JOPIC
Journal of Pulmonology and Intensive Care

The JoPIC is an independent-unbiased, peer-reviewed, and open-access journal of current national and international issues and reviews for original clinical and experimental research, interesting case reports, surgical techniques, differential diagnoses, editorial opinions, letters to the editor, and educational papers in pulmonology, thoracic surgery, occupational diseases, allergology, and intensive care medicine. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Original Article
Determination of bacteriae isolated from catheter culture and antibiotic susceptibility of patients in intensive care unit
Abstract
Aims: Catheter-related bloodstream infections are important causes of mortality and morbidity. In this study, it was aimed to retrospectively determine the distribution of bacterial factors isolated from intra-catheter blood culture and antibiotic susceptibility rates of patients diagnosed with catheter infection in the intensive care unit of Ankara Training and Research Hospital, Cardiovascular Surgery and Neurosurgery.
Methods: In the intensive care unit of Ankara Training and Research Hospital, Cardiovascular Surgery, and Neurosurgery, 79 bacteria isolated from intra-catheter blood cultures of patients diagnosed with catheter infection between January 1, 2021, and December 31, 2022, were included in the study.Antibiotic susceptibility of the factors reproducing in catheter blood culture was obtained from the hospital information system. Antibiotic susceptibilities of bacteria isolated from intra-catheter culture were determined by the disc diffusion method or VITEK-2 automated system.
Results: The frequency of factors reproducing from intra-catheter blood culture of patients hospitalized in the intensive care unit of cardiovascular surgery and neurosurgery were Enterococcus spp., Klebsiella pneumoniae, Staphylococcus epidermidis, and Escherichia. coli retrospectively. Klebsiella pneumoniae isolates from intra-catheter blood cultures were resistant to ceftriaxone 75%, piperacillin-tazobactam 25%, amikacin 6.25%, but not to imipenem and meropenem. Antibiotic resistance rates of Staphylococcus aureus isolates isolated from intra-catheter blood cultures were as follows: 100% with penicillin, no resistance to vancomycin. In Escherichia coliisolate isolated from intra-catheter blood cultures, resistance to ceftriaxone was 6.3%, to piperacillin-tazobactam, 12.5%, to imipenem and meropenem, 16.6%, but not to amikacin. Acinetobacter baumanniiisolates isolated from intra-catheter blood culture showed 100% resistance to ceftriaxone, 100% to piperacillin-tazobactam, 85.7% to imipenem, 83.3% to meropenem, and no resistance to amikacin. In the Stenotrophomonas maltophilia isolatesisolated from intra-catheter blood culture, resistance to ceftriaxone, piperacillin-tazobactam, imipenem and meropenem was 100% and levofloxacin was 25%, while no resistance to trimethoprim/sulfamethoxazole was detected.
Conclusion: Determining the antibiotic susceptibility of bacteria isolated from catheter culture will contribute to the determination of the appropriate treatment option in the empirical treatment of catheter infections in our hospital and contribute to decreasing in mortality and morbidity rates due to catheter infections.

Keywords : Catheter infection, catheter-related bloodstream infection, factors, antibiotic susceptibility

