Case Control Study Open Access
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Dec 22, 2015; 5(4): 404-411
Published online Dec 22, 2015. doi: 10.5498/wjp.v5.i4.404
Comprehensive neurocognitive assessment of patients with anorexia nervosa
Andrea Phillipou, David Jonathan Castle, Department of Psychiatry, the University of Melbourne, Melbourne 3010, Australia
Andrea Phillipou, Larry Allen Abel, Department of Optometry and Vision Sciences, the University of Melbourne, Melbourne 3010, Australia
Andrea Phillipou, Department of Mental Health, the Austin Hospital, Melbourne 3084, Australia
Caroline Gurvich, Susan Lee Rossell, Monash Alfred Psychiatry Research Centre, Melbourne 3004, Australia
David Jonathan Castle, Susan Lee Rossell, Department of Psychiatry, St Vincent’s Hospital, Melbourne 3065, Australia
David Jonathan Castle, Faculty of Health Sciences, Australian Catholic University, Melbourne 3065, Australia
Susan Lee Rossell, Brain and Psychological Sciences Research Centre, Swinburne University of Technology, Melbourne 3122, Australia
Author contributions: Phillipou A, Gurvich C, Castle DJ, Abel LA and Rossell SL designed the research and wrote the paper; Phillipou A performed the research.
Supported by The Jack Brockhoff Foundation (3410); the Dick and Pip Smith Foundation; Australian Postgraduate Award; and the David Hay Memorial Fund Award.
Institutional review board statement: The study was granted independent ethics approval by the Human Research Ethics committees at St Vincent’s Hospital [Human Research Ethics Committee A (HREC-A)] (057/12), Austin Health [Non Drug Study Advisory Committee (NDSAC)] (H2012/04646) and The Melbourne Clinic [The Melbourne Clinic Research Ethics Committee (TMC REC)] (235). In addition, the study received expedited ethics approval from Swinburne’s Human Research Ethics Committee (SUHREC) (2012/277) and was registered with The University of Melbourne Health Sciences Human Ethics Sub-Committee (HESC) (1239068), on the basis of the prior St Vincent’s Hospital review.
Informed consent statement: All participants gave written informed consent prior to study inclusion.
Conflict-of-interest statement: Professor Castle reports grants and personal fees from Eli Lilly, grants and personal fees from Janssen-Cilag, Roche, Allergen, Bristol-Myer Squibb, Pfizer, Lundbeck, AstraZeneca and Hospira during the conduct of the study, outside the submitted work; and personal fees from Eli Lilly, Bristol-Myer Squibb, Lundbeck, Janssen-Cilag, Pfizer, Organon, Sanofi-Aventis, Wyeth, Hospira and Servier, outside the submitted work. Associate Professor Abel reports personal fees from Actelion Pharmaceuticals, Switzerland, outside the submitted work. Dr. Phillipou, Professor Rossell and Dr. Gurvich report no conflicts of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the lead author at ap@unimelb.edu.au. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: David Jonathan Castle, MD, Professor of Psychiatry, Department of Psychiatry, St Vincent’s Hospital, Level 2, 46 Nicholson St, Fitzroy, Melbourne 3065, Australia. david.castle@svha.org.au
Telephone: +61-3-92314751 Fax: +61-3-92314802
Received: June 24, 2015
Peer-review started: June 29, 2015
First decision: August 26, 2015
Revised: August 31, 2015
Accepted: October 1, 2015
Article in press: October 8, 2015
Published online: December 22, 2015

Abstract

AIM: To utilise a comprehensive cognitive battery to gain a better understanding of cognitive performance in anorexia nervosa (AN).

METHODS: Twenty-six individuals with AN and 27 healthy control participants matched for age, gender and premorbid intelligence, participated in the study. A standard cognitive battery, the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery, was used to investigate performance on seven cognitive domains with the use of 10 different tasks: speed of processing [Brief Assessment Of Cognition In Schizophrenia: Symbol Coding, Category Fluency: Animal Naming (Fluency) and Trail Making Test: Part A], attention/vigilance [Continuous Performance Test - Identical Pairs (CPT-IP)], working memory [Wechsler Memory Scale (WMS®-III): Spatial Span, and Letter-Number Span (LNS)], verbal learning [Hopkins Verbal Learning Test - Revised], visual learning [Brief Visuospatial Memory Test - Revised], reasoning and problem solving [Neuropsychological Assessment Battery: Mazes], and social cognition [Mayer-Salovey-Caruso Emotional Intelligence Test: Managing Emotions]. Statistical analyses involved the use of multivariate and univariate analyses of variance.

