G-CSF Mobilised Progenitor Cells in Autologous Transplantation <I>IN VITRO</I> and <I>IN VIVO</I> Aspects

C. G. BEGLEY; E. DELUCA; P. A. ROWLINGS; J. SZER; D. WATSON; C. JUTTNER; G. MORSTYN; R. M. FOX; W. SHERID

doi:10.3177/jnsv.38.Special_368

G-CSF Mobilised Progenitor Cells in Autologous Transplantation

IN VITRO and IN VIVO Aspects

C. G. BEGLEY, E. DELUCA, P. A. ROWLINGS, J. SZER, D. WATSON, C. JUTTNER, G. MORSTYN, R. M. FOX, W. SHERID

Author information

C. G. BEGLEY
The Royal Melbourne Hospital, Post Office
The Walter and Eliza Hall Institute of Medical Research, Post Office
E. DELUCA
The Royal Melbourne Hospital, Post Office
The Walter and Eliza Hall Institute of Medical Research, Post Office
P. A. ROWLINGS
The Royal Adelaide Hospital, Adelaide
J. SZER
The Alfred Hospital, Commercial Road, Prahran
D. WATSON
The Royal Melbourne Hospital, Post Office
C. JUTTNER
The Royal Adelaide Hospital, Adelaide
G. MORSTYN
The Royal Melbourne Hospital, Post Office
The Ludwig Institute for Cancer Research, Parkville
R. M. FOX
The Royal Melbourne Hospital, Post Office
W. SHERID
The Royal Melbourne Hospital, Post Office

JOURNAL FREE ACCESS

1992 Volume 38 Issue Special Pages 368-371

DOI https://doi.org/10.3177/jnsv.38.Special_368

Details

Abstract

G-CSF administration leads to significant elevation in the levels of circulating progenitor cells. Infusion of these cells after high-dose chemotherapy is associated with accelerated platelet engraftment that has a considerable impact in shortening thrombocytopenia and reducing need for platelet transfusions.

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