- © 2017 Marshfield Clinic
Recurrent Thrombosis in Patients with Antiphospholipid Syndrome Receiving Newer Oral Anticoagulants: A Case Report and Review of Literature
- Akanksha Joshi, MD*⇑,
- Jason Hong, MD† and
- Chokkalingam Siva, MD, MS, FACP‡
- *Division of Rheumatology, Department of Internal Medicine, University of Missouri, Columbia, Missouri, USA
- †Department of Medicine, University of Missouri, Columbia, Missouri, USA
- ‡Division of Rheumatology, Department of Internal Medicine, University of Missouri, Columbia, Missouri, USA
- Corresponding Author:
Akanksha Joshi, MD, Division of Rheumatology, University of Missouri School of Medicine, 5 Hospital Drive, Columbia, MO 65212, Tel: (573) 882-8095, Fax: (573) 882-1380, Email: akankshadr{at}gmail.com
Abstract
We present the case of a patient with primary APS who had a recurrence of thrombotic event while on treatment with rivaroxaban and had to be restarted on warfarin. The current literature on recurrence of thrombotic events in patients with antiphospholipid syndrome (APS) treated with newer oral anticoagulants (NOAC) is also reviewed. Relevant case reports and case series were identified by searching the Medline database using the key words antiphospholipid syndrome, anticoagulants and names of the NOACs, and data on individual patients was abstracted. We identified several reports on the failure of newer anticoagulants in APS, as well as cases and clinical trial results reporting efficacy. We conclude that treatment strategies for APS should be tailored cautiously when using NOACs.