RESULTS: Analyses conducted on the cognitive domain scores revealed no overall significant difference between groups nor any interaction between group and domain score [F(1,45) = 0.73, P = 0.649]. Analyses conducted on each of the specific tasks within the cognitive domains revealed significantly slower reaction times for false alarm responses on the CPT-IP task in AN [F(1,51) = 12.80, P < 0.01, Cohen’s d = 0.982] and a trend towards poorer performance in AN on the backward component of the WMS®-III Spatial Span task [F(1,51) = 5.88, P = 0.02, Cohen’s d = -0.665]. The finding of slower reaction times of false alarm responses is, however, limited due to the small number of false alarm responses for either group.

CONCLUSION: The findings are discussed in terms of poorer capacity to manipulate and process visuospatial material in AN.

Key Words: Cognition, Eating disorder, Body image, Spatial processing, Short-term memory

Core tip: The findings of this study suggest that individuals with anorexia nervosa (AN) have largely intact cognitive performance, which notably differs to the cognitive profile of other psychiatric illnesses, such as schizophrenia, bipolar disorder and major depressive disorder, which are all associated with significant cognitive deficits. However, a trend for AN participants to perform poorer on the backward component of a spatial span task was revealed. This suggests a poorer capacity to process and manipulate visuospatial information in AN, which may be related to the distortions of body image experienced by these individuals.



INTRODUCTION

Anorexia nervosa (AN) is a serious psychiatric condition with a mortality rate among the highest of any mental illness[1,2]. Yet, the factors involved in the genesis and maintenance of the illness remain unclear. A common feature of AN is perfectionism, which has been identified as a significant risk factor for the illness, and is a feature found to persist following long-term recovery[3,4]. Thus, cognitive assessments reported in the AN literature often focus on tasks related to perfectionism and rigid thinking patterns, such as cognitive set shifting tasks[5]. Individuals with AN have been found to perform significantly more poorly than healthy individuals during tasks of cognitive set shifting such as the Wisconsin Card Sort Test and certain target detection tasks, displaying stereotyped behaviours with rigid approaches to changing rules[6-8]. However, unlike other psychiatric illnesses, there is a paucity of research employing more comprehensive assessments of cognitive profile in AN.

Studies of cognition in AN have tended to use a range of cognitive assessments rather than utilising a standard cognitive battery; they have consequently reported conflicting findings[9-18]. Therefore, the use of a standard neurocognitive battery, such as the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB)[19], would be advantageous and would also allow for direct comparisons to be drawn between AN and other clinical populations. The MCCB was originally designed to assess cognitive domains most relevant to schizophrenia but has since been applied to assess cognitive impairments in other psychiatric illnesses, including bipolar disorder[20], posttraumatic stress disorder[21] and major depressive disorder[22]. With the use of 10 different tasks, the MCCB assesses the following 7 cognitive domains: speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition.

Although cognitive batteries have been compiled in past research to assess cognition in AN[12,13], a standardised cognitive battery has rarely been used[23]. Furthermore, although each of the cognitive domains in the MCCB has been investigated in past research in AN, the findings are largely inconsistent. Under the speed of processing domain, intact fluency and symbol coding performance has typically been found[15,24]. Poorer performance on trail making tasks on the other hand have been reported by some researchers[25], but not by others[8]. In relation to the attention/vigilance domain, performance on a continuous performance task has not been found to differ from healthy individuals[26], though performance on a similar task requiring rapid visual information processing has been found to result in poorer performance in AN patients[27]. Performance on tasks assessing verbal and visuospatial working memory, on the other hand, have also been found to not differ from healthy individuals by some investigators[10,27], whilst others have reported poorer visuospatial working memory in AN[28]. In relation to visual learning, performance has typically been found to be intact in AN[9,29]. Furthermore, although performance on reasoning and problem solving tasks such as mazes has also been found to be largely intact in AN[23], other tasks assessing this domain such as object assembly and block design, have been found to result in poorer performance in AN[11,28]. Finally, studies assessing social cognition in AN also show inconsistent findings, with some reporting poorer performance[30] and others failing to find a significant difference from healthy individuals[31].

