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Home / The International Journal of Tuberculosis and Lung Disease, Volume 20, Number 4

Re-inventing adherence: toward a patient-centered model of care for drug-resistant tuberculosis and HIV

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BACKGROUND: Despite renewed focus on molecular tuberculosis (TB) diagnostics and new antimycobacterial agents, treatment outcomes for patients co-infected with drug-resistant TB and human immunodeficiency virus (HIV) remain dismal, in part due to lack of focus on medication adherence as part of a patient-centered continuum of care.

OBJECTIVE: To review current barriers to drug-resistant TB-HIV treatment and propose an alternative model to conventional approaches to treatment support.

DISCUSSION: Current national TB control programs rely heavily on directly observed therapy (DOT) as the centerpiece of treatment delivery and adherence support. Medication adherence and care for drug-resistant TB-HIV could be improved by fully implementing team-based patient-centered care, empowering patients through counseling and support, maintaining a rights-based approach while acknowledging the responsibility of health care systems in providing comprehensive care, and prioritizing critical research gaps.

CONCLUSION: It is time to re-invent our understanding of adherence in drug-resistant TB and HIV by focusing attention on the complex clinical, behavioral, social, and structural needs of affected patients and communities.

Keywords: HIV; drug-resistant TB; medication adherence; patient-centered care

Document Type: Research Article

Affiliations: 1: *Division of Pulmonary Allergy and Critical Care Medicine, Columbia University Medical Center, New York , †Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA, ‡Centre for the AIDS Programme of Research in South Africa, South African Medical Research Council TB HIV Pathogenesis Extramural Unit, Durban, South Africa 2: ‡Centre for the AIDS Programme of Research in South Africa, South African Medical Research Council TB HIV Pathogenesis Extramural Unit, Durban, South Africa, §Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada 3: Treatment Action Group, New York 4: †Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA, #International Center for AIDS Care and Treatment Programs, Mailman School of Public Health, Columbia University, New York, New York 5: Department of Health Behavior and Health Education, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA 6: ††University of Cape Town, Cape Town, South Africa 7: *Division of Pulmonary Allergy and Critical Care Medicine, Columbia University Medical Center, New York 8: ‡‡Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, USA 9: §§Médecins Sans Frontières, Mumbai, India 10: ##Touro College Graduate School of Social Work, New York, New York 11: ***Montefiore Medical Center & Albert Einstein College of Medicine, Bronx, New York 12: ‡Centre for the AIDS Programme of Research in South Africa, South African Medical Research Council TB HIV Pathogenesis Extramural Unit, Durban, South Africa 13: †††Harvard Medical School, Boston, Massachusetts 14: ¶¶Yale University School of Public Health, New Haven, Connecticut, ‡‡‡Yale University School of Medicine, New Haven, Connecticut, USA

Publication date: 01 April 2016

More about this publication?

  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

    The IJTLD is dedicated to understanding lung disease and to the dissemination of knowledge leading to better lung health. To allow us to share scientific research as rapidly as possible, the IJTLD is fast-tracking the publication of certain articles as preprints prior to their publication. Read fast-track articles.

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