JCHOR
Journal of Current Hematology & Oncology Research

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Original Article
Evaluation of relationship between hyperuricemia and hyperhomocysteinemia
Abstract
Aims: Hyperuricemia is generally a subclinical disorder. Uric acid takes part in the malignities, obesity-insulin resistance syndrome, and some other cardiovasculer problems. Plasma homocysteine (Hcy) levels are one of the major risk factors of coronary heart disease, one of the major reasons of adult mortality. In this study, it was aimed to determine relationship between hyperuricemia and hyperhomocysteinemia.
Methods: In this prospective research, 32 patients and 32 healthy controls were investigated. The age, sex, height, weight, complaints, medications and arterial blood pressure of the patients were measured and recorded. Moreover, whole blood test, fasting plasma glucose, serum lipids, sedimentation, cobalamin, folate, plasma total Hcy and uric acid levels were determined.
Results: In the patient group 62.51% was male and 37.5% was female. The mean age was 54.69+12.03. In the healthy controls 62.5% was male and 37.5% was female, and the mean age was 51.59+9.57. The difference between the mean ages of both groups was not significant (p>0.05). Uric acid levels were found to be 8.61±0.98 mg/dl in the patient group and 4.09±0.99 mg/dl in the control group, and this difference was significant (p<0.001). Hcy levels were found to be 10.99+1.42 µmol/L in the patient group and 6.67±0.80 gmoI/L in the control group. This difference was also statistically significant (p<0.001)
Conclusion: Hyperuricemia which is generally a subclinical disorder is accepted a coronary risk factor with the presence of other risks. Elevated plasma homocysteine is an independent risk factor for coronary heart disease. There are similar features of the both etiologia. Therefore we recommend to calculate the plasma homocysteine levels in hyperuricemic patients who have the risk of coronary heart disease and to treat the hyperuricemic patients having hyperhomocysteinemia and coronary risk factors.

Keywords : Malignity, uric acid, hyperuricemia, hyperhomocysteinemia

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Article available in :
Volume 1, Issue 2, 2023
Page : 31-35
https://doi.org/10.51271/JCHOR-0008
Article Information
Received : 16 May 2023
Accepted : 20 May 2023
Published : 29 May 2023
Corresponding Author :

Kemalettin Yılmaz: Lokman Hekim Hospital, Gastroenterology Department, Ankara, TURKEY

[email protected]
Citation : Yılmaz K, Özdemir İÇ. Evaluation of relationship between hyperuricemia and hyperhomocysteinemia. J Curr Hematol Oncol Res. 2023;1(2):31-35.

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