Therefore, the aim of this study was to utilise a comprehensive battery of tasks to investigate cognitive performance in AN. We hypothesised that individuals with AN would show poorer performance on tasks assessing each of the cognitive domains, except the tasks assessing speed of processing and visual learning, where the literature has reported intact performance to date. We further completed exploratory analyses of performance of each of the tasks in AN given that the MCCB was originally designed to examine cognitive profile in people with schizophrenia, who are reported to show substantial cognitive problems. Individuals with AN are not expected to show such extreme deficits, and thus may only show impairment at the individual task level rather than at the level of domains overall. As cognitive performance is significantly affected by malnutrition[32] and this is a likely factor in the inconsistent findings to date in AN, we sought to investigate AN participants who were at a uniform phase of their illness trajectory [medically stable but below the healthy body mass index (BMI) range].

MATERIALS AND METHODS

This study was approved by the Human Research Ethics Departments at the University of Melbourne, Swinburne University of Technology, the Melbourne Clinic, the Austin Hospital and St Vincent’s Hospital; all in Melbourne, Australia. Informed written consent was obtained from all participants. The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.

Participants

Participants were 26 right-handed females with AN and 27 healthy controls (HC). Groups were matched for age and premorbid intelligence quotient (IQ). HCs were recruited through public advertisements, whereas AN participants were recruited through public advertisements; the Body Image and Eating Disorders Treatment and Recovery Service at the Austin and St Vincent’s Hospitals; and The Melbourne Clinic; all in Melbourne, Australia. All patients were required to be medically stable (i.e., not requiring medical attention due to their physical state) prior to inclusion in the study.

All participants were English speaking and had no history of significant brain injury or neurological condition. Controls were required to have no history of an eating disorder or other mental illness; they were also required to not be taking any medications apart from hormonal contraceptives (11 HC participants were taking medications). AN participants were instructed to continue with their normal medications, which were: selective serotonin reuptake inhibitors (11), atypical antipsychotics (12), benzodiazepines (6), serotonin-noradrenaline reuptake inhibitors (SNRIs) (3), hormonal contraceptives (3), melatonergic antidepressants (3), noradrenergic and specific serotonergic antidepressant (1) and cyclopyrrolones (1).

The Mini International Neuropsychiatric Interview, 5.0.0[33] was used to screen all participants for major Axis I psychiatric disorders according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). It was also used to confirm diagnoses of AN, with the exception of the amenorrhea criterion which is no longer included in the current DSM-5. AN was required to be the primary diagnosis of the AN group. AN participants with comorbid psychiatric conditions, other than psychotic conditions, were not excluded as this would not have represented a typical AN sample.

Premorbid intelligence was estimated using the Wechsler Test of Adult Reading[34]. Eating disorder symptomatology was investigated with the Eating Disorders Examination Questionnaire[35] (Table 1).

Table 1 Clinical characteristics.
ANHCFPCohen’s d
M (SD)M (SD)
Age22.81 (6.67)22.46 (3.16)0.060.810.07
WTAR104.77 (8.11)106.19 (7.11)0.460.500.19
BMI16.63 (1.19)22.60 (3.53)67.08< 0.012.27
Illness duration6.42 (7.43)----
Age of illness onset16.04 (3.40)----
EDE-Q restraint3.93 (1.42)0.58 (0.63)116.84< 0.013.05
EDE-Q eating concern3.78 (1.24)0.25 (0.31)188.56< 0.013.91
EDE-Q shape concern5.01 (0.90)1.17 (0.84)236.44< 0.014.41
EDE-Q weight concern4.50 (1.41)0.66 (0.82)136.11< 0.013.33
EDE-Q global score4.30 (1.12)0.67 (0.54)211.44< 0.014.13
Cognitive battery

With the use of 10 different tasks, the MCCB assesses 7 cognitive domains. Scores on each task are entered into the MATRICS scoring program which produces cognitive domain scores.

Speed of processing: Speed of processing is assessed with three different tasks. The Brief Assessment of Cognition in Schizophrenia: Symbol Coding task requires participants to use a key to correctly match and report as many digits that correspond to nonsense symbols as they can within 90 s; the number of correctly matched symbols constitutes the score. The Category Fluency: Animal Naming (Fluency) task requires participants to orally report as many animals as they can in 60 s, which constitutes the task score. The Trail Making Test: Part A task requires participants to draw a line connecting consecutive numbers from 1 to 25 irregularly placed on a sheet of paper as quickly as possible. The score is equivalent to the amount of time in seconds required to complete the task.

