Carboxymethyl-Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles for Drug Delivery: Influence of the Coating Thickness on the Particle Properties
Abstract
:1. Introduction
2. Results and Discussion
2.1. Particle Composition
2.2. Surface Properties
2.3. Particle Size
2.4. Magnetization
2.5. Cytocompatibility
2.6. Electrostatic and Covalent Binding of Lasioglossin
2.7. Antimicrobial Activity
3. Materials and Methods
3.1. Synthesis of ION@CMD
3.2. Characterization
3.3. Cytocompatibility
3.4. Peptide Loading
3.5. Antimicrobial Behavior
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Particles | Fe3O4 (%) | dTEM (nm) | dScherrer (nm) | IEP |
---|---|---|---|---|
BIONs | 15.6 | 8.7 ± 1.6 | 8.8 ± 0.9 | 7.1 |
[email protected] | 21.0 | 11 ± 2.1 | 10 ± 0.5 | 4.6 |
[email protected] | 33.9 | 11 ± 2.8 | 8.6 ± 0.1 | 4.4 |
[email protected] | 47.5 | 8.0 ± 1.7 | 5.6 ± 0.6 | 3.9 |
ION@CMD125 | 41.6 | 7.6 ± 1.6 | 4.7 ± 0.4 | 2.4 |
ION@CMD250 | 6.3 ± 1.2 | 0.6 ± 0.3 | 1.7 |
LL Used (g L−1) | Loading 280 nm (g g−1) | Drug Loading 280 nm (%) | Drug Loading TGA (%) | Zeta Potential (mV) | dH (nm) |
---|---|---|---|---|---|
0.8 | 0.55 | 35.4 | 15.4 | −29 ± 1.0 | 96.4 ± 45.7 |
1.0 | 0.60 | 35.0 | 15.3 | 2.9 ± 1.0 | 1599 ± 401 |
1.5 | 0.94 | 43.8 | 26.9 | 2.4 ± 0.3 | 4662 ± 797 |
2.0 | 1.32 | 52.4 | 33.2 | 13 ± 0.4 | 5274 ± 11.2 |
2.5 | 1.65 | 62.3 | 49.7 | 32 ± 0.9 | 5340 ± 263 |
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Turrina, C.; Milani, D.; Klassen, A.; Rojas-González, D.M.; Cookman, J.; Opel, M.; Sartori, B.; Mela, P.; Berensmeier, S.; Schwaminger, S.P. Carboxymethyl-Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles for Drug Delivery: Influence of the Coating Thickness on the Particle Properties. Int. J. Mol. Sci. 2022, 23, 14743. https://doi.org/10.3390/ijms232314743
Turrina C, Milani D, Klassen A, Rojas-González DM, Cookman J, Opel M, Sartori B, Mela P, Berensmeier S, Schwaminger SP. Carboxymethyl-Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles for Drug Delivery: Influence of the Coating Thickness on the Particle Properties. International Journal of Molecular Sciences. 2022; 23(23):14743. https://doi.org/10.3390/ijms232314743
Chicago/Turabian StyleTurrina, Chiara, Davide Milani, Anna Klassen, Diana M. Rojas-González, Jennifer Cookman, Matthias Opel, Barbara Sartori, Petra Mela, Sonja Berensmeier, and Sebastian P. Schwaminger. 2022. "Carboxymethyl-Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles for Drug Delivery: Influence of the Coating Thickness on the Particle Properties" International Journal of Molecular Sciences 23, no. 23: 14743. https://doi.org/10.3390/ijms232314743