Formulation and evaluation of enteric coated tablet of Ilaprazole

Authors

  • Surya Bhan Singh Rathore Bhupal Nobles? College of Pharmacy Udaipur-313002, Rajasthan
  • Anshu Sharma Bhupal Nobles? College of Pharmacy Udaipur-313002, Rajasthan
  • Ayush Garg Bhupal Nobles? College of Pharmacy Udaipur-313002, Rajasthan
  • Dharmendra Singh Sisodiya Bhupal Nobles? College of Pharmacy Udaipur-313002, Rajasthan

DOI:

https://doi.org/10.3329/icpj.v2i7.15156

Keywords:

Ilaprazole, HPMC P 50, Eudragit L 100, delayed release, enteric coated

Abstract

The present study was an attempt to formulate and evaluate enteric coated tablets for Ilaprazole to reduce the gastrointestinal tract side effects. Four formulations of core tablets were prepared and one who shows rapid disintegration (near around three minutes) was selected for enteric coating. Ilaprazole which have an irritant effect on the stomach can be coated with a substance that will only dissolve in the small intestine. Enteric coat was optimized using two different polymers such as HPMCP 50 and Eudragit L 100 in different concentrations. The prepared tablets were evaluated in terms of their pre-compression parameters, physical characteristics and in-vitro release study. 2.5% seal coating on core tablets was optimized and 9% enteric coating on seal coated tablets was performed using HPMC P 50 (60%), triethyl citrate (10%) and IPA:DCM (60:40) which gives the highest dissolution release profile and f2 value.

DOI: http://dx.doi.org/10.3329/icpj.v2i7.15156

International Current Pharmaceutical Journal, June 2013, 2(7): 126-130

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Published

2013-06-01

How to Cite

Rathore, S. B. S., Sharma, A., Garg, A., & Sisodiya, D. S. (2013). Formulation and evaluation of enteric coated tablet of Ilaprazole. International Current Pharmaceutical Journal, 2(7), 126–130. https://doi.org/10.3329/icpj.v2i7.15156

Issue

Vol. 2 No. 7 (2013)

Section

Original Articles

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