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Relationship between adolescent varicocele and mean platelet volume

Year 2019, Volume: 1 Issue: 1, 9 - 13, 22.01.2019

Engin Kölükçü İlker Etikan Velid Unsal Nihat Uluocak

https://doi.org/10.38053/agtd.500295

Abstract

Objectives:  The aim of this study is to investigate the relationship
between adolescent varicocele and mean platelet volume (MPV).

Materials and
Methods: Patients
were divided into two groups. Group 1 was determined as the control group.
Group 2 consisted of patients between the ages of 11-19 who were diagnosed with
Grade 3 varicocele. MPV values of both groups were statistically compared.

Results: Between January 2012 and
February 2018, 102 patients were included in the study. The mean age of the
patients was 15.12 ± 2.12 years. No statistically significant difference was
found between the two groups in terms of mean ages and their distribution
(p> 0.05). MPV values for Groups 1 and 2 were 8.09 ± 0.69 and 9.65 ± 1.6,
respectively. MPV values measured in Group 2 were significantly higher than
group 1 (p<0.001).







Conclusions: In our study, there was a
significant relationship between adolescent varicocele and MPV. We believe that
MPV elevation can be used as a guide in future studies performed on varicocele
pathophysiology.

Keywords

Adolescent varicocele mean platelet volume

References

  • Referans1- Richardson I, Grotas AB, Nagler HM. Outcomes of varicocelectomy treatment: an updated critical analysis. Urol Clin North Am. 2008;35:191-209. DOI: 10.1016/j.ucl.2008.01.007.
  • Referans2- Dohle GR, Glassberg KI. How common are varicocoeles? New data on the prevalence in adolescence and new discussions. Andrology. 2013;1:661–2. DOI: 10.1111/j.2047-2927.2013.00128.x.
  • Referans3- Akbay E, Cayan S, Doruk E, Bozlu M. The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 2000 ;86(4):490-3.
  • Referans4- Dubin L, Amelar R.D. Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertil Steril. 1970;21:606-60.
  • Referans5- Ersöz G. Platelet Activation. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1997;3:163-172.
  • Referans6- Briggs C, Harrison P, Machin SJ: Continuing developments with the automated platelet count. Int J Lab Haematol. 2007;29:1-15.
  • Referans7- Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol. 2002;118: 787-93. DOI: 10.1309/CQGG-HY0U-LRKL-GLMP.
  • Referans8- Endler G, Klimesch A, Sunder-Plasmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platetet volume is an independent risk factor for myocardial infarction but for coro-nary artery disease. Br J Hmaemotal 2002;117:399-404. DOI: 10.1046/j.1365-2141.2002.03441.x.
  • Referans9- Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arth-ritis. Joint Bone Spine. 2008;75(3):291-4. DOI: 10.1016/j.jbspin. 2007.06.016.
  • Referans10- Beyan C, Beyan E. Mean platelet volume and amyloidosis in patients with familial Medi-terranean fever. Clin Rheumatol. 2013;32(8):1245-6. DOI: 10.1007/s10067-013-2313-4.
  • Referans11- Shilpi K, Potekar RM. A Study of Platelet Indices in Type 2 Diabetes Mellitus Patients. In-dian J Hematol Blood Transfus. 2018;34(1):115-120. DOI: 10.1007/s12288-017-0825.
  • Referans12- Nöske HD, Weidner W. Varicocele–a historical perspective. World J Urol 1999:151-7.
  • Referans13- Erdemir F, Kılıç S. Varicocele. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 2011;3(2):1-11.
  • Referans14- Çayan S, Kadıoğlu A. Current Approaches In The Diagnosis And Treatment Of Varicocele. Turk J Urol. 2005;31(1):57-63.
  • Referans15- Öztürk E, Soygür T. Adölesan varikosel (Derleme). Androloji Bülteni. 2013;53:103-5.
  • Referans16- Kohler FP. On the etiology of varicocele. J Urol. 1967;97(4):741-2.
