Etoposide hypersensitivity reactions and outcomes of desensitizations in immediate-type hypersensitivity reactions
Abstract
Aims: This study aims to define characteristics of hypersensitivity reactions with etoposide, and outcomes of desensitizations in immediate-type hypersensitivity rections
Methods: This is a retrospective observational study of patients who had hypersensitivity reactions with etoposide from January 2019 to December 2023.
Results: A total of 39 patients with lung cancer were included in the study. Ten (25.6%) patients had known other drug allergies and three (7.7%) patients had previous chemotherapeutic hypersensitivity two with paclitaxel and one with docetaxel. Most of the initial hypersensitivities were in the first or second cycle (n=29, 74.4%). Ten (25.4%) patients had hypersensitivity reactions at the first application of etoposide. Thirty (76.9%) patients had immediate-type hypersensitivity reactions. There was no significant difference in terms of patient and initial hypersensitivity characteristics between patients who had immediate or non-immediate type hypersensitivity reactions. Of the 30 patients with immediate-type hypersensitivity reactions, initial reaction was mild in 16 (53.3%) and moderate in 14 (46.7%) patients. Most common symptoms were erythema in 29 (96.7%), dyspnea in 13 (43.3%), chest tightness in 8 (26.7%), discomfortness in 7 (23.3%), and hypertension in 6 (20%). Skin tests were negative in five patients who underwent skin testing. A total of 98 desensitization courses were performed in 27 patients and 3 (11.1%) patients had breakthrough reactions.
Conclusion: Most of the hypersensitivity reactions to etoposide are immediate-type and not severe. Desensitization is an effective and safe procedure to manage these reactions. Further research is needed to elucidate the mechanisms of hypersensitivity reactions.
Ethical Statement
The authors have not declared conflict of interest regarding to this manuscript. All authors gave consent for the publication of the manuscript. This study is approved by Ankara Atatürk Sanatoryum Training and Resarch Hospital, Clinical Trials Ethics Committee. Approval number: 2012-KAEK-15/2863 (date:27.12.2023) Because the study was designed retrospectively, no written informed consent form was obtained from patients The authors have no conflicts of interest to declare. The authors declared that this study has received no financial support. All of the authors declare that they have all participated in the design, execution, and analysis of the paper, and that they have approved the final version. Our study has been presented anywhere previously All authors have read the manuscript and approved its submission and met the requirements for authorship criteria. The authors confirm the manuscript is original. We also certify that all authors have written collectively at least 90% of the manuscript. The manuscript is not under consideration by any other journal at the same time and it has not been accepted for publication elsewhere.
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References
- Pagani M, Bavbek S, Alvarez-Cuesta E, et al. Hypersensitivity reactions to chemotherapy: an EAACI position paper. Allergy. 2022;77(2):388-403.
- Henwood JM, Brogden RN. Etoposide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in combination chemotherapy of cancer. Drugs. 1990;39(3):438-490.
- Martinez N, Miyasaki A, Roh L, Koole W, Fernandez KS. A pediatric desensitization protocol for etoposide. Am J Health Syst Pharm. 2020;77(4):277-281.
- Wright TE, Shah MD, Rider NL, et al. A case series of pediatric oncology patients undergoing successful rapid etoposide desensitization. Pediatr Allergy Immunol. 2019;30(5):579-582.
- Cotteret C, Rousseau J, Zribi K, Schlatter J. Severe hypersensitivity reaction to etoposide phosphate: a case report. Clin Case Rep. 2020;8(9):1821-1823.
- Hoetelmans RM, Schornagel JH, ten Bokkel Huinink WW, Beijnen JH. Hypersensitivity reactions to etoposide. Ann Pharmacother. 1996;30(4):367-371.
- Hudson MM, Weinstein HJ, Donaldson SS, et al. Acute hypersensitivity reactions to etoposide in a VEPA regimen for Hodgkin’s disease. J Clin Oncol. 1993;11(6):1080-1084.
- Bernstein BJ, Troner MB. Successful rechallenge with etoposide phosphate after an acute hypersensitivity reaction to etoposide. Pharmacotherapy. 1999;19(8):989-991.
- Siderov J, Prasad P, De Boer R, Desai J. Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide. Br J Cancer. 2002;86(1):12-13.
- Lindsay H, Gaynon P. Anaphylactic reaction to etoposide phosphate. Pediatr Blood Cancer. 2012;59(4):765.
- Ogle KM, Kennedy BJ. Hypersensitivity reactions to etoposide. A case report and review of the literature. Am J Clin Oncol. 1988;11(6):663-665.
- Vervloet D, Durham S. Adverse reactions to drugs. BMJ. 1998;316(7143):1511-1514.
