A new trial method for complete dentures using rapid prototyping (RP) was compared with the conventional method. Wax dentures were fabricated for 10 edentulous patients. Cone-beam CT was used to scan the wax dentures. Using 3D computer-aided design software, seven 3D denture images with different artificial teeth arrangements were made and seven trial dentures per patient were fabricated accordingly. Two prosthodontists performed a denture try-in for one patient using both conventional and RP methods. The prosthodontists and patients rated satisfaction for both methods using a visual analogue scale. Satisfaction ratings with both conventional and RP methods were compared using the Wilcoxon signed-rank test. Regarding prosthodontist’s ratings, esthetics and stability were rated significantly higher with the conventional method than with the RP method, whereas chair time was rated significantly longer with the RP method than with the conventional method. Although further improvements are needed, the trial method applying RP seems promising.