A Review of Anti-hyperglycemic Effects of Curry Leaf Tree (Murraya koenigii)
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Submitted
26 February 2022
Published
31 May 2022
Keywords:
-
Curry leaf tree, Traditional Medicine, Review, Murraya koenigii, Diabetes
Abstract
Diabetes mellitus is becoming a metabolic disease that is defined by the level of hyperglycemia. Nowadays, it has a serious threat to public healthiness in throughout the world. Constituents and extracts isolated from diverse natural resources, mainly plants, have constantly been a rich store for controlling and treating diabetes problems. Numerous researches are ongoing to identify the suitable traditional medical drugs, medicinal herbs, and resources for managing this condition. Murraya koenigii Spreng (family Rutaceae) is commonly known as a ‘curry leaf tree’ locally. It is widely scattered in India and Sri Lanka, and leaves are commonly used for cooking. And also mainly used for various health conditions such as diabetes, anemia, diarrhea, and others. The present review aimed to critically review the anti-hyperglycemic effect of the M. koenigii based on the review, in vitro, in vivo, and clinical studies. Based on this review, the M. koenigii possess flavonoids, phenols, saponins, alkaloids, tannins, and cardiac glycosides. It has shown a potential anti-hyperglycemic effect on induced diabetic rats. This review reported the potential of M. koenigii and its extract to be a high-value dietary product in terms of its anti-hyperglycemic effects and industrial profits. Therefore, the present review supports the researchers and readers/users to realize the importance of using M. koenigii in managing diabetes mellitus. Further, this review provides a valuable document for future scientific-related clinical trials in diabetic patients.
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References
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2. Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 2011;34(6):1249-57. doi:10.2337/dc11-0442
3. Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Sci Rep. 2020;10(1):14790. doi:10.1038/s41598-020-71908-9
4. Tran N, Pham B, Le L. Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery. Biology. 2020;9(9):252. doi:10.3390/biology9090252
5. Jacob B, Narendhirakannan RT. Role of medicinal plants in the management of diabetes mellitus: a review. 3 Biotech. 2019;9(1):4. doi:10.1007/s13205-018-1528-0
6. Kesari AN, Kesari S, Singh SK, Gupta RK, Watal G. Studies on the glycemic and lipidemic effect of Murraya koenigii in experimental animals. J Ethnopharmacol. 2007;112(2):305-11. doi:10.1016/j.jep.2007.03.023
7. Jain V, Momin M, Laddha K. Murraya Koenigii: An Updated Review. Int J Ayurvedic Herb Med. 2012;2(4):607-27.
8. Muthulinggam N, Partiban S. Murraya koenigii (curry leave)- A review on its potential. Int J PharmTech Res. 2015;7(4):566-72.
9. Saini SC, Reddy GBS. A Review on Curry Leaves (Murraya koenigii): Versatile Multi-Potential Medicinal Plant. Am J Phyto Clin Ther. 2015;3(4):363-8.
10. Saini SC, Reddy GBS. Murraya koenigii. IOSR J Pharm Biol Sci. 2013;7(6):15-8.
11. Muthumani P, Venkatraman S, Ramseshu K, Meera R, Devi P, Kameswari B, et al. Pharmacological studies of anticancer, anti-inflammatory activities of Murraya koenigii (Linn) Spreng in experimental animals. J Pharm Sci Res. 2009;1(3):137-41.
12. Debosree G, Firdaus SB, Mitra E, Dey M, Bandyopadhyay D. Protective effect of aqueous leaf extract of murraya koenigii against lead induced oxidative stress in rat liver, heart and kidney: a dose response study. Asian J Pharm Clin Res. 2012;5(Suppl 4):54–9.
13. Mittal J, Jain M, Gilhotra R, Singh RP. Curry leaf (Murraya koenigii): a spice with medicinal property. MOJ Biol Med. 2017;2(3):236-56. doi:10.15406/mojbm.2017.02.00050
14. Ito C, Itoigawa M, Nakao K, Murata T, Tsuboi M, Kaneda N, et al. Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii. Phytomedicine. 2006;13(5):359–65. doi:10.1016/j.phymed.2005.03.010
15. Iyer D, Uma Devi P. Phyto-pharmacology of Murraya koenigii (L.). Pharmacogn Rev. 2008;2(3):180-4.
16. Kureel SP, Kapil RS, Popli SP. Two novel alkaloids from Murraya koenigii spreng: mahanimbicine and bicyclomahanimbicine. Chem Ind. 1970;29:958.
17. Adebajo CA, Olugbade TA, Elujoba AA, Aladesanmi AJ, Reisch J. 2”, 3” Epoxyindicolactone from Murraya koenigii. Niger J Nat Prod Med. 1997; 1(1):21–4. doi:10.4314/njnpm.v1i1.11794
18. Handral HK, Jha PK, Shruthi SD. Pharmacognostic and phytochemical studies on the leaves of Murraya koenigii L Spreng. Pharmacophore. 2010;1(3):231-8.
19. Ajay S, Rahul S, Sumit G, Paras M, Mishra A, Gaurav A. Comprehensive review: Murraya koenigii Linn. Asian J Pharm Life Sci. 2011; 1(4):417-25.