Attention/vigilance: Attention/vigilance is assessed with the Continuous Performance Test - Identical Pairs (CPT-IP). In this task, trials of 2-, 3- and 4-digit numbers are flashed briefly on a computer monitor and participants are required to click the mouse when the same number appears consecutively. The total number of possible hits is 90, the total number of possible false alarms is also 90, and total number of possible random responses is 270.

Working memory: Non-verbal working memory is assessed with the Wechsler Memory Scale (WMS®-III): Spatial Span, a visual analogue of the digit span task. The Spatial Span task involves the administrator tapping a series of cubes in a specified sequence and participants are required to reproduce this sequence in the same order (“forward” component). Following the “forward” component, the “backward” component is administered in the same manner except participants are now required to reproduce the sequence in the reverse order. The number of correct sequences reproduced constitutes the task score.

The Letter-Number Span (LNS) task is a task of verbal working memory which requires the mental reordering of orally presented lists of intermixed letters and numbers. In this task, a list of letters and numbers is read out to respondents. The respondent is required to mentally reorder the sequence and verbally report the sequence beginning with the numbers from smallest to largest, followed by the letters in alphabetical order. The number of correct reordered sequences constitutes the score on the task.

Verbal learning: Verbal learning is tested with the Hopkins Verbal Learning Test - Revised. A list of 12 words from 3 semantic categories (four-legged animals, precious stones and human dwellings) is read out and respondents are required to report as many words as they can remember, in any order. The task comprises 3 trials, enabling a maximum score of 36. Following a period of 20-25 min, participants are asked to recall as many words as they can (trial 4). A retention score is also calculated by dividing the score for trial 4 by the higher score of trials 2 and 3, multiplied by 100. A longer list of 24 words is also read out to participants containing the original 12 words, as well as 6 semantically-related words and 6 semantically-unrelated words. A delayed recognition score is calculated by the total number of true positives minus the total number of false positives.

Visual learning: Visual learning is assessed with the Brief Visuospatial Memory Test - Revised which requires participants to reproduce 6 geometric figures following a 10 s presentation. The task comprises 3 trials, with one point each awarded for accuracy and correct placement of the figure, resulting in a maximum score of 36.

Reasoning and problem solving: Reasoning and problem solving is examined with the Neuropsychological Assessment Battery: Mazes task. In this task, a set of 7 mazes of increasing difficult is administered to participants. The score received for each maze is determined by the speed in which it is completed. A maximum score of 26 is achievable.

Social cognition: Social cognition is assessed with the Mayer-Salovey-Caruso Emotional Intelligence Test: Managing Emotions. The tasks involve the respondent rating the effectiveness of alternative actions or responses in achieving a certain result in situations where an individual must regulate their emotions. Lower scores indicate poorer performance.

Statistical analysis

Following normality checking and the removal of outliers, a multivariate analysis of variance (MANOVA) was first conducted on the seven cognitive domain scores across groups. Secondly, one way analysis of variance was used on each of the task variables to compare group performance, with alpha set at 0.01 to account for multiple comparisons. Statistical review of the study was performed by a biomedical statistician.

RESULTS

A MANOVA conducted on the cognitive domain scores revealed no overall significant difference between groups nor any interaction between group and domain score [F(1,45) = 0.73, P = 0.649] (Table 2). Analyses conducted on each of the specific tasks within the cognitive domains revealed significantly slower reaction times for false alarm responses on the CPT-IP task in AN [F(1,51) = 12.80, P < 0.01, Cohen’s d = 0.982] and a trend towards poorer performance in AN on the backward component of the WMS®-III Spatial Span task [F(1,51) = 5.88, P = 0.02, Cohen’s d = -0.665] (Table 3). The finding of slower reaction times of false alarm responses is, however, limited due to the small number of false alarm responses for either group.