- Zweizig S, Roman LD, Muderspach LI. Death from anaphylaxis to cisplatin: a case report. Gynecol Oncol. 1994;53(1):121-122.
- Castells M, Sancho-Serra Mdel C, Simarro M. Hypersensitivity to antineoplastic agents: mechanisms and treatment with rapid desensitization. Cancer Immunol Immunother. 2012;61(9):1575-1584.
- Buhari GK, Kalkan IK, Ates H, et al. Platin desensitizations in thoracic malignancies and risk factors for breakthrough reactions. Allergol Immunopathol (Madr). 2023;51(2):130-136.
- Demoly P, Adkinson NF, Brockow K, et al. International consensus on drug allergy. Allergy. 2014;69(4):420-437.
- Brown SG. Clinical features and severity grading of anaphylaxis. J Allergy Clin Immunol. 2004;114(2):371-376.
- Castells MC, Tennant NM, Sloane DE, et al. Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. J Allergy Clin Immunol. 2008;122(3):574-580.
- Stockton WM, Nguyen T, Zhang L, Dowling TC. Etoposide and etoposide phosphate hypersensitivity in children: incidence, risk factors, and prevention strategies. J Oncol Pharm Pract. 2020;26(2):397-405.
- Turgay Yagmur I, Guzelkucuk Z, Yarali N, et al. Evaluation of hypersensitivity reactions to cancer chemotherapeutic agents in pediatric patients. Ann Allergy Asthma Immunol. 2020;124(4):350-366.
- Picard M. Management of hypersensitivity reactions to taxanes. Immunol Allergy Clin North Am. 2017;37(4):679-693.
- Friedland D, Gorman G, Treat J. Hypersensitivity reactions from taxol and etoposide. J Natl Cancer Inst. 1993;85(24):2036.
- Leguay Z, Bourneau-Martin D, Pellier I, et al. Successful treatment with etoposide base after an acute hypersensitivity reaction to etoposide phosphate. Pediatr Blood Cancer. 2016;63(3):571.
- Collier K, Schink C, Young AM, How K, Seckl M, Savage P. Successful treatment with etoposide phosphate in patients with previous etoposide hypersensitivity. J Oncol Pharm Pract. 2008;14(1):51-55.
- Sambasivan K, Mahmoud S, Kokache A, Seckl M, Savage P. Hypersensitivity reactions to etoposide phosphate. J Oncol Pharm Pract. 2014;20(2):158-160.
- Babaie D, Shamsian BS, Momtazmanesh N, et al. Rapid desensitization for hypersensitivity reactions to chemotherapeutic drugs; a case series. Iran J Pharm Res. 2019;18(2):1047-1051.
- Pantin C, Letellez J, Calzas J, Mohedano E. [Indirect identification of hypersensitivity reaction to etoposide mediated by polysorbate 80]. Farm Hosp. 2018;42(1):27-28.
- Kellie SJ, Crist WM, Pui CH, et al. Hypersensitivity reactions to epipodophyllotoxins in children with acute lymphoblastic leukemia. Cancer. 1991;67(4):1070-1075.
- Kulhas Celik I, Guvenir H, Buyuktiryaki B, Dibek Misirlioglu E, Ozyoruk D, Toyran M. Successful desensitization to etoposide in a preschool pediatric patient. J Investig Allergol Clin Immunol. 2018;28(5):363-364.
- Garcia Escallon S, Muniyappa PK, Subramanian S. Successful rapid desensitization to intravenous etoposide using a 14-step protocol. J Allergy Clin Immunol Pract. 2015;3(4):627-628.
Abstract
References
- Pagani M, Bavbek S, Alvarez-Cuesta E, et al. Hypersensitivity reactions to chemotherapy: an EAACI position paper. Allergy. 2022;77(2):388-403.
- Henwood JM, Brogden RN. Etoposide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in combination chemotherapy of cancer. Drugs. 1990;39(3):438-490.
- Martinez N, Miyasaki A, Roh L, Koole W, Fernandez KS. A pediatric desensitization protocol for etoposide. Am J Health Syst Pharm. 2020;77(4):277-281.
- Wright TE, Shah MD, Rider NL, et al. A case series of pediatric oncology patients undergoing successful rapid etoposide desensitization. Pediatr Allergy Immunol. 2019;30(5):579-582.
- Cotteret C, Rousseau J, Zribi K, Schlatter J. Severe hypersensitivity reaction to etoposide phosphate: a case report. Clin Case Rep. 2020;8(9):1821-1823.
- Hoetelmans RM, Schornagel JH, ten Bokkel Huinink WW, Beijnen JH. Hypersensitivity reactions to etoposide. Ann Pharmacother. 1996;30(4):367-371.
