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    Korean J Urol. 2007 Jun;48(6):638-645. Korean.
    Published online Jun 30, 2007.
    https://doi.org/10.4111/kju.2007.48.6.638
    Copyright © 2007 The Korean Urological Association
    Original Article

    A Recent Study on the Antimicrobial Sensitivity of the Organisms that Cause Urinary Tract Infection

    Kwang Ho Ryu, Myung Ki Kim, and Young Beom Jeong1
      • Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
      • 1Department of Urology, Chonbuk National University Medical School, Jeonju, Korea.
    • Corresponding author (Email: mg20042001@yahoo.co.kr )
    Received January 23, 2007; Accepted May 08, 2007.

    Abstract

    Purpose

    The overuse and misuse of antimicrobial agents have made choosing an appropriate antibiotic more difficult. We studied changes in the antibiotic sensitivities of the causative microorganisms of urinary tract infection (UTI), in 2000 versus 2005, in order to provide useful information and to aid physicians to make better choices of adequate drugs for treating UTI.

    Materials and Methods

    We retrospectively analyzed 5,266 uropathogens and their antimicrobial sensitivities in 3,346 patients who were admitted to or they had visited two tertiary hospitals located in Honam province, in 2000 versus 2005. This revealed the isolated causative organisms in the urine cultures.

    Results

    The incidence of UTI shows bimodal peaks in the first decade (22.3%) and 7th decade (18.8%). The common pathogens were E. coli (34.4%), Enterococcus (19.0%), Staphylococcus (10.2%), Pseudomonas (9.9%) and Klebsiella (9.8%). The incidence of Gram positive organisms was increased from 35.7% in 2000 to 38.1% by 2005. For the Gram negative isolates, imipenem and amikacin showed relatively higher sensitivity, while ampicillin and ciprofloxacin showed relatively lower sensitivity. For the Gram positive isolates, vancomycin and teicoplanin showed relatively higher sensitivity, while penicillin and ciprofloxacin showed relatively lower sensitivity. Significant declines for the third-generation cephalosporins' and fluoquinolones' sensitivity to E. coli and Klebsiella isolates were found.

    Conclusions

    E. coli was the most common single organism causing UTI. We should be concerned about the increase of Gram positive organisms, especially Enterococcus. The use of TMP/SMX and nitrofurantoin as the first choices of treatment for UTI should be reconsidered. It is recommended that fluoroquinolone should be restricted because of the high antibiotic resistance and the economic aspects.

    Keywords
    Urinary tract infection; Antibiotics; Sensitivity

    Figures

    Fig. 1
    Age and gender distribution of the urinary tract infections.

    Tables

    Table 1
    Species distribution of the isolates from patients with urinary tract infections for 2000 versus 2005

    Table 2
    Changes of drug sensitivities for the Gram stained pathogens for 2000 versus 2005

    Table 3
    Antibiotic sensitivities of the Gram-negative organisms in inpatients

    Table 4
    Antibiotic sensitivities of the Gram-positive organisms in inpatients

    Table 5
    Antibiotic sensitivities of the Gram-negative organisms in outpatients

    Table 6
    Antibiotic sensitivities of the Gram-positive organisms in outpatients

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    MeSH Terms
    Amikacin
    Ampicillin
    Anti-Bacterial Agents
    Anti-Infective Agents
    Ciprofloxacin
    Drug Resistance, Microbial
    Enterococcus
    Humans
    Imipenem
    Incidence
    Klebsiella
    Nitrofurantoin
    Penicillins
    Pseudomonas
    Retrospective Studies
    Staphylococcus
    Teicoplanin
    Tertiary Care Centers
    Urinary Tract Infections*
    Urinary Tract*
    Vancomycin
    Metrics
    Share
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