  • Referans17- Kiliç S, Aksoy Y, Sincer I, Oğuz F, Erdil N, Yetkin E. Cardiovascular evaluation of young patients with varicocele. Fertil Steril. 2007;88(2):369-73. DOI: 10.1016/j.fertnstert.2006.11.119.
  • Referans18- Yetkin E, Kilic S, Acikgoz N, Ergin H, Aksoy Y, Sincer I et al. Increased prevalence of va-ricocele in patients with coronary artery ectasia. Coron Artery Dis. 2005;16(5):261-4.
  • Referans19- Koyuncu H, Ergenoglu M, Yencilek F, Gulcan N, Tasdelen N, Yencilek E et al. The evalua-tion of saphenofemoral insufficiency in primary adult varicocele. J Androl. 2011;32(2):151-4. DOI: 10.2164/jandrol.109.009258.
  • Referans20- Ciaccio V, Ficola F, Ceccarelli F, Capodicasa E. [Assessment of sapheno-femoral junction continence in 42 patients with primary varicocele]. Minerva Chir. 1995;50(5):469-73.
  • Referans21- Özkan MTA, Seyhah S, Özdemir S. Incidence of Venous Insufficiency in Patients with Va-ricocele. International Journal of Clinical Research 2014;2(4):156-9.
  • Referans22- Ayan NN, Savaş Z, Bireroğlu N, Keleş A, Aksoy N, Serin Ö. The Comparison of Platelet Counts between the before and after Treatments of Women with Iron Deficiency Anemia JAREM. 2015; 5: 94-6 DOI: 10.5152/jarem.2015.712.
  • Referans23- Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Meanplatelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47-58.
  • Referans24- Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med. 2007;357:2482-94. DOI: 10.1056/NEJMra071014.
  • Referans25- Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7(2):157-61.
  • Referans26- Toptaş M, Durmuş G, Akkoç İ, Öztürk S, Şahin M, Belen E et al. Are Mean Platelet Volume and Platelet Count Associated with Presence of Thrombus in Patients with Abdominal Aor-tic Aneursym? Med Bull Haseki 2018;56:32-6. DOI: 10.4274/haseki.80299.
  • Referans27- Korkmaz L, Korkmaz AA, Akyüz AR, Ağaç MT, Acar Z, Kırış A. et al. Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: an observational study. Anadolu Kardiyol Derg. 2012;12:35-9.
  • Referans28- Sarıca MA, Kızıldağ B, Selçuk MY, Tutak AŞ, Baykan AH, Bulut HT et al. Mean Platelet Volume in Patients with Chronic Venous Insufficiency. Journal of Clinical and Experimen-tal Investigations 2016;7(1):73-7. DOI: 10.5799/ahinjs.01.2016.01.0573.
  • Referans29- Deveci Ş, Çelebi A, Aşkın S, Gürsoy AE, Kolukısa M, Hakyemez A. Relationship of mean platelet volume to an acute ischemic stroke. Ege Journal of Medicine 2014;53(1):1-6.
  • Referans30- Bozkurt Y, Soylemez H, Sancaktutar AA, Islamoglu Y, Kar A, Penbegul N et al. Relations-hip between mean platelet volume and varicocele: a preliminary study. Urology. 2012;79(5):1048-51. DOI: 10.1016/j.urology.2012.01.019.
  • Referans31- Çoban S, Keleş I, Biyik I, Güzelsoy M, Türkoğlu AR, Özgünay T et al. Is there any relati-onship between mean platelet volume and varicocele? Andrologia. 2015;47(1):37-41. DOI: 10.1111/and.12220.
  • Referans32- Çoban S, Keles I, Biyik İ, Guzelsoy M, Turkoglu AR, Ocak N. Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels? Can Urol Assoc J. 2015;9(1-2):E5-9. DOI: 10.5489/cuaj.2113.
  • Referans33- Mahdavi-Zafarghandi R, Shakiba B, Keramati MR, Tavakkoli M. Platelet volume indices in patients with varicocele. Clin Exp Reprod Med. 2014;41(2):92-5. DOI: 10.5653/cerm.2014.41.2.92.
  • Referans34- Camoglio FS, Peretti M, Bianchi F, Mariotto A, Zampieri N. Mean platelet volume and va-ricocele: comparison between adolescents and adults. Am J Clin Exp Urol. 2015;3(2):100-6.
  • Referans35- Okçelik S, Gök M, Şener İ, Ateş F, Soydan H, Yılmaz Ö et al. The relationship between va-ricocele and mean platelet volume levels is still not clear. The New Journal of Urology 2017;12 (2):17-20.

Adölesan varikosel ile ortalama trombosit hacminin ilişkisi

Year 2019, Volume: 1 Issue: 1, 9 - 13, 22.01.2019

Engin Kölükçü İlker Etikan Velid Unsal Nihat Uluocak

https://doi.org/10.38053/agtd.500295

Abstract

Amaç: Bu çalışmada adölesan varikosel
ile ortalama trombosit hacmi (MPV) arasında ilişkinin araştırılması
hedeflenmiştir.

Gereç ve
Yöntemler: Hastalar
iki grup halinde ele alındı. Grup 1; kontrol
grubu olarak belirlendi. Grup 2 ise 11-19 yaş aralığında grade 3 varikosel
tanısı konulan olgulardan oluşmaktaydı. Her iki grubun MPV değerleri istatiksel
olarak karşılaştırıldı. 

Bulgular: Ocak 2012 ve Şubat 2018
tarihleri arasında 102 hasta çalışmaya dahil edildi. Hastaların yaş ortalaması
15.12 ± 2.12 yıl idi. Her iki grup arasında yaş ortalamaları ve dağımları
açısından istatiksel farklılık izlenmedi (p>0.05). Grup 1 ve 2 için MPV
değerler sırası ile 8.09±0.69 ve 9.65±1.6 
olarak hesaplandı. Grup 2’de ölçülen MPV değeri
grup 1 göre istatiksel olarak anlamlı olarak yüksek izlendi (p<0.001).







Sonuç:
Çalışmamızda adölesan varikosel
ile MPV arasında anlamlı ilişki olduğu gösterilmiştir. Gelecekte varikosel patofizyoloji
hakında yapılacak yeni araştırmalarda MPV yüksekliğinin bir rehber olarak
kullanılabileceğini düşünmekteyiz. 

