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Kastamonu Medical Journal

Kastamonu Medical Journal regularly publishes internationally qualified issues in the field of Medicine in the light of up-to-date information.

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Original Article
A predictive marker for target organ damage in primary hypertension: serum uric acid levels
Abstract
Aims: This study aims to investigate the relationship between serum uric acid levels, the left ventricular mass index (LVMI), and carotid intima media thickness (CIMT) in primary hypertension patients.
Methods: A total of 139 primary hypertension patients, including 45 (32.4%) men and 94 (67.6%) women were involved in the study. The laboratory and clinical demographic findings, as well as the LVMI and CIMT levels of the patients were collected from patient files.
Results: 37% of the study population were found to have hyperuricemia. LVMI (99.75±13.4 vs 86.17±17.6; p=0.010) and CIMT (0.88±0.26 vs 0.75±0.17; p=0.023) levels were found to be higher in the hyperuricemia versus the non-hyperuricemia group. According to the correlation analysis, there was a positive correlation between uric acid and LVMI (r=0.282, p=0.032) and CIMT (r=0.285, p=0.002) levels. Robust regression analysis showed that uric acid was an independent risk factor for both the LVMI (ß±SE: 1.615±1.03, p<0.05) and CIMT (ß±SE: 0.251±0.09, p<0.05).
Conclusion: We found serum uric acid levels to be closely related with the target organ damage associated with primary hypertension, and even related with target organ damage independent from blood pressure.

Keywords : Primary hypertension, hyperuricemia, carotid intima media thickness, left ventricular mass index

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Article available in :
Volume 1, Issue 2, 2021
Page : 31-36
https://doi.org/10.51271/KMJ-0008
Article Information
Received : 22 Mar 2021
Accepted : 28 May 2021
Published : 29 Ara 2022
Corresponding Author :

Fatma Akyel: Kastamonu University, Faculty of Medicine, Department of Internal Medicine, Kastamonu, Turkey

[email protected]
Citation : Akyel F, Yılmaz N. A predictive marker for target organ damage in primary hypertension: serum uric acid levels. Kastamonu Med J. 2021;1(2): 31-36.

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