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HomeJournal of Biomimetics, Biomaterials and Tissue...Journal of Biomimetics, Biomaterials and Tissue...Development of 3D Antibiotic-Eluting Bioresorbable...

Development of 3D Antibiotic-Eluting Bioresorbable Scaffold with Attenuating Envelopes

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Abstract:

Thick Section 3D Bioresorbable Scaffolds Are Proposed as a Potential Alternative to Biologic Skin Grafts and Supportive Fillers for Non-Healing Chronic Wound Ulcers. Synthetic Bioresorbable Scaffolds Avoid Human and Animal Derived Contamination Risks, Provide Feasible Shelf Life, Availability and Cost, and Act as a Consistent Platform for Localized Drug Elution. A Bioresorbable Polyester-Based Scaffold (Infilon™) Was Investigated as a Drug Delivery Vehicle for Chloramphenicol Antibiotic (CAP) Combined with a Bioactive Envelope. the Effect of Varying Envelope Protocols on Antibiotic Elution Profile and Antimicrobial Potency on Scaffolds Were Analysed. the Maximum Antibiotic Loading Efficiency of the Scaffold Was 10.18% W/w. the Antibiotic Elution Profile Showed that the Burst Phase Lasted One Hour Subsequent to a Sustained Phase Approaching near Asymptotic Release. Envelope Permutations of Bulk Metallic Glass (BMG) and Bioglass 45S5 Reduced the Total Amount of Antibiotic Released by 1 to 1.8 Mg while the Polyethylene Oxide Envelope Extended the Burst Phase to 2 Hours. CAP Loaded Scaffolds Demonstrated Antimicrobial Effectiveness for 24 Hours. Results Show Potential for the Infilon™ Scaffold to Be Used as a Platform for Localized Antibiotic Delivery. Delivery Profiles Can Be Enhanced with Additional BMG or Bioglass Envelopes. this Approach Has Opportunity to Provide a Synergistic Coupling of Antimicrobial Action and the Harbouring of Granular Tissue Subsequent to Final Wound Healing.

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Journal of Biomimetics, Biomaterials & Tissue Engineering Vol. 15

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Periodical:

Journal of Biomimetics, Biomaterials and Tissue Engineering (Volume 15)

Pages:

55-62

DOI:

https://doi.org/10.4028/www.scientific.net/JBBTE.15.55

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Online since:

October 2012

Authors:

Benjamin Chow, Alex Baume, Peter Lok, Jake Cao, Nick Coleman, Andrew J. Ruys, Philip Boughton

Keywords:

3D Scaffolds, Antibiotic Elution Profile, Antimicrobial, Bioglass 45S5, Bulk Metallic Glass (BMG), Infilon™, Loading Efficiency, Poly (Ethylene Oxide), Scaffold Envelope

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