- Hudson MM, Weinstein HJ, Donaldson SS, et al. Acute hypersensitivity reactions to etoposide in a VEPA regimen for Hodgkin’s disease. J Clin Oncol. 1993;11(6):1080-1084.
- Bernstein BJ, Troner MB. Successful rechallenge with etoposide phosphate after an acute hypersensitivity reaction to etoposide. Pharmacotherapy. 1999;19(8):989-991.
- Siderov J, Prasad P, De Boer R, Desai J. Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide. Br J Cancer. 2002;86(1):12-13.
- Lindsay H, Gaynon P. Anaphylactic reaction to etoposide phosphate. Pediatr Blood Cancer. 2012;59(4):765.
- Ogle KM, Kennedy BJ. Hypersensitivity reactions to etoposide. A case report and review of the literature. Am J Clin Oncol. 1988;11(6):663-665.
- Vervloet D, Durham S. Adverse reactions to drugs. BMJ. 1998;316(7143):1511-1514.
- Zweizig S, Roman LD, Muderspach LI. Death from anaphylaxis to cisplatin: a case report. Gynecol Oncol. 1994;53(1):121-122.
- Castells M, Sancho-Serra Mdel C, Simarro M. Hypersensitivity to antineoplastic agents: mechanisms and treatment with rapid desensitization. Cancer Immunol Immunother. 2012;61(9):1575-1584.
- Buhari GK, Kalkan IK, Ates H, et al. Platin desensitizations in thoracic malignancies and risk factors for breakthrough reactions. Allergol Immunopathol (Madr). 2023;51(2):130-136.
- Demoly P, Adkinson NF, Brockow K, et al. International consensus on drug allergy. Allergy. 2014;69(4):420-437.
- Brown SG. Clinical features and severity grading of anaphylaxis. J Allergy Clin Immunol. 2004;114(2):371-376.
- Castells MC, Tennant NM, Sloane DE, et al. Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. J Allergy Clin Immunol. 2008;122(3):574-580.
- Stockton WM, Nguyen T, Zhang L, Dowling TC. Etoposide and etoposide phosphate hypersensitivity in children: incidence, risk factors, and prevention strategies. J Oncol Pharm Pract. 2020;26(2):397-405.
- Turgay Yagmur I, Guzelkucuk Z, Yarali N, et al. Evaluation of hypersensitivity reactions to cancer chemotherapeutic agents in pediatric patients. Ann Allergy Asthma Immunol. 2020;124(4):350-366.
- Picard M. Management of hypersensitivity reactions to taxanes. Immunol Allergy Clin North Am. 2017;37(4):679-693.
- Friedland D, Gorman G, Treat J. Hypersensitivity reactions from taxol and etoposide. J Natl Cancer Inst. 1993;85(24):2036.
- Leguay Z, Bourneau-Martin D, Pellier I, et al. Successful treatment with etoposide base after an acute hypersensitivity reaction to etoposide phosphate. Pediatr Blood Cancer. 2016;63(3):571.
- Collier K, Schink C, Young AM, How K, Seckl M, Savage P. Successful treatment with etoposide phosphate in patients with previous etoposide hypersensitivity. J Oncol Pharm Pract. 2008;14(1):51-55.
- Sambasivan K, Mahmoud S, Kokache A, Seckl M, Savage P. Hypersensitivity reactions to etoposide phosphate. J Oncol Pharm Pract. 2014;20(2):158-160.
- Babaie D, Shamsian BS, Momtazmanesh N, et al. Rapid desensitization for hypersensitivity reactions to chemotherapeutic drugs; a case series. Iran J Pharm Res. 2019;18(2):1047-1051.
- Pantin C, Letellez J, Calzas J, Mohedano E. [Indirect identification of hypersensitivity reaction to etoposide mediated by polysorbate 80]. Farm Hosp. 2018;42(1):27-28.
- Kellie SJ, Crist WM, Pui CH, et al. Hypersensitivity reactions to epipodophyllotoxins in children with acute lymphoblastic leukemia. Cancer. 1991;67(4):1070-1075.
- Kulhas Celik I, Guvenir H, Buyuktiryaki B, Dibek Misirlioglu E, Ozyoruk D, Toyran M. Successful desensitization to etoposide in a preschool pediatric patient. J Investig Allergol Clin Immunol. 2018;28(5):363-364.
- Garcia Escallon S, Muniyappa PK, Subramanian S. Successful rapid desensitization to intravenous etoposide using a 14-step protocol. J Allergy Clin Immunol Pract. 2015;3(4):627-628.
Details
| Primary Language | English |
|---|---|
| Subjects | Allergy, Respiratory Diseases |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | March 8, 2024 |
| Submission Date | February 2, 2024 |
| Acceptance Date | February 19, 2024 |
| Published in Issue | Year 2024 Volume: 6 Issue: 2 |
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