Keywords

Adölesan varikosel ortalama trombosit hacmi

References

  • Referans1- Richardson I, Grotas AB, Nagler HM. Outcomes of varicocelectomy treatment: an updated critical analysis. Urol Clin North Am. 2008;35:191-209. DOI: 10.1016/j.ucl.2008.01.007.
  • Referans2- Dohle GR, Glassberg KI. How common are varicocoeles? New data on the prevalence in adolescence and new discussions. Andrology. 2013;1:661–2. DOI: 10.1111/j.2047-2927.2013.00128.x.
  • Referans3- Akbay E, Cayan S, Doruk E, Bozlu M. The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 2000 ;86(4):490-3.
  • Referans4- Dubin L, Amelar R.D. Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertil Steril. 1970;21:606-60.
  • Referans5- Ersöz G. Platelet Activation. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1997;3:163-172.
  • Referans6- Briggs C, Harrison P, Machin SJ: Continuing developments with the automated platelet count. Int J Lab Haematol. 2007;29:1-15.
  • Referans7- Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol. 2002;118: 787-93. DOI: 10.1309/CQGG-HY0U-LRKL-GLMP.
  • Referans8- Endler G, Klimesch A, Sunder-Plasmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platetet volume is an independent risk factor for myocardial infarction but for coro-nary artery disease. Br J Hmaemotal 2002;117:399-404. DOI: 10.1046/j.1365-2141.2002.03441.x.
  • Referans9- Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arth-ritis. Joint Bone Spine. 2008;75(3):291-4. DOI: 10.1016/j.jbspin. 2007.06.016.
  • Referans10- Beyan C, Beyan E. Mean platelet volume and amyloidosis in patients with familial Medi-terranean fever. Clin Rheumatol. 2013;32(8):1245-6. DOI: 10.1007/s10067-013-2313-4.
  • Referans11- Shilpi K, Potekar RM. A Study of Platelet Indices in Type 2 Diabetes Mellitus Patients. In-dian J Hematol Blood Transfus. 2018;34(1):115-120. DOI: 10.1007/s12288-017-0825.
  • Referans12- Nöske HD, Weidner W. Varicocele–a historical perspective. World J Urol 1999:151-7.
  • Referans13- Erdemir F, Kılıç S. Varicocele. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 2011;3(2):1-11.
  • Referans14- Çayan S, Kadıoğlu A. Current Approaches In The Diagnosis And Treatment Of Varicocele. Turk J Urol. 2005;31(1):57-63.
  • Referans15- Öztürk E, Soygür T. Adölesan varikosel (Derleme). Androloji Bülteni. 2013;53:103-5.
  • Referans16- Kohler FP. On the etiology of varicocele. J Urol. 1967;97(4):741-2.
  • Referans17- Kiliç S, Aksoy Y, Sincer I, Oğuz F, Erdil N, Yetkin E. Cardiovascular evaluation of young patients with varicocele. Fertil Steril. 2007;88(2):369-73. DOI: 10.1016/j.fertnstert.2006.11.119.
  • Referans18- Yetkin E, Kilic S, Acikgoz N, Ergin H, Aksoy Y, Sincer I et al. Increased prevalence of va-ricocele in patients with coronary artery ectasia. Coron Artery Dis. 2005;16(5):261-4.
  • Referans19- Koyuncu H, Ergenoglu M, Yencilek F, Gulcan N, Tasdelen N, Yencilek E et al. The evalua-tion of saphenofemoral insufficiency in primary adult varicocele. J Androl. 2011;32(2):151-4. DOI: 10.2164/jandrol.109.009258.
  • Referans20- Ciaccio V, Ficola F, Ceccarelli F, Capodicasa E. [Assessment of sapheno-femoral junction continence in 42 patients with primary varicocele]. Minerva Chir. 1995;50(5):469-73.
  • Referans21- Özkan MTA, Seyhah S, Özdemir S. Incidence of Venous Insufficiency in Patients with Va-ricocele. International Journal of Clinical Research 2014;2(4):156-9.
  • Referans22- Ayan NN, Savaş Z, Bireroğlu N, Keleş A, Aksoy N, Serin Ö. The Comparison of Platelet Counts between the before and after Treatments of Women with Iron Deficiency Anemia JAREM. 2015; 5: 94-6 DOI: 10.5152/jarem.2015.712.
  • Referans23- Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Meanplatelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47-58.
  • Referans24- Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med. 2007;357:2482-94. DOI: 10.1056/NEJMra071014.
  • Referans25- Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7(2):157-61.
  • Referans26- Toptaş M, Durmuş G, Akkoç İ, Öztürk S, Şahin M, Belen E et al. Are Mean Platelet Volume and Platelet Count Associated with Presence of Thrombus in Patients with Abdominal Aor-tic Aneursym? Med Bull Haseki 2018;56:32-6. DOI: 10.4274/haseki.80299.
  • Referans27- Korkmaz L, Korkmaz AA, Akyüz AR, Ağaç MT, Acar Z, Kırış A. et al. Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: an observational study. Anadolu Kardiyol Derg. 2012;12:35-9.
  • Referans28- Sarıca MA, Kızıldağ B, Selçuk MY, Tutak AŞ, Baykan AH, Bulut HT et al. Mean Platelet Volume in Patients with Chronic Venous Insufficiency. Journal of Clinical and Experimen-tal Investigations 2016;7(1):73-7. DOI: 10.5799/ahinjs.01.2016.01.0573.
  • Referans29- Deveci Ş, Çelebi A, Aşkın S, Gürsoy AE, Kolukısa M, Hakyemez A. Relationship of mean platelet volume to an acute ischemic stroke. Ege Journal of Medicine 2014;53(1):1-6.
  • Referans30- Bozkurt Y, Soylemez H, Sancaktutar AA, Islamoglu Y, Kar A, Penbegul N et al. Relations-hip between mean platelet volume and varicocele: a preliminary study. Urology. 2012;79(5):1048-51. DOI: 10.1016/j.urology.2012.01.019.
  • Referans31- Çoban S, Keleş I, Biyik I, Güzelsoy M, Türkoğlu AR, Özgünay T et al. Is there any relati-onship between mean platelet volume and varicocele? Andrologia. 2015;47(1):37-41. DOI: 10.1111/and.12220.
  • Referans32- Çoban S, Keles I, Biyik İ, Guzelsoy M, Turkoglu AR, Ocak N. Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels? Can Urol Assoc J. 2015;9(1-2):E5-9. DOI: 10.5489/cuaj.2113.
  • Referans33- Mahdavi-Zafarghandi R, Shakiba B, Keramati MR, Tavakkoli M. Platelet volume indices in patients with varicocele. Clin Exp Reprod Med. 2014;41(2):92-5. DOI: 10.5653/cerm.2014.41.2.92.
  • Referans34- Camoglio FS, Peretti M, Bianchi F, Mariotto A, Zampieri N. Mean platelet volume and va-ricocele: comparison between adolescents and adults. Am J Clin Exp Urol. 2015;3(2):100-6.
  • Referans35- Okçelik S, Gök M, Şener İ, Ateş F, Soydan H, Yılmaz Ö et al. The relationship between va-ricocele and mean platelet volume levels is still not clear. The New Journal of Urology 2017;12 (2):17-20.
There are 35 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Article
Authors

