Fathers That Are Born Small Program Alterations in the Next-Generation Preimplantation Rat Embryos1,2
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Key Words
preimplantation rat blastocyst
uteroplacental insufficiency
transgenerational transmission
growth restriction
paternal line
Abbreviations
F0
generation naught, normal female or male animals
F1
first-generation
F2
second-generation
G2
second-stage blastocyst culture growth
GMOPS
3-morpholinopropane-1-sulfonic acid-buffered first-stage blastocyst culture growth
HSA
human serum albumin
ICM
inner cell mass
mTOR
mammalian target of rapamycin
Pi3k
phosphoinositide 3 kinase
restricted
offspring born of low birth weight after bilateral uterine vessel ligation surgery
1H-NMR
hydrogen-1 nuclear magnetic resonance
Cited by (0)
- 1
Supported by NHMRC project grant (to DKG and MEW), NHMRC Early Career Research fellowship (to NJH), Fay Marles Scholarship from The University of Melbourne (to JSM), and an MMI-CSIRO scholarship (to JSM).
- 2
Author disclosures: JS Master, GA Thouas, AJ Harvey, JR Sheedy, NJ Hannan, DK Gardner, and ME Wlodek, no conflicts of interest. The funding entity did not have a role in the design, implementation, analysis, or interpretation of the data. The findings and conclusions in this report are those of the authors.
Copyright © 2015 American Society of Nutrition. Published by Elsevier Inc. All rights reserved.