Home 
Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.3, p.172–177, 2022
Bratislava Medical Journal 2022 Bratislava Medical Journal Vol.123, No.3, p.172–177, 2022
Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Bratislava Medical Journal Vol.123, No.3, p.172–177, 2022 |
||
| Title: Goldfish as a model for studying the effect of hypernatremia on blood plasma lipoproteins | ||
| Author: Alla M. ANDREEVA, Vladimir MARTEMYANOV, Alexey S. VASILIEV, Ilya Yu TOROPYGIN, Nina LAMASH, Darina V GARINA, Dmitry PAVLOV | ||
| Abstract: AIM: To evaluate the effect of hypernatremia on the organization of blood plasma high density lipoproteins (HDL) in goldfish; to compare the state of hypernatremia in fish and humans; to assess the possible risks and consequences of the effect of hypernatremia on human plasma lipoproteins. METHODS: The fish were acclimated for 20 days at a critical salinity of 11.5 g/L; after that the salt water was gradually “desalinated”. The concentration of Na+ and the content of total water were determined in tissues, cells, and body fluids. The HDL organization was assessed by the number of apolipoprotein molecules per particle. The methods of flame spectrophotometry, electrophoresis and MALDI were used. RESULTS: In fresh water, the state of normonatremia was maintained in the fish body; at critical water salinity, the state of hypernatremia. Against the background of hypernatremia, the initial signs of muscle and erythrocyte dehydration appeared in fish, the total water content in the plasma did not change, and HDL disintegrated into small particles, which, upon restoration of normonatremia, were combined into the original large forms. CONCLUSION: In goldfish at the state of normonatremia, large forms of HDL are stable while at the state of hypernatremia, the small forms of HDL are stable. Under conditions of a hypertonic environment and plasma hypernatremia, the breakdown of HDL prevents the loss of water from the fish organism and reduces the threat of their dehydration. Human hypernatremia is characterized by plasma sodium levels comparable to that in goldfish, however accompanied by life-threatening metabolic changes. The results of this study may be useful for assessing the risks of HDL breakdown at hypernatremia and for the development of protocols for the treatment of pathological conditions in humans (Fig. 4, Ref. 45). |
||
| Keywords: goldfish, blood plasma high density lipoproteins, hypernatremia | ||
| Published online: 15-Feb-2022 | ||
| Year: 2022, Volume: 123, Issue: 3 | Page From: 172, Page To: 177 | |
| doi:10.4149/BLL_2022_028 |
||
|
|
 download file |
|