Table 2 Cognitive domain scores.
ANHCFPCohen’s d
M (SD)M (SD)
Speed of processing57.42 (9.75)59.85 (7.80)1.010.320.28
Attention/vigilance43.42 (8.08)46.85 (8.47)2.270.140.41
Working memory56.12 (9.68)58.56 (9.33)0.870.360.26
Verbal learning53.38 (10.33)50.33 (8.19)1.420.240.33
Visual learning54.85 (6.25)56.59 (9.77)0.600.440.21
Reasoning and problem solving55.15 (8.29)58.11 (7.11)1.950.170.38
Social cognition49.42 (6.93)48.07 (10.86)0.290.590.15
Overall composite54.31 (7.97)56.19 (7.03)0.830.370.25
Table 3 Specific task scores.
ANHCFPCohen’s d
M (SD)M (SD)
Speed of processing
BACS SC63.23 (9.80)68.11 (9.19)3.500.070.51
Fluency28.19 (6.43)27.19 (5.54)0.370.540.17
TMT-A23.62 (57.50)21.30 (4.83)2.540.120.44
Attention/vigilance
CPT-IP
Hits proportion0.82 (0.10)0.86 (0.09)1.650.210.42
Hits reaction time550.25 (60.43)533.05 (51.08)1.260.270.31
False alarms proportion0.11 (0.05)0.09 (0.06)1.040.310.36
False alarms reaction time508.08 (147.39)369.98 (133.55)12.80< 0.010.98
Random responses proportion0.01 (0.01)0.01 (0.01)1.960.170.00
DPRIME score2.55 (0.54)2.78 (0.56)2.370.130.42
Working memory
WMS®-III
Forward score9.65 (2.30)10.3 (1.88)1.250.270.31
Backward score9.12 (1.80)10.3 (1.75)5.880.020.67
Total score18.77 (3.54)20.59 (2.94)4.180.050.56
LNS17.38 (2.82)16.74 (2.97)0.660.420.22
Verbal learning
HVLT-R™
Total recall29.38 (4.01)28.07 (3.82)1.480.230.34
Delayed recall13.42 (17.74)9.96 (1.63)1.020.320.23
Delayed retention92.80 (14.13)91.98 (14.59)0.040.840.06
Delayed recognition11.04 (0.96)10.93 (1.33)0.120.730.10
Visual learning
BVMT-R™28.62 (3.98)29.78 (6.23)0.650.420.22
Reasoning and problem solving
NAB®: Mazes22.46 (3.43)23.70 (2.63)2.200.140.41
Social cognition
MSCEIT™: Managing emotions96.98 (5.92)95.41 (9.57)0.510.480.20
DISCUSSION

Overall, the results from this study suggest intact cognitive performance in AN on the majority of the measures studied, despite significantly low BMIs and the potential long- and short-term effects of starvation. The only cognitive measure which showed a trend toward impairment in the AN group was visuospatial working memory. Poorer performance in AN was specifically found during the backward component of the task and not the forward component of the task, or the task overall. A study by Fowler et al[27] also reported intact overall spatial span performance in AN, but did not report whether AN and healthy individuals differed in the forward or backward components of the task. The forward component is thought to represent the capacity of the visuospatial sketchpad, whereas the backward component of this task is thought to represent a measure of executive function as it requires additional manipulation within temporary storage[36], suggesting that individuals with AN have specific working memory difficulties when the cognitive demand is high. This deficit appears to be specific to visuospatial working memory as LNS performance was intact in this cohort. Working memory deficits specific to visuospatial working memory have also been reported by Kemps et al[28], who found AN participants were poorer at recalling object locations, but did not differ in the recall of object names compared to healthy individuals. This finding is also in keeping with several studies reporting impairments in immediate recall on visuospatial memory tasks such as the Rey Complex Figure Test[37]. Poorer capacity to manipulate and process visuospatial material may also be related to the specific visuospatial processing deficits experienced in AN, in which patients overestimate the size of their own body[38]; though, this relationship would require specific investigation.

Contrary to expectations, individuals with AN did not differ from healthy individuals in performance on any other task. Though the AN group were found to make false alarm responses of longer reaction time than the control group, this finding is limited due to the small number of false alarm responses for either group, thereby not allowing accurate statistical analyses to be undertaken. The existing research utilising the same or similar tasks is particularly inconsistent with many studies reporting no cognitive deficits, while others report significantly poorer cognitive performance in AN. The inconsistency in findings may be largely related to differences in methodology, particularly the participants examined. Malnutrition certainly effects cognitive function as reported in studies of induced starvation[32]. Studies in AN patients often recruit individuals currently undergoing inpatient treatment as they are often easily accessible to researchers. The primary role of most inpatient treatment services is medical stabilisation. Therefore, patients admitted to such services are typically very physically unwell. The majority of patients in this study were outpatients at the time of testing. Furthermore, the few inpatients included were required to be medically stable. Despite all patients recruited for this study being medically stable, their BMIs were significantly below normal and their eating disorder symptomatology significantly high, suggesting that they were in an acute phase of the illness but were physically well enough to function. Therefore, the sample recruited is a significant strength of this study, especially as they were age, gender and IQ matched to the HC cohort, resulting in a homogenous sample which is often not achieved in research in AN.

