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Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion

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Abstract

The molecular-genetic testing of the polymorphic rs2981579 (C>T) locus of the FGFR2 gene as the marker of increased predisposition to the development of mesial occlusion was carried out in 110 patients with mesial occlusion and 103 general-population control subjects from Ukraine. It was shown that polymorphism rs2981579 in gene FGFR2 is associated with mesial occlusion (OR = 1.67, 95% CI = 1.14–2.45, p = 0.009). Compared to CC carriers, TT+CT carriers had a 3.21-fold higher risk of mesial occlusion (95% CI = 1.57–6.57, p = 0.001). We found the protective effect of the homozygous allele C on mesial occlusion development (OR = 0.31, p = 0.001). This is the first published data on FGFR2 polymorphisms rs2981579 (C>T) in patients with mesial occlusion.

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Authors and Affiliations

  1. Bogomolets National Medical University, Kyiv, 01601, Ukraine

    K. V. Storozhenko

  2. National Pirogov Memorial Medical University, Vinnytsya, 21000, Ukraine

    V. M. Shkarupa

Authors
  1. K. V. Storozhenko
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  2. V. M. Shkarupa
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Correspondence to V. M. Shkarupa.

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Original Ukrainian Text © K.V. Storozhenko, V.M. Shkarupa, 2017, published in Tsitologiya i Genetika, 2017, Vol. 51, No. 5, pp. 50–54.

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Storozhenko, K.V., Shkarupa, V.M. Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion. Cytol. Genet. 51, 361–364 (2017). https://doi.org/10.3103/S0095452717050103

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  • DOI: https://doi.org/10.3103/S0095452717050103

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