ICJIM
Intercontinental Journal of Internal Medicine

The Intercontinental Journal of Internal Medicine aims to publish issues related to all fields of internal medicine of the highest scientific and clinical value at an international level and accepts articles on these topics. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Obesity: etiology and the problems it causes
Abstract
Obesity is one of the biggest health problems today and its prevalence is increasing. It develops with excessive fat accumulation in the body secondary to high energy intake in obesity. It is a chronic disease in which the interaction of genetic, endocrine, metabolic, behavioral, psychological and sociocultural factors plays a role. In addition to endocrine (type 2 diabetes mellitus and insulin resistance, metabolic syndrome, etc.), cardiovascular (hypertension, hyperlipidemia, etc.) and cerebrovascular diseases, diseases such as cholecystitis, sleep apnea, osteoarthritis, hyperuricemia and gout, endometrial, breast, gallbladder cancers in women are associated with diseases such as colon, rectum, prostate cancer in men. These diseases both reduce the quality of life and lead to financial losses in individuals and national economies. Today, preventive health policies aim to reduce morbidity, mortality and economic burden by treating obesity without causing chronic diseases.

Keywords : Obesity, morbid obesity, obesity diagnosis, obesity prevention, body mass index

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1. World Health Organization. Obesity: preventing and managing theglobal epidemic. World Health Organization. 2000.
2. Taşan E. Obezitenin tanımı, değerlendirme yöntemleri veepidemiyolojisi. Türkiye Klinikleri J Int Med Sci. 2005.1(37:1-4.
3. Serter R. Obezite Atlası. Ankara, Karakter Color Basımevi, 2004.
4. TEMD Obezite, Lipid Metabolizma, Hipertansiyon ÇalışmaGrubu. Obezite Tanı ve Tedavi Kılavuzu. Türkiye Endokrinoloji veMetabolizma Derneği, Mayıs, 2018. 6. Baskı (Güncellenmiş baskı ): p.( 1- 112 ).
5. Kiliç T. Obezite ile iliskili oksidatif stresin altinda yatan mekanizmalar:Leptin ve adiponektinin rolü/Mechanisms underlying obesityassociated oxidative stress: the role of leptin and adiponectin. AnadoluKardiyoloji Dergisi: AKD. 2010;10(5):397.
6. Collaboration N.R.F. Trends in adult body-mass index in 200 countriesfrom 1975 to 2014: a pooled analysis of 1698 population-basedmeasurement studies with 19· 2 million participants. Lancet. 2016;387(10026):1377-1396.
7. The GBD 2015 Obesity Collaborators, Health effects of overweight andobesity in 195 countries over 25 years. New Engl J Med. 2017;377(1):13-27.
8. WHO fact sheet on overweight and obesity. World Health Organization.Updated October 2017. http://www.who.int/mediacentre/factsheets/fs311/en/.
9. Hruby A, Hu FB. The epidemiology of obesity: a big picture.Pharmacoeconomics. 2015;33(7): 673-689.
10. (TUIK), T.İ.K. Adrese Dayalı Nufus Kayıt Sistemi 2016.
11. De Koning L, Merchant AT, Pogue J, Anand SS. Waist circumferenceand waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies. Eur Heart J. 2007;28(7):850-856.
12. Salmi JA. Body composition assessment with segmental multifrequencybioimpedance method. J Sports Sci Med. 2003;2(a00101s1):1-29.
13. Seidell J, Deurenberg P, Hautvast JA. Obesity and fat distributionin relation to health—current insights and recommendations. In:Nutritional Disorders and Requirements. 1987, Karger Publishers. p.57-91.
14. Després JP, Is visceral obesity the cause of the metabolic syndrome?Annals of Medicine. 2006; 38(1):52-63.
