Effect of Dry Binders on Mechanical Properties of Ketoprofen-Cyclodextrin Extended Drug Release Systems

Monica Cretan  Stamate; Carmen Gafitanu; Ciprian Stamate; Eliza Gafitanu

doi:10.4028/www.scientific.net/AMM.186.143

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 186Effect of Dry Binders on Mechanical Properties of...

Effect of Dry Binders on Mechanical Properties of Ketoprofen-Cyclodextrin Extended Drug Release Systems

Abstract:

In this paper, the mechanical properties of extended drug release systems were studied. A binder is a material that is added to a formulation in order to improve the mechanical strength of a drug release system. The drug release systems investigated were cylindrical tablets containing mixtures of various ketoprofen types and binders. Among the binders used were a series of different molecular weights of kollidon va 64, carbopol 971 pnf, hydroxypropyl methyl cellulose and sodium carboxyl methyl cellulose. The samples were made in the form of cylindrical tablet of about 9 mm in diameter and containing different mixtures of drug substances and excipients in three formulations. Mechanical parameters such as hardness, tensile stress and friability were studied in order to determine how they are influenced by binder and how it influences wetting and disintegration of tables.

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Periodical:

Applied Mechanics and Materials (Volume 186)

Pages:

143-148

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.186.143

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Cite this paper

Online since:

June 2012

Authors:

Monica Cretan Stamate, Carmen Gafitanu, Ciprian Stamate, Eliza Gafitanu

Keywords:

Extended Drug Release, Friability, Hardness, Ketoprofen, Mechanical Strength

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