Preparation Technique of Technetium-99m-Labeled Nanoparticles of Fe@C with Modified Surface

Viktor S. Skuridin; Elena S. Stasyuk; Alexander S. Rogov; Natalya V. Varlamova; Evgeny A. Nesterov; Vladimir L. Sadkin; Pavel S. Postnikov

doi:10.4028/www.scientific.net/AMR.1084.582

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1084Preparation Technique of Technetium-99m-Labeled...

Preparation Technique of Technetium-99m-Labeled Nanoparticles of Fe@C with Modified Surface

Abstract:

The authors have researched the possibility of radioactive ^99mTc labeling of the surface of carbon-coated nano-sized ferrum Fe@C particles as well as Fe@C (IDA) particles modified by aryldiazonium tosilates. Non-modified particles proved to absorb up to 11.2 % of ^99mТс injected amount. The value of atomic absorption does not exceed 0.736∙10^-9 g-at ^99mТс per 1 g of Fe@C. No physical absorption is observed on modified particles of Fe@C (IDA). In chemical interaction of the particles with ^99mTc in the presence of a reducing agent, Sn (II), the yield of the labeled product increases 1.5 times and reaches 21.3% of the total induced radioactivity of the radionuclide.

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Periodical:

Advanced Materials Research (Volume 1084)

Pages:

582-586

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1084.582

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Online since:

January 2015

Authors:

Viktor S. Skuridin, Elena S. Stasyuk, Alexander S. Rogov, Natalya V. Varlamova, Evgeny A. Nesterov, Vladimir L. Sadkin, Pavel S. Postnikov

Keywords:

Nanocolloids, Nanoparticle, Technecium-99m

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References

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