15. World Health Organization. Waist circumference and waist-hip ratio:report of a WHO Expert Consultation, Geneva, 8-11 December 2008.(2011).
16. Peppa M, Stefanaki C, Papaefstathiou A, Boschiero D, DimitriadisG, Chrousos GP. Bioimpedance analysis vs. DEXA as a screeningtool for osteosarcopenia in lean, overweight and obese Caucasianpostmenopausal females. Hormones (Athens). 2017;16:181-193.
17. Björntorp P. International Textbook of Obesity Türkçe, 1.Baskı,İstanbul: And Yayıncılık. 2002.
18. Sitil A, Çavdar C, Yeniçerioğlu Y, Çömlekçi A. Vücut kompozisyonunudeğerlendirmede kullanılan yöntemler ve kronik böbrek yetmezliklihastalardaki uygulama alanları. Türk Nefroloji Diyaliz veTransplantasyon Dergisi. 2002;11(4):189-190.
19. Lauria MW, Moreira LMP, Machado-Coelho GL, Neto RM, SoaresM. Ramos A. Ability of body mass index to predict abnormal waistcircumference: receiving operating characteristics analysis. Diabetology& Metabolic Syndrome. 2013;5(1):74.
20. Sonmez A, Bayram F, Barcin C, Ozsan M, Kaya A, Gedik V. Waistcircumference cut off points to predict obesity, metabolic syndromeand cardiovascular risk in Turkish adults. Int J Endocrinol.2013;2013:767202. doi: 10.1155/2013/767202
21. H.Ü.S.B.F. Beslenme ve Diyetetik Bölümü, Türkiye Beslenme ve SağlıkAraştırması 2010. Ankara, Sağlık Bakanlığı Yayınları, 2010: p. 445-95.
22. Onat A. Türkiye’de obezitenin kardiyovasküler hastalıklara etkisi.Türk Kardiyoloji Derneği Arşivi. 2003;31(5):279-289.
23. Türkiye nüfus ve sağlık araştırması, 2008. Hacettepe Üniversitesi Nüfus Etütleri Enstitüsü, Sağlık Bakanlığı Ana Çocuk Sağlığı ve AilePlanlaması Genel Müdürlüğü, Başbakanlık Devlet Planlama TeşkilatıMüsteşarlığı ve TÜBİTAK, Ankara, Türkiye, 2009. 2009: p. 144-45.
24. Sucaklı MH, Çelik M. Obezite etiyolojisi ve epidemiyolojisi. TurkiyeKlinikleri J Fam Med Special Topics. 2015;6(3):1-6.
25. Clement K, Boutin P, Froguel P. Genetics of obesity. Am JPharmacogenomics. 2002;2(3):177-187.
26. Kebapçı N. Obezite genetiği. Turkiye Klinikleri J Int Med Sci.2005;1(37):9-13.
27. Fall T, Ingelsson E. Genome-wide association studies of obesityand metabolic syndrome. Molecular and Cellular Endocrinology.2014;382(1):740-757.
28. Altunkaynak BZ, Özbek E. Obezite: nedenleri ve tedavi seçenekleri.Van Tıp Dergisi. 2006;13(4): 138-142.
29. Bray G. Obesity is a chronic, relapsing neurochemical disease. Int JObesity. 2004;28(1):34.
30. Semin İ. Obezite fizyolojisi. Archives of Clinical Toxicology. 2014:1-7.
31. Gnessi L. Obesity and metabolic comorbidities: environmentaldiseases? Oxidative Medicine and Cellular Longevity. 2013.2013.
32. Erel C. Sağlıklı beslenelim kalbimizi koruyalım projesi araştırmaraporu. TC Sağlık Bakanlığı Temel Sağlık Hizmetleri GenelMüdürlüğü. Ankara: Gürler Matbaası, 2004.
33. Rush E, Yan M. Evolution not revolution: nutrition and obesity.Nutrients. 2017;9(5):519.
34. Hruby A, Hu FB. The epidemiology of obesity: a big picture.Pharmacoeconomics. 2015;33(7): 673-689.
35. Değirmenci T, Kalkan-Oğuzhanoğlu N, Sözeri-Varma G, Özdel O,Fenkci S. Psychological symptoms in obesity and related factors. NöroPsikiyatri Arşivi. 2015;52(1):42.37.
36. Hargens TA, Kaleth AS, Edwards ES, Butner KL. Association betweensleep disorders, obesity, and exercise: a review. Nature and Sscience ofSleep. 2013;5:27.
37. Yumuk V, Tsigos C, Fried M, et al., European guidelines for obesitymanagement in adults. Obesity Facts. 2015;8(6):402-424.
38. Karabayraktar T, Sargın M. Obezite ve Diyabet. Turkiye Klinikleri JFam Med Special Topics. 2015;6(3):29-32.
