In Vivo Biocompatibility Studies of Nano TiO2 Materials

Wei Han; Yue Dan Wang; Yu Feng Zheng

doi:10.4028/www.scientific.net/AMR.79-82.389

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 79-82In Vivo Biocompatibility Studies of Nano TiO2...

In Vivo Biocompatibility Studies of Nano TiO₂ Materials

Abstract:

TiO2 nanomaterials with different dimensions(zero and one), sizes(20nm, 50nm and 100nm in diameter) and crystal structures(100% rutile, 100% anatase and combination of 20% rutile and 80% anatase) were confected to suspensions and ointment with varied concentrations and evaluated in animal model (Balb-c mouse). These mouse were divided into various groups randomly, with suspension intraperitoneally injected or ointment transdermally daubed. Heart, lung, liver and kidney were collected and prepared to HE sample after one week. Spectrophotometry was applied to study total antioxide capability and catalase activity of blood and tissues. It has been shown that all TiO2 nanomaterial groups had no effect on lives’ morphology and oxidative stress, with no obvious histopathological changes observed in heart, lung, liver and kidney, and these tissues presented no vacuolar degeneration, necrosis edema, engorgement and inflammation.

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Info:

Periodical:

Advanced Materials Research (Volumes 79-82)

Pages:

389-392

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.79-82.389

Citation:

Cite this paper

Online since:

August 2009

Authors:

Wei Han, Yue Dan Wang, Yu Feng Zheng

Keywords:

Biocompatibility, In Vivo, Morpholoy, Oxidative Stress Level

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