Roadmap on Universal Photonic Biosensors for Real-Time Detection of Emerging Pathogens
Abstract
:1. Introduction
2. Affinity-Type Biosensors with Optical Signal Amplification
3. Label-Free Spectroscopic Sensors with Digital and Optical Amplification
4. Cleavage-Based Sensing
Further Avenues for Cleavage-Based Photonic Sensors
5. Conclusions and Outlook
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
Abbreviations
ATR | Attenuated Total Reflection |
Cas | CRISPR-associated |
CRISPR–Cas | Clustered Regularly Interspaced Short Palindromic Repeats-associated complexes |
crRNA | CRISPR RNA |
DNase | Deoxyribonuclease |
DLB | Dementia with Lewy bodies |
fM | Femtomolar |
FQ | Fluorophore-Quencher |
FTIR | Fourier-Transform Infrared |
FWHM | Full Width at Half Maximum |
GDM | Gestational Diabetes Mellitus |
HCV | Hepatitis C Virus |
HIV | Human Immunodeficiency Virus |
IR | Infrared |
LAMP | Loop-mediated AMPlification |
LOD | Limit of Detection |
LSPR | Localized Surface Plasmon Resonance |
MIR | Mid-Infrared |
NIR | Near-Infrared |
POC | Point-of-care |
PhC | Photonic crystal |
RI | Refractive Index |
RNA | Ribonucleic Acid |
RT-PCR | Reverse Transcription Polymerase Chain Reaction |
SARS-CoV-2 | Severe Acute Respiratory Syndrome CoronaVirus 2 |
SERS | Surface-Enhanced Raman Spectroscopy |
SHERLOCK | Specific High-Sensitivity Enzymatic Reporter UnLOCKing |
SNR | Signal-to-Noise Ratio |
SPR | Surface Plasmon Resonance |
TERS | Tip-Enhanced Raman Spectroscopy |
Q | Quality |
WGM | Whispering Gallery Mode |
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Pathogen/Disease | Sample Type | Spectroscopic Technique | Sensitivity | Specificity | Accuracy | Population (Prevalence) | Ref. |
---|---|---|---|---|---|---|---|
Alzheimer’s Disease | Blood (plasma) | NIR | 87.5% | 96.1% | 92.8% | 277 (39%) | [127] |
Alzheimer’s Disease-DLB | Blood (plasma) | Raman | 81–90% | 77–93% | - | 56 (-) | [128] |
Cancer (various) | Blood (whole) | MIR | - | - | 90% | 43 (40%) | [118] |
Cancer (brain) | Blood (serum) | MIR | 95.5% | 94.9% | - | 183 (52%) | [129] |
Cancer (breast) | Blood (serum) | MIR | 92.3% | 87.1% | 89.3% | 146 (45%) | [130] |
Cancer (breast) | Blood (serum) | Raman | 97% | 78% | - | 23 (48%) | [131] |
Cancer (breast) | Tissue | Raman | 94% | 96% | - | 130 (-) | [132] |
Cancer (breast) | Blood (serum) | MIR | >85% | - | 223 (49%) | [133] | |
Cancer (cervical) | Blood (serum) | Raman | 100% | 97.1% | - | 42 (53%) | [134] |
Cancer (colorectal) | Tissue | MIR | 81.4% | 92.7% | - | 88 (54%) | [134] |
Cancer (endometrial) | Blood (serum) | MIR | - | - | 82.0% | 60 (50%) | [135] |
Cancer (Glioma) | Blood (serum) | MIR | 98.5% | 95.1% | 96.8% | 265 (33%) | [136] |
Cancer (Glioma) | Blood (serum) | MIR | 87.5% | 100% | - | 74 (66%) | [137] |
