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Antineoplastic Activity In Vitro of 2-amino-5-benzylthiasol Derivative in the Complex with Nanoscale Polymeric Carriers

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Abstract

The main problems of contemporary chemotherapy are the insufficient efficacy of antitumor drugs and low selectivity of their action, development of multidrug resistance, and poor water solubility of antitumor drugs. One of the ways to improve the targeted delivery of drugs and increase their solubility is the use of polymeric nanoscale carriers. The newly synthesized thiazole derivative (N-(5-benzyl-1,3-thiazol-2-yl)-3,5-dimethyl-1-benzofuran-2-carboxamide, BF1) is cytotoxic in its activity towards some tumor cell lines. The aim of this study was to investigate the action of BF1 conjugated with novel polymeric carriers based on polyethylene glycol (PEG). The synthesized complexes exhibited a higher level of cytotoxicity towards specific tumor cell lines than the pure (unconjugated) thiazole derivative or/and doxorubicin (positive control). Complexes 4, 14 and 8, 18 were the most toxic to the human hepatocarcinoma HepG2 and the rat glioma C6 cell lines. Complex 6 exhibited a high level of toxicity towards human glioblastoma T98G and human promyelocytic leukemia HL-60 cell lines. Thus, complexes 4 and 14 based on poly(VEP-co-GMA)-graft-mPEG, complex 6 based on poly(PEGMA), and complexes 8 and 18 based on poly(PEGMA-co-DMM) selectively increase the toxic action of thiazole derivative BF1 towards tumor cells.

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Funding

The study was supported under the state budgeted program no. 0119U002201, Ministry of Education and Science of Ukraine.

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Authors and Affiliations

  1. Ivan Franko Lviv National University, Biological Faculty, 79005, Lviv, Ukraine

    N. S. Finiuk, M. V. Popovych, Ya. R. Shalai, S. M. Mandzynets’, V. P. Hreniuh & A. M. Babsky

  2. Institute of Cell Biology, National Academy of Sciences of Ukraine, 79005, Lviv, Ukraine

    N. S. Finiuk & R. S. Stoika

  3. Ivan Franko Lviv National University, Chemical Faculty, 79005, Lviv, Ukraine

    Yu. V. Ostapiuk & M. D. Obushak

  4. Lviv Polytechnic National University, Institute of Chemistry and Chemical Technologies, 79013, Lviv, Ukraine

    N. E. Mitina & O. S. Zaichenko

Authors
  1. N. S. Finiuk
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  2. M. V. Popovych
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  3. Ya. R. Shalai
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  4. S. M. Mandzynets’
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  5. V. P. Hreniuh
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  6. Yu. V. Ostapiuk
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  7. M. D. Obushak
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  8. N. E. Mitina
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  9. O. S. Zaichenko
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  10. R. S. Stoika
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  11. A. M. Babsky
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Corresponding authors

Correspondence to N. S. Finiuk, M. V. Popovych, Ya. R. Shalai, S. M. Mandzynets’, V. P. Hreniuh, Yu. V. Ostapiuk, M. D. Obushak, N. E. Mitina, O. S. Zaichenko, R. S. Stoika or A. M. Babsky.

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The authors declare that they have no conflict of interests.

This paper does not contain any investigations with the participation of people and animals as the objects of studies.

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Translated by N. Tarasyuk

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Finiuk, N.S., Popovych, M.V., Shalai, Y.R. et al. Antineoplastic Activity In Vitro of 2-amino-5-benzylthiasol Derivative in the Complex with Nanoscale Polymeric Carriers. Cytol. Genet. 55, 19–27 (2021). https://doi.org/10.3103/S0095452721010084

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