Engin Kölükçü 0000-0003-3387-4428

İlker Etikan This is me 0000-0001-9171-8269

Velid Unsal 0000-0003-1415-0563

Nihat Uluocak This is me 0000-0001-8315-466X

Publication Date January 22, 2019
Published in Issue Year 2019 Volume: 1 Issue: 1

Cite

APA Kölükçü, E., Etikan, İ., Unsal, V., Uluocak, N. (2019). Relationship between adolescent varicocele and mean platelet volume. Anadolu Güncel Tıp Dergisi, 1(1), 9-13. https://doi.org/10.38053/agtd.500295
AMA Kölükçü E, Etikan İ, Unsal V, Uluocak N. Relationship between adolescent varicocele and mean platelet volume. Anatolian Curr Med J. January 2019;1(1):9-13. doi:10.38053/agtd.500295
Chicago Kölükçü, Engin, İlker Etikan, Velid Unsal, and Nihat Uluocak. “Relationship Between Adolescent Varicocele and Mean Platelet Volume”. Anadolu Güncel Tıp Dergisi 1, no. 1 (January 2019): 9-13. https://doi.org/10.38053/agtd.500295.
EndNote Kölükçü E, Etikan İ, Unsal V, Uluocak N (January 1, 2019) Relationship between adolescent varicocele and mean platelet volume. Anadolu Güncel Tıp Dergisi 1 1 9–13.
IEEE E. Kölükçü, İ. Etikan, V. Unsal, and N. Uluocak, “Relationship between adolescent varicocele and mean platelet volume”, Anatolian Curr Med J, vol. 1, no. 1, pp. 9–13, 2019, doi: 10.38053/agtd.500295.
ISNAD Kölükçü, Engin et al. “Relationship Between Adolescent Varicocele and Mean Platelet Volume”. Anadolu Güncel Tıp Dergisi 1/1 (January 2019), 9-13. https://doi.org/10.38053/agtd.500295.
JAMA Kölükçü E, Etikan İ, Unsal V, Uluocak N. Relationship between adolescent varicocele and mean platelet volume. Anatolian Curr Med J. 2019;1:9–13.
MLA Kölükçü, Engin et al. “Relationship Between Adolescent Varicocele and Mean Platelet Volume”. Anadolu Güncel Tıp Dergisi, vol. 1, no. 1, 2019, pp. 9-13, doi:10.38053/agtd.500295.
Vancouver Kölükçü E, Etikan İ, Unsal V, Uluocak N. Relationship between adolescent varicocele and mean platelet volume. Anatolian Curr Med J. 2019;1(1):9-13.
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