JCCVS

Journal of Cardiology & Cardiovascular Surgery scientific, open-access, double-blind peer-reviewed journal covering a wide spectrum of topics in cardiology and cardiovascular surgery. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

EndNote Style
Index
Original Article
Risk factors related with congenital heart disease: a single center experience
Aims: Many cases of congenital heart disease are multifactorial and result from a combination of genetic predisposition and an as-yet-to-be-determined environmental stimulus. The purpose of the study is to determine the patients who were diagnosed with CHD through echocardiography and to reveal the risk factors that may cause congenital heart anomalies in our center.
Methods: The medical records of pediatric patients applied to our pediatric cardiology clinic between January 2010 –December 2017 were retrospectively reviewed.
Results: 147 cases were diagnosed with CHD. 60 (52.6%) of the cases were female and 54 (47.4) were male. 77 of the 114 patients included in the study were acyanotic (67.5%) and 37 (32.5%) were cyanotic. Seventeen of the acyanotic patients had mixed CHD. The mean maternal gestational age was 28.2±5.78 years. 26 (22.8%) were born preterm. 17 (14.9 %) patients were born with low birth weight (under 2500 g). 8 (7%) patients were LGA (large for gestational age) (birth weight over 4000 g). Average birth weight was 2,98±740,8 gr. Consanguinity was found in the parents of 28 (24.5%) patients. There was a history of CHD in the relatives of 6 (5.2%) patients, siblings of 4 (3.5%) patients, and parents of 5 (4.3%) patients. Chromosomal abnormalities were found in 9 (7.9%) patients.
Conclusion: Our study is a valuable contribution to the existing literature in that it showed that the frequency and distribution of congenital heart diseases have not changed in recent years, and its findings are compatible with the literature findings.


1. Wu W, He J, Shao X. Incidence and mortality trend of congenital heartdisease at the global, regional, and national level, 1990-2017. Medicine(Baltimore). 2020;99(23):e20593
2. Abqari S, Gupta A, Shahab T, et al. Profile and risk factors for congenitalheart defects: A study in a tertiary care hospital. Ann Pediatr Cardiol.2016;9:216-21.
3. Sanders SP, Colan SD, Cordes TM, et al. American Society ofEchocardiography; Society of Pediatric Echocardiography; AmericanCollege of Cardiology Foundation; American Heart Association;American College of Physicians Task Force on Clinical Competence(ACC/AHA/AAP Writing Committee to Develop TrainingRecommendations for Pediatric Cardiology). ACCF/AHA/AAPrecommendations for training in pediatric cardiology. Task force 2:pediatric training guidelines for noninvasive cardiac imaging endorsedby the American Society of Echocardiography and the Society ofPediatric Echocardiography. J Am Coll Cardiol. 2005; 46:1384-8.
4. Zaidi S, Brueckner M. Genetics and Genomics of Congenital HeartDisease. Circ Res. 2017;120:923-40.
5. Namuyonga J, Lubega S, Aliku T, Omagino J, Sable C, Lwabi P. Patternof congenital heart disease among children presenting to the UgandaHeart Institute, Mulago Hospital: a 7-year review. Afr Health Sci.2020;20(2):745-52
6. Warnes CA. Sex differences in congenital heart disease: should awoman be more like a man? Circulation. 2008;118:3-5.
7. Diogenes TCP, Mourato FA, de Lima Filho JL, Mattos SDS. Genderdifferences in the prevalence of congenital heart disease in Down’ssyndrome: a brief meta-analysis. BMC Med Genet. 2017;18:111
8. Verheugt CL, Uiterwaal CS, van der Velde ET, et al. Gender andoutcome in adult congenital heart disease. Circulation. 2008; 118: 26-32.
9. Kadivar M, Kaini A, Kocharian A, et al. Echocardiography andmanagement of sick neonates in the intensive care unit. Congenit HeartDis. 2008;3: 325-9.
10. Dorfman AT, Marino BS, Wernovsky G, et al. Critical heart disease inthe neonate: presentation and outcome at a tertiary care center. PediatrCrit Care Med. 2008;9:193-202.
11. Aydoğdu S.A, Türkmen M, Özkan P. Adnan Menderes Üniversitesiyenidoğan yo-ğun bakım ünitesinde izlenen bebeklerde doğumsal kalphastalığı s ıklığı, J Adnan Menderes Unıversity Medical Faculty. 2008;9: 5-8.
12. Pinto NM, Waitzman N, Nelson R, Minich LL, Krikov S, Botto LD.Early Childhood Inpatient Costs of Critical Congenital Heart Disease. JPediatr. 2018;203:371-379.e7
13. Al Mamun MA , Hussain M, Khan KES. Consanguinity and Risk ofCongenital Heart Defects in Bangladesh. DS (Child) H J 2021; 37: 34-9.
14. Øyen N, Poulsen G, Boyd HA, Wohlfahrt J, Jensen PK, Melbye M.Recurrence of congenital heart defects in families. Circulation.2009;120(4):295-301.
15. Nora JJ, Nora AH. The evolution of specific genetic and environmentalcounseling in congenital heart diseases. Circulation. 1978;57:205-13.
16. Ul Haq F, Jalil F, Hashmi S, et al. Risk factors predisposing to congenitalheart defects. Ann Pediatr Cardiol. 2011;4:117-21.
17. Muntha A, Moges T. Congenital Cardiovascular Anomalies amongCases of Down Syndrome: A Hospital Based Review of Cases inTikurAnbessa Specialized Hospital, Ethiopia. Ethiop J Health Sci.2019;29:165-74.
18. Park SC, Mathews RA, Zuberbuhler JR, Rowe RD, Neches WH, LenoxCC. Down syndrome with congenital heart malformation. Am J DisChild 1977;131:29-33
19. Meberg A, Otterstad JE, Froland G, Sorland S. Children with congenitalheart defects in Vestfold 1982-88. Increase in the incidence resultingfrom improved diagnostics methods. Tidsskr Nor Laegeforen 1990;110:354-7.
20. Marder L, Tulloh R, Pascall E. Cardiac problems in Down syndrome.Paediatr Child Health. 2015;25:23-29.
21. Morris CD. Lessons from epidemiology for the care of women withcongenital heart disease. Prog Pediatr Cardiol 2004;19:p.5-13.
22. Rosenthal GL, Wilson PD, Permutt T, Boughman JA, Ferencz C. Birthweight and cardiovascular malformations: a population-based study.Am J Epidemiol 1991;133:1273-1281.
23. Czeizel AE, Dudás I, Vereczkey A, Bánhidy F. Folate deficiency andfolic acid supplementation: the prevention of neural-tube defects andcongenital heart defects. Nutrients. 2013; 5:4760-4775
Volume 1, Issue 1, 2023
Page : 1-4
_Footer