Cancer (lung) | Tissue | MIR | 78–99% | 65–99% | - | 38 (-) | [138] |
Cancer (lung) | Sputum | MIR | 100% | 92.0 | - | 50 (50%) | [139] |
Cancer (oral) | Tissue | Raman | 90.9% | 83.3% | 87.5% | 80 (55%) | [140] |
Cancer (ovarian) | Blood (serum) | MIR | 76% | 98% | 94% | 378 (19%) | [141] |
Cancer (ovarian) | Blood (serum) | MIR | - | - | 95% | 60 (50.5%) | [135] |
Cancer (ovarian) | Blood (serum) | Raman | 94 | 96 | 95% | 55 (49%) | [142] |
Cancer (ovarian) | Blood (plasma) | MIR | 71% | 84% | 81% | 378 (19%) | [141] |
Cancer (prostate) | Tissue | MIR | 92.3% | 99.4% | - | 40 (-) | [143] |
Dengue, Zika, Chikungunya | Blood (whole) | MIR | 98% | 0.98% | 0.98% | 130 (65%) | [117] |
Dengue | Blood (serum) | MIR | 87.5% | 95.0% | 90.5% | 77 (74%) | [144] |
Dengue | Blood (plasma) | Raman | 97.38–97.95% | 86.18–95.40% | - | 34 (50%) | [145] |
Dengue-Malaria | Blood (serum) | Raman | 83.3% | 100% | - | 44 (-) | [145] |
Hepatitis (B-C) | Blood (serum) | MIR | 77.3–79.6% | 85.1–76.2% | - | 497 (62%) | [115] |
Hepatitis (B) | Blood (serum) | MIR | 84.3% | 91.3% | - | 333 (44%) | [115] |
Hepatitis (B) | Blood (serum) | Raman | 100% | 88.0% | 93.1 | 1000 (50%) | [146] |
Hepatitis (B) | Blood (plasma) | Raman | 98.9% | 98.8% | 98.8 | 34 (29%) | [147] |
Hepatitis (C) | Blood (serum) | MIR | 77.2% | 92.3% | - | 345 (48%) | [115] |
Hepatitis (C) | Blood (serum) | Raman | 92% | 88% | - | 29 (41%) | [148] |
Hepatic fibrosis | Blood (serum) | MIR | 95.2% | 100% | 97.5% | 23 (52%) | [149] |
HIV-HCV | Blood (plasma) | MIR | - | 100% | 93.7% | 72 (73%) | [150] |
HIV | Blood (serum) | MIR | 83% | 92% | - | 120 (33%) | [151] |
GDM | Blood (serum) | MIR | 100% | 100% | 100% | 100 (50%) | [152] |
Influenza | Nasal aspirate | NIR | 97% | 100% | - | 67 (49%) | [153] |
Kidney disease | Blood (serum) | NIR | 90–100% | 100% | - | 64 (25%) | [154] |
SARS-CoV-2 | Pharyngeal Swab | MIR | 95% | 89% | - | 181 (39%) | [155] |
SARS-CoV-2 | Saliva | Raman | 83.7–97.5% | 92.2–98.5% | - | 101 (-) | [156] |
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Blevins, M.G.; Fernandez-Galiana, A.; Hooper, M.J.; Boriskina, S.V. Roadmap on Universal Photonic Biosensors for Real-Time Detection of Emerging Pathogens. Photonics 2021, 8, 342. https://doi.org/10.3390/photonics8080342
Blevins MG, Fernandez-Galiana A, Hooper MJ, Boriskina SV. Roadmap on Universal Photonic Biosensors for Real-Time Detection of Emerging Pathogens. Photonics. 2021; 8(8):342. https://doi.org/10.3390/photonics8080342
Chicago/Turabian StyleBlevins, Morgan G., Alvaro Fernandez-Galiana, Milo J. Hooper, and Svetlana V. Boriskina. 2021. "Roadmap on Universal Photonic Biosensors for Real-Time Detection of Emerging Pathogens" Photonics 8, no. 8: 342. https://doi.org/10.3390/photonics8080342