Synthesis and SEM Analysis of Ketoprofen-Hidroxipropil-β-Cyclodextrin Microparticles for Medical Applications as Drug-Release System with a High Bioavailability

Monica Stamate Cretan; Corneliu Munteanu; Eliza Gafitanu; Andreea Carmen Barbinta; Ciprian Stamate

doi:10.4028/www.scientific.net/AMM.325-326.106

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 325-326Synthesis and SEM Analysis of...

Synthesis and SEM Analysis of Ketoprofen-Hidroxipropil-β-Cyclodextrin Microparticles for Medical Applications as Drug-Release System with a High Bioavailability

Abstract:

Drug-release systems are studied lately for increasing absorption in the body and improve the therapeutic effectiveness is key objective. Whatever form it may take a drug release system: tablet, implant, injectable suspension or transdermal system, the basic unit on which effective therapeutic drug particle. Knowledge of particle size distribution in a disperse system is of great importance in pharmaceutical technology. The size, surface area and volume-surface particle may be relevant to the physical, chemical and pharmacological drug toxicities. Stability and speed of dissolution of ketoprofen are much reduced in pure and coupled with a solubility promoter, enhances the bioavailability and particle size distribution depends. In order to improve absorption properties of ketoprofen were synthesized drug microparticles containing ketoprofen and hydroxypropyl beta cyclodextrin. Drug microparticles were studied by SEM microscopy and the results correlated with solubility properties. It was found that microparticles obtained are more easily soluble than pure ketoprofen and small size increases bioavailability.

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Periodical:

Applied Mechanics and Materials (Volumes 325-326)

Pages:

106-110

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.325-326.106

Citation:

Cite this paper

Online since:

June 2013

Authors:

Monica Stamate Cretan, Corneliu Munteanu, Eliza Gafitanu, Andreea Carmen Barbinta, Ciprian Stamate

Keywords:

Bioavailability, Cyclodextrin, Dimensions, Ketoprofen, Microparticles

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