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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 749A Molecular Dynamics Study of the Cyanobacterial...

A Molecular Dynamics Study of the Cyanobacterial Clock Protein KaiA

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Abstract:

Regulation of daily physiological functions with a ~24-hour periodicity, or circadian rhythms, exists in both eukaryotes and prokaryotes. So far, cyanobacteria are only known prokaryotes proved to have circadian rhythmicity. The circadian system in cyanobacteria comprises a post-translational oscillator (PTO) and a transcriptional/translational feedback loop (TTFL). The PTO comprise of three proteins (KaiA, KaiB, KaiC), and can be reconstituted in vitro with the existence of ATP. Phase of the PTO is associated with the phosphorylation states of KaiC, with KaiA promoting the phosphorylation of KaiC, and KaiB promoting the de-phosphorylation. Here we studied the dynamics of the KaiA protein of Thermosynechococcus elongatus. The result will be helpful in understanding the function of KaiA and its binding with KaiC.

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Bio-Medical Materials and Engineering

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Periodical:

Advanced Materials Research (Volume 749)

Pages:

338-343

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.749.338

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Online since:

August 2013

Authors:

Liu Sen, Dong Pei

Keywords:

Clock Proteins, Cyanobacteria, KaiA, Molecular Dynamic (MD)

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