Hepatoprotective potential and chemical characterization of Artocarpus lakoocha fruit extract

Authors

  • Mohammad Saleem Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad http://orcid.org/0000-0001-5064-1584
  • Ammara Asif Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad
  • Muhammad Furqan Akhtar Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad http://orcid.org/0000-0002-2407-1503
  • Ammara Saleem Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad

DOI:

https://doi.org/10.3329/bjp.v13i1.34117

Keywords:

Artocarpus lakoocha, Hepatoprotective

Abstract

Artocarpus lakoocha fruits are widely consumed as food. The study was aimed at evaluating its hepatoprotective activity and chemical constituents. The extract was analysed by HPLC for the presence of flavonoids and phenolic compounds. Hepatoprotective potential was determined in mice following 8 days of extract or silymarin (standard therapy) administration. Hepatotoxicity was induced by administration of paracetamol (500 mg/kg). The blood and liver of treated and untreated mice were collected 24 hours post-paracetamol intoxication. HPLC analysis confirmed the presence of chromatotropic acid, quercetin, gallic acid, vanillic acid, cinnamic acid, ferulic acid and kaempferol. Acute toxicity study showed no observed effect at more than 2,000 mg/kg. The fruit extract prevented the rise in liver function tests and paracetamol related histopathological alterations. The hepatoprotective activity of extract was dose-dependent. This study confirms the preventive effect of methanolic extract of monkey jack fruits against paracetamol-induced liver toxicity.

Video Clip of Methodology:

7 min 25 sec:   Click to watch

Downloads

Download data is not yet available.
Abstract
3154
Download
1318 Read
1131

Downloads

Additional Files

Published

2018-03-20

How to Cite

Saleem, M., A. Asif, M. F. Akhtar, and A. Saleem. “Hepatoprotective Potential and Chemical Characterization of Artocarpus Lakoocha Fruit Extract”. Bangladesh Journal of Pharmacology, vol. 13, no. 1, Mar. 2018, pp. 90-97, Mar 20, 2018, doi:10.3329/bjp.v13i1.34117.

Issue

Vol. 13 No. 1 (2018)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).