In vitro Effectiveness of Acacia concinna Extract against Dermatomycotic Pathogens

doi:10.5530/pj.2011.19.13

Pharmacognosy Journal

Volume 3, Issue 19, January 2011, Pages 69-73

https://doi.org/10.5530/pj.2011.19.13 Get rights and content

Abstract

Acacia concinna (Wild.) D.C. is an important medicinal plant in Thailand and throughout Asian countries. Its dried pods are traditionally utilized as herbal medicine to treat many health symptoms e.g. laxative, cough, antidandruff and skin diseases. This investigation was performed in order to demonstrate the antimicrobial potential of different A. concinna extracts against the fungal causative agents of ringworm and opportunistic infections of immunocompromised populations. Phytochemical study showed that the crude extract of A. concinna pod consisted of alkaloids, flavonoids, saponin and tannin but none of antraquinone and cyanotic glycosides. The extracts e.g. ethanolic Soxhlet extract and chloroform extract from Soxhlet extractor, and lyophilized extract and macerated ethanolic extract were tested using diffusion method against 35 isolates of dermatophytes and each 20 isolates of Candida albicans, Cryptococcus neoformans and Penicillium marneffei. The inhibitory effects were observed by considering their average inhibitory zone diameter (IZD) compared to that of ketoconazole's. From the averaged IZDs of all fungal isolates, the antifungal effectiveness of lyophilized, chloroform, ethanolic (Soxhlet) and ethanolic (macerated) extract was at 18.38, 18.34, 16.67 and 14.06 mm, respectively.

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Citation Excerpt :
Phenolic content has been considered as one of the major phytochemicals and received much more attention due to their potential antioxidant properties, which involved in human health [31]. Tannin has been determined as the major phenolic compound in the Acacia pods [29]. Tannins have been used in various industrial processes as wood adhesives and leather tannins.
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In vitro Effectiveness of Acacia concinna Extract against Dermatomycotic Pathogens

Abstract

Current Problems in Dermatology

Int. J Med Microbiol

Infect Dis Clin North Am

The Lancet

J Ethnopharmacol

Medical mycology

Onychomycosis is more than a cosmetic problem

Br. J. Dermatol

Antidermatophytic activity of Acacia concinna

Global J of Pharmacol

Precision and accuracy of fluconazole susceptibility testing by broth microdilution, Etest, and disk diffusion methods

Antimicrob. Agents Chemother