Öz
Objective: It has been reported that
total cholesterol, triglyceride and low density lipoprotein cholesterol (LDL-C)
increase with menopause, while high-density lipoprotein (HDL-C) gradually decreases.
In this study, we aimed to investigate lipid levels in postmenopausal patients.
Material and Method: Forty-three postmenopausal
women and 43 healthy women were included in the control group and a similar
body-mass index and age group. Blood samples were taken after fasting for 12 hours.
Triglyceride, total cholesterol, and HDL-C plasma concentrations were measured by
cholesterol enzymatic tests, calculated by the LDL-C Friedewald formula.
Results: Triglyceride, total
cholesterol and LDL-C levels were found to be increased during the postmenopausal
period. HDL-C was found to be decreased in postmenopausal period. However,
total cholesterol, LDL-C and HDL-C were not statistically significant.
Triglyceride was statistically significantly higher in postmenopause group compared
to control. When multiple regressions were made, triglyceride elevation in age,
bmi, ggt den were independently detected in postmenopausal women.
Conclusion: Menopause and
triglyceride level sincreased significantly. Total cholesterol and LDL-C levels
did not significantly decrease in HDL-C levels.
Anahtar Kelimeler
Kaynakça
- 1. Menopoz ve Kültür, Öteki YayıneviTolgaErsoy 1998.
- 2. MarshMS, WhiteheadMI.British MedicalBull; Vol48, Issue 2, 1 Jan 1992, Pages 426–57.
- 3. Ahsen Şirin, Menopoz ve Getirdiği Sorunlar,Ege Üniversitesi Hemşirelik Yüksek Okulu Dergi 11: 2, 1995.
- 4. Hotun 1998.
- 5. Wang N, Qin MZ, Cui J.Lipid profile comparisonbetweenpre- and post-menopausalwomen, ZhonghuaXinXueGuanBingZaZhi 2016 Sep 24;44:799-804. doi: 10.3760/cma.j.issn.0253-3758.2016.09.013.
- 6. Taleb-Belkadi O, Chaib H, Zemour L, Fatah A, Chafi B, MekkiK,Lipidprofile, inflammation, andoxidativestatus in peri-andpostmenopausalwomen, GynecolEndocrinol 2016 Dec;32:982-5. Epub 2016 Aug 25.
- 7. Zhang J1, Wang H2, Yang S1, Wang X1,Comparison of lipidprofilesandinflammation in pre- and post-menopausalwomenwithcerebralinfarctionandthe role of atorvastatin in suchpopulations, LipidsHealthDis. 2018 Feb 2;17(1):20. doi: 10.1186/s12944-018-0669-9.
- 8. Teixeira N, Mourits MJ, Oosterwijk JC, et al. Cholesterolprofile in womenwith prematüre menopauseafter riskreducingsalpingo-oophorectomy. FamCancer 2018 Jun 7. doi: 10.1007/s10689-018-0091-5. [Epubahead of print]
- 9. Shah MG, Maibach HI. Estrogenandskin, an overview, Am J ClinDermatol 2001; 2:143-50.
- 10. Palacios S, Henderson VW, Siseles N, Tan D, Villaseca P. Age of menopauseandimpact of climactericsymptomsbygeographicalregion, Climacteric 2010; 13:419–28.
- 11. Çiçek M, Akyürek C, Çelik Ç, Haberal A. Kadın Hastalıkları ve Doğum Bilgisi, Güneş Kitabevi Ankara, 2004; 1163-80.
- 12. Cooney MT, Dudina A, Whincup P, et al. Reevaluatingtheroseapproach: comparativebenefits of thepopulationandhighriskpreventivestrategies. Eur J CardiovascPrevRehabil 2009;16: 541–9.
Öz
Amaç: Menopozla birlikte total
kolesterol, trigliserit ve düşük yoğunluklu lipoprotein
kolesterol (LDL-K) artarken, yüksek yoğunluklu
lipoprotein (HDL-K)’in yavaş yavaş düştüğü bildirilmiştir. Biz bu
çalışmada postmenopozal hastalarda lipit düzeylerini incelemeyi amaçladık.