20. Batool S, Khera RA, Hanif MA, Ayub MA, Memon S. Medicinal Plants of South Asia. Amsterdam: Elsevier; 2020. Chapter 14, Curry Leaf; p.179-90. doi:10.1016/B978-0-08-102659-5.00014-8
21. Abeysinghe DT, Alwis DDDH, Kumara KAH, Chandrika UG. Nutritive Importance and Therapeutics Uses of Three Different Varieties (Murraya koenigii, Micromelum minutum, and Clausena indica) of Curry Leaves: An Updated Review. Evid Based Complementary Altern Med. 2021;2021:5523252. doi:10.1155/2021/5523252
22. Joseph B, Jini D. Insight in to the hypoglycemic effect of Traditional Indian Herbs used in the Treatment of Diabetes. Res J Medicinal Plant. 2011;5(4):352-76. doi:10.17311/rjmp.2011.352.376
23. Matheka DM, Alkizim FO. Complementary and alternative medicine for type 2 diabetes mellitus: Role of medicinal herbs. J Diabetes Endocrinol. 2012;3(4):44-56. doi:10.5897/JDE12.008
24. Qais N, Jahan S, Shafiullah MS. A Review on Anti-diabetic Plants. Dhaka Univ J Pharm Sci. 2018;17(1):139-52. doi:10.3329/dujps.v17i1.37130
25. Thakur G, Pal K, Mitra A, Mukherjee S, Basak A, Rousseau D. Some Common Anti-diabetic Plants of the Indian Subcontinent. Food Rev Int. 2010;26(4):364-85. doi:10.1080/87559129.2010.496024
26. Handral HK, Pandith A, Shruthi SD. A Review on Murraya Koenigii: Multi potential Medicinal Plant. Asian J Pharm Clin Res. 2012;5(4):5-14.
27. Nouman SM, Shehzad A, Butt MS, Khan MI, Tanveer M. Phytochemical profiling of curry (Murraya koenijii) leaves and its health benefits. Pak J Food Sci. 2015;25(4):204-15.
28. Jacob B, Narendhirakannan RT. Role of medicinal plants in the management of diabetes mellitus: a review. 3 Biotech. 2019; 9:4. doi:10.1007/s13205-018-1528-0
29. Goel A, Sharma A, Kulshrestha S. A Phytopharmacological Review on Murraya koenigii: An Important Medicinal Plant. Int J Pharm Sci Rev Res. 2020;62(2):113-9.
30. Singh S. Omreb PK, Mohanc SM. Curry Leaves (Murraya koenigii Linn. Sprengal)- A Mircale Plant. Indian J Sci Res. 2014;4(1):46-52.
31. Singh J, Singh J, Kaur S. Herbal Interventions in Managing Diabetes Mellitus: A Review. Plant Arch. 2020;20(2):2781-91.
32. Singh AG. Murraya Koenigii (L.) Spreng-Curry Leaves/Mitho Nim - A Miracle Plant. Butwal Campus J. 2020; 3(1):125-30. doi:10.3126/bcj.v3i1.36515
33. Balakrishnan R, Vijayraja D, Jo SH, Ganesan P, Su-Kim I, Choi DK. Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds. Antioxidants. 2020;9(2):101. doi:10.3390/antiox9020101
34. Katoch A, Batta B, Kumar A, Sharma PC. Screening of Murraya koenigii (Curry) and Camellia sinensis (Tea) leaves for antimicrobial activity against strains of Staphylococcus aureus, Pseudomonas aeruginosa and Candida species and their Phytochemical Analysis. Int J Pharm Sci Res. 2013;4(2);862-8. doi:10.13040/IJPSR.0975%2D8232.4(2).862%2D68
35. James SA, Omwirhiren R Efe M, Joshua IA, Dutse I. Anti-diabetic Properties and Phytochemical Studies of Ethanolic Leaf Extracts of Murraya Koenigii and Telfairia Occidentalis on Alloxan-Induced Diabetic Albino Rats. Adv Life Sci Technol. 2016;49:57-66.
36. Igara CE, Omoboyowa DA, Ahuchaogu AA, Orji NU, Ndukwe MK. Phytochemical and nutritional profile of Murraya Koenigii (Linn) Spreng leaf. J Pharmacogn Phytochem. 2016;5(5):7-9.
37. Arsha T, Rani MAS. Preliminary Phytochemical and Anatomical Studies on Bark and Leaves of Murraya koenigii (L.) Spreng.; (Family-Rutaceae) and Pimenta dioica (L.) Merr.; (Family-Myrtaceae). Int J Res Appl Sci Eng Tech. 2019;7(3):656-61.
38. Pande M, Ingale S, Gupta S. The Pharmacognostic and phytochemical studies on the leaves of Murraya koenigii (L) Spreng. Indian J Sci Technol. 2009;2(3):53-4. doi:10.17485/IJST/2009/V2I3/29415
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Sanmugarajah V, Rajkumar G. A Review of Anti-hyperglycemic Effects of Curry Leaf Tree (Murraya koenigii). Borneo J Pharm [Internet]. 2022May31 [cited 2024Apr.20];5(2):104-1. Available from: https://journal.umpr.ac.id/index.php/bjop/article/view/3300
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