Published November 3, 2019 | Version v1
Dataset Open

Individual datasets investigating combined toxicity of binary mixtures in bees from laboratory tests

  • 1. Institute for Risk Assessment Sciences (IRAS), Utrecht University, Istituto di Ricerche Farmacologiche Mario Negri IRCCS
  • 2. Centre for Ecology and Hydrology
  • 3. Arpae Emilia Romagna, Bologna, Italy
  • 4. INERIS, Paris, France
  • 5. CERTARA, Paris, France
  • 6. Istituto di Ricerche Farmacologiche Mario Negri IRCCS
  • 7. International Prevention Research Institute, Lyon, France
  • 8. European Food Safety Authority

Description

This excel file (DOI: https://doi.org/10.5281/zenodo.3383713) provides the individual datasets on binary mixture toxicity (mortality) in bees classified according to route and exposure patterns (i.e. oral, contact, acute and chronic) and mortality endpoints (e.g.LD50, LC50) for the honeybee (Apis mellifera) and wild bee species (Osmia bicornis, Bombus terrestris). 218 individual binary mixtures were collected and included in the statistical analyses with the majority of toxicological endpoints reported as lethal doses or concentrations (e.g. LD50, LC50,) for pesticides or pesticides and veterinary drugs combinations with 133, 44 and 41 mixtures reporting acute contact toxicity (i.e. topical application), chronic oral toxicity and acute oral toxicity, respectively. Combined toxicity data for binary mixtures were available as dose response data in honeybees for acute contact toxicity (n=92) and acute oral toxicity.

The full data collection and analysis of binary mixtures are described in Carnesecchi et al., 2019 (DOI: 10.1016/j.envint.2019.105256)

Notes

EU; XLSX; jean-lou.dorne@efsa.europa.eu

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Additional details

References

  • Carnesecchi, E., Svendsen, C., Lasagni, S., Grech, A., Quignot, N., Amzal, B., Toma, C., Tosi, S., Rortais, A., Cortinas-Abrahantes, J., Capri, E., Kramer, N., Benfenati, E., Spurgeon, D., Guillot, G., Dorne, J.L.C.M., 2019. Investigating combined toxicity of binary mixtures in bees: Meta-analysis of laboratory tests, modelling, mechanistic basis and implications for risk assessment. Environ. Int. 133. https://doi.org/10.1016/j.envint.2019.105256
  • Carnesecchi E., Toropova A. P., Toropov A. A., Benfenati E., Dorne JL. (2020). Predicting acute contact toxicity of organic binary mixtures in honey bees (A. mellifera) through innovative QSAR models. Science of the Total Environment. 704, 135302.