, Vol. 51, No. 5, pp. 55–61.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kens, O.V., Gnateyko, O.Z., Lukyanenko, N.S. et al. Analysis of molecular genetic study on the polymorphic C-159T locus of the CD14 gene in children with increased risk of recurrent episodes of acute obstructive bronchitis. Cytol. Genet. 51, 365–370 (2017). https://doi.org/10.3103/S0095452717050036

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.3103/S0095452717050036

Keywords

Search

Navigation