The study is, however, not without its limitations. The MCCB is a standard cognitive battery originally compiled to assess the areas of cognition most relevant to schizophrenia and related disorders. Therefore, cognitions often associated with AN, such as cognitive set shifting[8,39,40], were not investigated. As the aim of the study was to investigate general cognition in AN, and the existing cognitive battery was already lengthy, an additional cognitive set shifting task was not considered feasible. Future research in AN would benefit from including set shifting tasks. Although the MCCB provides a comprehensive profile of basic cognitive tasks, a battery also including tasks related to the specific cognitive traits commonly associated with AN, and tasks allowing more detailed exploration of executive function would be beneficial in future research. Furthermore, the modest sample size may have contributed to the lack of significant differences between groups. Thus, further research utilising the same measures in a larger sample may reveal statistically significant group differences, rather than the trends reported in the current study. A further potential limitation is that the majority of patients were on medication at the time of testing, which may have influenced the findings.

The findings of this study suggest a cognitive profile in AN different to that of other psychiatric illnesses, such as schizophrenia, bipolar disorder and major depressive disorder, which are all associated with significant cognitive deficits on the MCCB[20,22,41]. Similar findings to the current study have, however, been reported in obsessive compulsive disorder (OCD). Intact performance on a range of cognitive tasks have been reported in OCD. Similarly to the current study, poorer performance on tasks of spatial working memory[42], but not specifically spatial span[43], have been reported in OCD patients. Similarly, poor visuospatial working memory has also been reported in body dysmorphic disorder (BDD), another psychiatric illness within the OCD-spectrum with prominent body image disturbance[44,45]. Though, unlike the current findings, poorer performance on tasks of verbal working memory and executive function have also been reported in BDD[45,46]. Unlike the current study, however, the spatial span task components in these studies were not separated to better investigate visuospatial working memory. The deficits in visuospatial working memory and otherwise intact cognitive performance in OCD illustrates the overlap in clinical presentation that is often reported in AN, and may provide support for the long-proposed hypothesis that AN and OCD share overlapping psychopathology[47].

Overall, visuospatial working memory was the only cognitive measure that groups were found to differ on in this study, and this may be related to AN patients’ difficulties in evaluating their own bodies. As cognitive functioning in general appears to remain largely unaltered in AN, it may suggest that the limited cognitive deficits observed may arise from quite restricted brain regions which may also be involved in the psychopathology of AN.

ACKNOWLEDGMENTS

The authors would like to thank Charlotte Keating for administering the clinical interview. The authors would also like to thank Chia Huang, Richard Newton, Lynley Gervasoni, Michelle Snell, Helen Shepherd, Philippa Harrison and Felicity Lawrence for their assistance in recruiting participants. Finally, the authors would like to thank everyone who took the time to participate in the study.

COMMENTS
Background

Anorexia nervosa (AN) is a psychiatric condition associated with perfectionism and rigid thinking patterns. Investigations of cognitive performance in AN have often focused on related measures. However, comprehensive assessments of cognition in AN have rarely been undertaken and findings have been inconsistent. Therefore, this study utilised a comprehensive cognitive battery to gain a better understanding of cognitive performance in AN.

Research frontiers

Individuals with AN appear to have largely intact cognitive function, but demonstrate difficulties with complex visuospatial processing.

Innovations and breakthroughs

Findings in acute AN have rarely utilised a comprehensive set of cognitive tasks and have consequently tended to report conflicting findings. Employing a comprehensive set of cognitive assessments in a group of medically stable patients with acute AN suggests that AN may not be associated with significant cognitive deficits, but with subtle difficulties in manipulating visuospatial information.

Applications

As only limited cognitive deficits were observed, they may arise from relatively restricted brain regions which may also be involved in the psychopathology of AN.

Peer-review

The research is interesting and the manuscript is well written.

Footnotes

P- Reviewer: Contreras CM, Liu-Seifert H, Richter J S- Editor: Ji FF L- Editor: A E- Editor: Jiao XK

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