KASMEJ

Kastamonu Medical Journal regularly publishes internationally qualified issues in the field of Medicine in the light of up-to-date information.

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Original Article
Assessment of Micro-R/Macro-R values and other hemogram parameters for the diagnosis of early neonatal sepsis
Aim: Neonatal sepsis is a systemic condition that results in hemodynamic and clinical findings. We aimed to determine the role of hemogram parameters in the diagnosis of early neonatal sepsis. Material and Method: This retrospective study was conducted with 126 neonates hospitalized in Kastamonu Training and Research Hospital Neonatal Intensive Care Unit between March 2018 to March 2022. There were 65 term neonates diagnosed with early neonatal sepsis in the patient group. In the control group, there were 61 term neonates who underwent hemogram within the first 72 hours (postnatal period) due to physiological jaundice and did not receive any antibiotic treatment. The assessment was made by comparing the hemogram parameters of these groups. Results: The Macro-R value, white blood cell count, absolute neutrophil count, monocyte count, immature erythrocyte count and percentage, immature granulocyte count and percentage and neutrophil-lymphocyte ratio were found to be significantly higher in the patient group than in the control group (p<0.05). Macro R, white blood cell count, absolute neutrophil count, immature erythrocyte count and percentage, immature granulocyte count and neutrophil/lymphocyte ratio had high sensitivity and specificity for the diagnosis of early neonatal sepsis. Conclusion: We think that these simple and easily accessible parameters have potential value in the diagnosis of ENS if they are used together with the clinical symptoms of ENS.


1. Odabaşı &Ouml;.İ, B&uuml;lb&uuml;l A. Neonatal Sepsis. Med Bull Sisli Etfal Hosp 2020; 54:142-58.
2. Liu L, Johnson HL, Cousens S, et al; Child Health Epidemiology ReferenceGroup of WHO and UNICEF. Global, regional, and national causes of childmortality: an updated systematic analysis for 2010 with time trends since2000. Lancet 2012; 379: 2151-61.
3. Oza S, Lawn JE, Hogan DR, Mathers C, Cousens SN. Neonatal cause-of-death estimates for the early and late neonatal periods for 194 countries:2000-2013. Bull World Health Organ 2015; 93: 19-28.
4. Centers for Disease Control and Prevention (CDC). Perinatal group Bstreptococcal disease after universal screening recommendations--United States, 2003-2005. MMWR Morb Mortal Wkly Rep 2007; 56: 701-5.
5. Centers for Disease Control and Prevention (CDC). Trends in perinatalgroup B streptococcal disease - United States, 2000- 2006. MMWR MorbMortal Wkly Rep 2009; 58: 109-12.
6. Satar M, Arısoy AE, &Ccedil;elik İH. T&uuml;rk Neonatoloji Derneği YenidoğanEnfeksiyonları Tanı ve Tedavi Rehberi 2018. Available at: http: //www.neonatology.org.tr/wp-content/uploads/2017/12/yenidogan_enfeksiyonlari_tan%C4%B1_ve_tedavi_rehberi_2018.pdf. Accessed Apr 9,2020.
7. Raimondi F, Ferrara T, Maffucci R, et al. Neonatal sepsis: a difficultdiagnostic challenge. Clin Biochem 2011; 44: 463-4.
8. Waseem RI, Khan M, Izhar TS, Qureshi AW. Neonatal sepsis. ProfessionalMed J 2005; 12: 451-6. Bulletin of the World Health Organization 2009; 87:130-8.
9. Clark R, Powers R, White R, et al. Prevention and treatment of nosocomialsepsis in the NICU. J Perinatol 2004; 24: 446-53.
10. Yorulmaz A, Y&uuml;cel M, Sert S. Diagnostic value of haematological parametersin neonatal sepsis cases. Ortadogu Med J 2018; 10: 252-62.
11. Yalınbaş E.E, Bilgin H. Thrombocyte Parameters And Neutrophıl/Lymphocyte Ratio İn The Diagnosis Of Neonatal Sepsıs. Kocatepe Med J2020; 21: 104-9.
12. Smith B.P, Hornik C.P, Benjamin D.K, et al. Use of the Complete Blood CellCount in Early-Onset Neonatal Sepsis. Pediatr Infect Dis J 2012; 31: 799-802.
13. Saboohi E, Saeed F, Khan R.N, Khan M.A. Immature to total neutrophilratio as an early indicator of early neonatal sepsis. Pak J Med Sci 2019; 35:241-6.
14. Philip AG, Hewitt JR. Early diagnosis of neonatal sepsis. Pediatrics. 1980;65: 1036-41.
15. Iddles C, Taylor J, Cole R, et al. Evaluation of immature granulocyte countin the diagnosis of sepsis using the Sysmex XE-2100 analyser. Sysmex J Int2007; 17: 20-9.
16. G&uuml;ng&ouml;r A, G&ouml;ktuğ A, Tekeli A, et al. Evaluation of the accuracy of immaturegranulocyte percentage in predicting pediatric serious bacterial infection.Int J Lab Hematol 2021; 43: 632-7
17. Boskabadi H, Zakerihamidi M, Sadeghian MH, et al. Nucleated red bloodcells count as a prognostic biomarker in predicting the complications ofasphyxia in neonates. J Matern Fetal Neonatal Med 2017; 30: 2551e6.
18. Sarah U.M, Kaitlyn B, Henry A.F, Kristen T.L. Association of nucleated redblood cell count with mortality among neonatal intensive care unit patients.Pediatrics and Neonatology 2020; 61: 592-7
19. Eloisa U, Luis B, Jesus F.E. Potential utility of the new sysmex XE 5000red blood cell extended parameters in the study of the disorders of ironmetabolism. Clin Chem Lab Med 2009; 47: 1411-6.
20. Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils inthe activation and regulation of innate and adaptive immunity. Nat RevImmunol 2011; 11: 519-31.
21. Zhang HB, Chen J, Lan QF, et al. Diagnostic values of red cell distributionwidth, platelet distribution width and neutrophil lymphocyte count ratio forsepsis. Experimental Therapeutic Med 2016; 12: 2215-9.
22. Alkan Ozdemir S, Arun Ozer E, Ilhan O, Sutcuoglu S. Can neutrophil tolymphocyte ratio predict late-onset sepsis in preterm infants? J Clin LabAnal 2018; 32: e22338
23. Can E, Hamilcikan Ş, Can C. The Value of Neutrophıl to Lymphocyte Ratioand Platelet to Lymphocyte Ratio For Detecting Early-onset NeonatalSepsis. J Pediatr Hematol Oncol 2018; 40: 229-32.
Volume 2, Issue 4, 2022
Page : 104-107
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