Atherosclerosis in rats after immunization with human native low-density lipoproteins
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1
Udmurt State University, Russia
The principal unsolved question of atherogenesis is why and how lipoprotein metabolism becomes unbalanced. The purpose of this research is to test the hypothesis that autoimmune reaction to native LDL (nLDL) is the cause of dyslipoproteinemia and atherogenesis in the vascular wall. In order to check our hypothesis we made an attempt to induce autoimmune reaction to nLDL in rats. In cases of autoimmune reaction we expected dyslipoproteinemia and development of atherosclerosis features. A single immunization of rats with human nLDL leads to self-maintained, self-reinforced anti-nLDL autoantibodies production in most of rats. Anti-nLDL autoantibodies response was accompanied by dyslipoproteinemia and caused increase of epicardial and perivascular adipose tissue volume, decrease of cholesterol level in adrenal glands, accumulation of inflammatory cells in aorta wall, together with intima destruction and media disorder. The achieved results are evidence in a favor of the hypothesis that autoimmunity to native LDL is the cause of atherosclerosis development.
Acknowledgements
The study was supported by the Ministry of Education and Science of Russian Federation, projects 14.B37.21.0211; 14.B37.21.0564.
Keywords:
Atherosclerosis,
rat model,
native LDL,
epicardial adipose tissue,
Autoantibodies
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Menshikov
I,
Fomina
K and
Beduleva
L
(2013). Atherosclerosis in rats after immunization with human native low-density lipoproteins.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00389
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Received:
23 Mar 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Prof. Igor Menshikov, Udmurt State University, Izhevsk, Russia, miv140560@yandex.ru