Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 6, 03 August 2023
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Lysosomal proton pump: its role in SARS-CoV-2’s egress and future therapeutic application
* Author to whom correspondence should be addressed.
Abstract
The coronavirus SARS-CoV-2 is currently spreading throughout the world. The severity of the situation has increased efforts to create efficient prevention and treatment strategies. SARS-CoV-2 has been the subject of numerous experiments, and as a result, scientists now understand it better. Usually, the virus exits the cell through exocytosis. However, SARS-CoV-2 utilizes deacidified lysosomes as a means to egress from the infected cell.This proposal shows a deep understanding of lysosomal viral secretion and elaborates on the impact of the lysosomal proton pump, which functions to regulate the pH value of the endo-lysosomal environment, on lysosome functioning. Experiment are proposed to test the ability of a lysosomal proton pump inhibitor to impede the egress of the SARS-CoV-2 virus and analyze its potential application in a therapeutic target.
Keywords
SARS-CoV-2. deacidified lysosomes, lysosomal viral secretion, lysosomal proton pump
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
- ISBN (Print)
- 978-1-915371-65-2
- ISBN (Online)
- 978-1-915371-66-9
- Published Date
- 03 August 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/6/20230287
- Copyright
- 03 August 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited