Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications
Abstract
:1. Introduction
2. Mouse Gpr37 Mutant Strains
3. Mouse Gpr37l1 Mutant Strains
4. Disease Modeling Applications
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Allele/Transgene Symbol (MGI ID) Type of Mutant/Transgenic Strain | Genetic Background | References |
---|---|---|
Gpr37<tm2Gtva> (MGI: 3027995) targeted constitutive KO strain obtained by crossing of Gpr37<tm1Gtva> (MGI: 3027992) targeted conditional-ready strain to Tg(CMV-cre)1Cgn (MGI: 2176180) cre recombinase-expressing strain | ES cells: 129P2/OlaHsd crossing: C57BL/6J N: 2–10 cre recomb.: BALB/c, C57BL/6 | [11,12,13,14,15,16,17] |
Gpr37<tm1.1Ryot> (MGI: 3768566) targeted constitutive KO strain obtained by in vitro cre recombinase expression in oocytes of Gpr37<tm1Ryot> (MGI: 3768565) targeted conditional-ready strain | ES cells: C57BL/6NSlc crossing: C57BL/6 | [18] |
Tg(Prp-GPR37)1Ryot (MGI: 3768632) brain-specific transgene-expressing strain | oocytes: C3H, C57BL/6 crossing: C57BL/6 | [18,19] |
Tg(PDGFB-GPR37)20Ryot (MGI: 3768633) midbrain, striatum-specific transgene-expressing strain | oocytes: C57BL/6 crossing: C57BL/6 | [18,19] |
Prkn<tm1Ykt> (MGI: 3698054), Tg(Prp-GPR37)1Ryot targeted constitutive KO, brain-specific transgene-expressing strain | Prkn<tm1Ykt>: ES cells: 129P2/OlaHsd crossing: C57BL/6 Tg(Prp-GPR37)1Ryot: as above | [19,20] |
Prkn<tm1Ykt>, Tg(PDGFB-GPR37)20Ryot targeted constitutive KO, midbrain/striatum-specific transgene-expressing strain | Prkn<tm1Ykt>: as above Tg(PDGFB-GPR37)20Ryot: as above | [19,20] |
Gpr37<tm1Dgen> (MGI: 3604579) targeted lacZ reporter-tagged constitutive KO strain | ES cells: 129P2/OlaHsd crossing: C57BL/6 N: 5–10 | [17,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40] |
Gpr37<em1Smoc> (MGI: 6840940) oligodendrocyte-specific conditional KO line obtained by crossing of Gpr37<em2Smoc> (MGI: 6840941) CRISPR/Cas-mediated conditional-ready strain to an Olig2-cre recombinase transgene-expressing strain (not specified) | oocytes: C57BL/6J crossing: C57BL/6J cre recomb.: not specified | [39] |
Allele/Transgene Symbol (MGI ID) Mutation Type | Genetic Background | References |
---|---|---|
Gpr37l1<tm1Mktk> (MGI: 6763374) targeted constitutive KO strain | ES cells: 129S1/Sv crossing: C57BL/6 | [43,44,45] |
Tg(Myh6-Gpr37l1)#Mktk (MGI: 6763370) cardiac tissue-specific transgene-expressing strain | oocytes: not specified crossing: not specified | [43,45] |
Gpr37l1<tm1.2Gtva> (MGI: 5439169) targeted constitutive KO strain obtained by crossing of Gpr37l1<tm1.1Gtva> (MGI: 439168) targeted conditional-ready strain to Tg(CMV-cre)1Cgn (MGI: 2176180) cre recombinase-expressing strain | ES cells: 129S6/SvEvTac crossing: C57BL/6J N: 2–10 cre recomb.: BALB/c, C57BL/6 | [8,17,46,47,48,49] |
Gpr37l1<tm1.2Gtva>, Ptch1<tm1Zim> (MGI: 1857935) double targeted constitutive KO strain | Gpr37l1<tm1.2Gtva>: as above Ptch1<tm1Zim>: ES cells: 129S2/SvPas crossing: C57BL/6 N: >10 | [48] |
Gpr37l1<tm1Lex> (MGI: 3528734) targeted lacZ reporter-tagged constitutive KO strain | ES cells: 129S/SvEvBrd crossing: C57BL/6 N: 2–10 | [38,40,50,51] |
Gpr37l1<tm1Lex>, Gpr37<tm1Dgen> double targeted lacZ reporter-tagged constitutive KO strain | Gpr37l1<tm1Lex>: as above Gpr37<tm1Dgen>: as above (Table 1) | [38,40,52] |
Gpr37l1<tm1b(EUCOMM)Wtsi> targeted lacZ reporter-tagged constitutive KO strain obtained by crossing of Gpr37l1<tm1a(EUCOMM)Wtsi> (MGI: 4441736) targeted lacZ reporter-tagged conditional-ready strain to Tg(CMV-cre)1Cgn cre recombinase-expressing strain | ES cells: C57BL/6N-A<tm1Brd> crossing: C57BL/6 cre recomb.: BALB/c, C57BL/6 | [45,53,54,55] |
Gpr37l1<tm1d(EUCOMM)Wtsi> (MGI: 6150820) targeted reporter-free constitutive KO strain obtained by initial crossing of Gpr37l1<tm1a(EUCOMM)Wtsi> (see above) to Tg(ACTFLPe)9205Dym (MGI:2448985) Flp recombinase-expressing strain and crossing of resulting progeny to Tg(CMV-cre)1Cgn cre recombinase-expressing strain | ES cells: C57BL/6N-A<tm1Brd> crossing: C57BL/6 Flp recomb.: SJL, C57BL/6 cre recomb.: BALB/c, C57BL/6 | [45,53,54,55] |
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Massimi, M.; Di Pietro, C.; La Sala, G.; Matteoni, R. Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. Int. J. Mol. Sci. 2022, 23, 4288. https://doi.org/10.3390/ijms23084288
Massimi M, Di Pietro C, La Sala G, Matteoni R. Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. International Journal of Molecular Sciences. 2022; 23(8):4288. https://doi.org/10.3390/ijms23084288
Chicago/Turabian StyleMassimi, Marzia, Chiara Di Pietro, Gina La Sala, and Rafaele Matteoni. 2022. "Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications" International Journal of Molecular Sciences 23, no. 8: 4288. https://doi.org/10.3390/ijms23084288