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1. European Committee on Antimicrobial Susceptibity Testing(EUCAST). EUCAST Clinical Breakpoint Table Version 10.0, ValidFrom 2020-01-01. Basel: EUCAST, 2020. http://www.eucast.org/clinical_breakpoints
2. Can B, Aydın S, Öngen B, Gürler N. Kateter örneklerinden izole edilenmikroorganizmalar ve antimikrobik maddelere direnç durumları.ANKEM Derg. 2005;19(1):22-24.
3. Hakyemez İN, Küçükbayrak A, Akdeniz H. Damar içi kateterinfeksiyonlarına güncel yaklaşım. Abant Med J. 2012;1(2):94-98.
4. Beekmann SE, Henderson DK. In: Bennet JE, Dolin R, Blaser MJ,editors. Mandell, Douglas, and Bennett’s Principles and Practice ofInfectious Diseases 9th ed. 2020. p.3560-3575.e7.
5. Walz JM, Memtsoudis SG, Heard SO. Prevention of central venouscatheter bloodstream infections. J Intensive Care Med. 2010;25(3):131-138. doi:10.1177/0885066609358952
6. Mermel LA, Farr BM, Sherertz RJ, et al. Guidelines for the managementof intravascular catheter-related infections. Clin Infect Dis.2001;32(9):1249-1272. doi:10.1086/320001
7. Pitiriga V, Kanellopoulos P, Bakalis I, et al. Central venous catheter-related bloodstream infection and colonization: the impact of insertionsite and distribution of multidrug-resistant pathogens. AntimicrobResist Infect Control. 2020;9(1):189. doi:10.1186/s13756-020-00851-1
8. Pandit P, Sahni AK, Grover N, Dudhat V, Das NK, Biswas AK.Catheter-related blood stream infections: prevalence, risk factorsand antimicrobial resistance pattern. Med J Armed Forces India.2021;77(1):38-45. doi:10.1016/j.mjafi.2019.07.002
9. Bell T, O’Grady NP. Prevention of Central Line-Associated BloodstreamInfections. Infect Dis Clin North Am. 2017;31(3):551-559. doi:10.1016/j.idc.2017.05.007
10. Erdem H, Dizbay M, Karabey S, et al. Withdrawal of Staphylococcusaureus from intensive care units in Turkey. Am J Infect Control.2013;41(11):1053-8. doi: 10.1016/j.ajic.2013.01.041
11. Durdu B, Kritsotakis EI, Lee ACK, et al. Temporal trends and patternsin antimicrobial-resistant Gram-negative bacteria implicated inintensive care unit-acquired infections: A cohort-based surveillancestudy in Istanbul, Turkey. J Glob Antimicrob Resist. 2018;14:190-196.doi:10.1016/j.jgar.2018.04.015
12. Senbayrak Akcay S, Inan A, Cevan S, et al. Gram-negative bacillicausing infections in an intensive care unit of a tertiary care hospital inIstanbul, Turkey. J Infect Dev Ctries. 2014;8(5):597-604. Published 2014May 14. doi:10.3855/jidc.4277
13. Ogutlu A, Guclu E, Karabay O, Utku AC, Tuna N, Yahyaoglu M. Effectsof Carbapenem consumption on the prevalence of Acinetobacterinfection in intensive care unit patients. Ann Clin Microbiol Antimicrob.2014;13:7. doi:10.1186/1476-0711-13-7
14. Ergönül Ö, Aydin M, Azap A, et al. Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictorsof mortality. J Hosp Infect. 2016;94(4):381-385. doi:10.1016/j.jhin.2016.08.012
15. Hatipoğlu ÇA, İpekkan K, Oral B, Önde U, Bulut C, Demiröz AP.Yoğun bakım ünitelerinde gelişen kateter ile ilişkili kan dolaşımıenfeksiyonlarının tanısında kullanılan yöntemlerin değerlendirilmesi.Mikrobiyoloji Bülteni 2011; 45(1):75-85.
16. Oncü S, Ozsüt H, Yildirim A, et al. Central venous catheter relatedinfections: risk factors and the effect of glycopeptide antibiotics. AnnClin Microbiol Antimicrob. 2003;2:3. doi:10.1186/1476-0711-2-3
17. Sarı N. Erol Ç, Hızel K. Yoğun bakım ünitelerinde santral venöz kateterilişkili kan dolaşımı infeksiyonu sıklığı, mikrobiyolojik etkenleri,antibiyotiklere duyarlılıkları ve risk faktörlerinin belirlenmesi. Turk JClin Lab. 2021; 4: 404-408.
18. Aktaş E, Sarı EN, Seremet Keskin A, Pişkin N, Külah C, CömertF. Damar içi kateter ile ilişkili enfeksiyon etkenleri ve antibiyotikduyarlılıkları. Mikrobiyol Bul. 2011;45(1):86-92.
19. Bekçibaşi M, Dayan S, Aslan E, Kortak MZ, Hoşoğlu S. Risk factorsfor central venous catheter-related bloodstream infections. Infez Med.2019;27(3):258-265.
20. Çam B, Ulu kılıç A. Erişkin hematoloji ve kemik iliği transplantasyonu(KİT) ünitelerinde yatan hematolojik maligniteli hastalarda gelişen kandolaşımı enfeksiyonlarının incelenmesi. Kırşehir Ahi Evran ÜniversitesiSağlık Bilimleri Enstitüsü Dergisi. 2020; 1(3): 158-169.
Article available in :
Volume 1, Issue 1, 2023
Page : 9-12
https://doi.org/10.51271/JOPIC-0003
Article Information
Received : 05 Şub 2023
Accepted : 19 Şub 2023
Published : 23 Şub 2023
Corresponding Author :

Salih Cesur: Department of Infectious Diseases and Clinical Microbiology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, TURKEY

[email protected]
Citation : Kaya Kılıç E, Cesur S, AltınDemircan Ş, et al. Determination of bacteriae isolated from catheter culture and antibiotic susceptibility of patients in intensive care unit. J Pulmonol Intens Care 2023; 1(1): 9-12

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