Gereç ve Yöntem: Çalışmamıza43 postmenopozal kadın ve kontrol
grubu olarak benzer vücut-kitle indeksi (VKİ)ve yaş grubundan 43 sağlıklı kadın
dahil edildi. Kan örnekleri 12 saat açlıktan sonra alındı. Trigliserit, total
kolesterol, HDL-K plazma konsantrasyonları kolesterol enzimatik testlerle
ölçüldü, LDL-K Friedewald'ın formülü ile hesaplandı.
Bulgular: Trigliserit, total kolesterol ve LDL-K
düzeyleri postmenopozal dönemde artmış olarak bulundu. HDL-K postmenopozal
dönemde azalmış olarak bulundu. Ancaktotal kolesterol, LDL-K, HDL-K istatistiksel
olarak anlamlı değildi. Trigliserit postmenopoz grubunda kontrol ile
karşılaştırılınca istatistiksel olarak anlamlı bir şekilde yüksek bulundu. Multipl
regresyon yapıldığında postmenopozal dönemde trigliserit yüksekliği yaş, VKİ,
ggt den bağımsız saptandı.
Sonuç: Menopoz ile trigliserit düzeyindeartış anlamlı
şekilde ilişkiliydi. Total Kolesterol, LDL-K değerlerinde anlamlı
yükselmeler HDL-K düzeyinde anlamlı düşmeler görülmedi.
Anahtar Kelimeler
Kaynakça
- 1. Menopoz ve Kültür, Öteki YayıneviTolgaErsoy 1998.
- 2. MarshMS, WhiteheadMI.British MedicalBull; Vol48, Issue 2, 1 Jan 1992, Pages 426–57.
- 3. Ahsen Şirin, Menopoz ve Getirdiği Sorunlar,Ege Üniversitesi Hemşirelik Yüksek Okulu Dergi 11: 2, 1995.
- 4. Hotun 1998.
- 5. Wang N, Qin MZ, Cui J.Lipid profile comparisonbetweenpre- and post-menopausalwomen, ZhonghuaXinXueGuanBingZaZhi 2016 Sep 24;44:799-804. doi: 10.3760/cma.j.issn.0253-3758.2016.09.013.
- 6. Taleb-Belkadi O, Chaib H, Zemour L, Fatah A, Chafi B, MekkiK,Lipidprofile, inflammation, andoxidativestatus in peri-andpostmenopausalwomen, GynecolEndocrinol 2016 Dec;32:982-5. Epub 2016 Aug 25.
- 7. Zhang J1, Wang H2, Yang S1, Wang X1,Comparison of lipidprofilesandinflammation in pre- and post-menopausalwomenwithcerebralinfarctionandthe role of atorvastatin in suchpopulations, LipidsHealthDis. 2018 Feb 2;17(1):20. doi: 10.1186/s12944-018-0669-9.
- 8. Teixeira N, Mourits MJ, Oosterwijk JC, et al. Cholesterolprofile in womenwith prematüre menopauseafter riskreducingsalpingo-oophorectomy. FamCancer 2018 Jun 7. doi: 10.1007/s10689-018-0091-5. [Epubahead of print]
- 9. Shah MG, Maibach HI. Estrogenandskin, an overview, Am J ClinDermatol 2001; 2:143-50.
- 10. Palacios S, Henderson VW, Siseles N, Tan D, Villaseca P. Age of menopauseandimpact of climactericsymptomsbygeographicalregion, Climacteric 2010; 13:419–28.
- 11. Çiçek M, Akyürek C, Çelik Ç, Haberal A. Kadın Hastalıkları ve Doğum Bilgisi, Güneş Kitabevi Ankara, 2004; 1163-80.
- 12. Cooney MT, Dudina A, Whincup P, et al. Reevaluatingtheroseapproach: comparativebenefits of thepopulationandhighriskpreventivestrategies. Eur J CardiovascPrevRehabil 2009;16: 541–9.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 22 Ocak 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 1 Sayı: 1 |
Kaynak Göster
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Assoc Prof Dr Muhammed KIZILGÜL was qualified as an Associated Editor in ACMJ on 15/02/2020,
Assoc. Prof. Dr. Ercan YUVANÇ leaved, Assoc. Prof. Dr. Alpaslan TANOĞLU became the Editör in Chief in ACMJ on 13/05/2020.