39. Bays HE, Toth PE, Kris Etherton PP, et al., Obesity, adiposity,and dyslipidemia: a consensus statement from the National LipidAssociation. J Clin Lipidol. 2013;7(4):304-383.
40. Mandviwala T, Khalid U, Deswal A. Obesity and cardiovasculardisease: a risk factor or a risk marker? Current Atherosclerosis Reports.2016;18(5):21.
41. D’agostino RB, Vasan RS, Pencina MJ, et al. General cardiovascularrisk profile for use in primary care: the Framingham Heart Study.Circulation. 2008;117(6):743-753.
42. Mozumdar A, Liguori G. Persistent increase of prevalence of metabolicsyndrome among US adults: NHANES III to NHANES 1999-2006.Diabetes Care. 2011;34(1):216-219.
43. Horvath K, Jeitler K, Siering U, et al. Long-term effects of weight-reducing interventions in hypertensive patients: systematic review andmeta-analysis. Archives of Internal Medicine. 2008; 168(6):571-580.
44. Ertekin YH, Şahin MK, Yarış F. Obezite ve obstrüktif uyku apnesendromu. Turkiye Klinikleri J Fam Med Special Topics. 2015;6(3):60-64.
45. Peker AGC, Dabak R, Ungan M. Birinci basamakta obezite vegastrointestinal sistem hastalıkları. Turkiye Klinikleri J Fam MedSpecial Topics. 2015;6(3):54-59.47.
46. Li L, Liu DW, Yan HY, et al. Obesity is an independent risk factor fornon-alcoholic fatty liver disease: evidence from a meta-analysis of 21cohort studies. Obesity Reviews. 2016;17(6):510-519.
47. Bonfrate L, Wang DQ, Garruti G, Portincasa P. Obesity and the riskand prognosis of gallstone disease and pancreatitis. Best Practice & ResClin Gastroenterol. 2014;28(4):623-635.
48. Sever MJ, Kocjan T, Pfeifer M, Kravos NA, Janez A. Short-termcombined treatment with liraglutide and metformin leads to significantweight loss in obese women with polycystic ovary syndrome andprevious poor response to metformin. Eur J Endocrinol. 2014. 170(3):p. 451-459.
49. Escobar-Morreale HF, Botella-Carretero JI, Alvarez-Blasco F, Sancho J,San Millán JL. The polycystic ovary syndrome associated with morbidobesity may resolve after weight loss induced by bariatric surgery. J ClinEndocrinol Metabol. 2005;90(12):6364-6369.
50. Molina-Vega M, Muñoz-Garach A, Damas-Fuentes M, Fernández-García JC, Tinahones FJ. Secondary male hypogonadism: aprevalent but overlooked comorbidity of obesity. Asian J Andrology.2018;20(6):531.
51. Kulie T, Slattengren A, Redmer J, Counts H, Eglash A, Schrager S.Obesity and women’s health: an evidence-based review. J Am BoardFam Med. 2011;24(1):75-85.
52. Stallings SP, Kasdan ML, Soergel TM, Corwin HM. A case-control studyof obesity as a risk factor for carpal tunnel syndrome in a population of600 patients presenting for independent medical examination. J HandSurg. 1997;22(2):211-215.
53. Scott KA, Melhorn SJ, Sakai RR. Effects of chronic social stress onobesity. Current Obesity Reports. 2012;1(1):16-25.
54. Şahin HG. Obezite ve gebelik. Turkiye Klinikleri J Fam Med Special Topics. 2015;6(3):71-73.
55. Basen-Engquist K, Chang M. Obesity and cancer risk: recent review and evidence. Current Oncology Reports. 2011;3(1):71-76.
Article available in :
Volume 1, Issue 1, 2023
Page : 24-29
https://doi.org/10.51271/ICJIM-0005
Article Information
Received : 20 Şub 2023
Accepted : 22 Şub 2023
Published : 25 Şub 2023
Corresponding Author :

Aydın Çifci: Department of Internal Medicine, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkiye

[email protected]
Citation : Çifci A, Öklü K. Obesity: etiology and the problems it causes. Intercont J Int Med 2023; 1(1): 24-29

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