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Home / The International Journal of Tuberculosis and Lung Disease, Volume 21, Number 7

Management of child MDR-TB contacts across countries in the WHO European Region: a survey of current practice

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The World Health Organization European Region has one of the highest rates of multidrug-resistant tuberculosis (MDR-TB) in the world, resulting in many vulnerable children being exposed each year. Evidence for preventive therapy following MDR-TB exposure is limited and current guidance is conflicting. An internet-based survey was performed to determine clinical practice in this region. Seventy-two clinicians from 25 countries participated. Practices related to screening and decision-making were highly variable. Just over half provided preventive therapy for children exposed to MDR-TB; the only characteristic associated with provision was practice within the European Union (adjusted OR 4.07, 95%CI 1.33–12.5).

Keywords: MDR-TB; chemoprophylaxis; paediatric; preventive treatment

Document Type: Research Article

Affiliations: 1: Medical Research Council Clinical Trials Unit at University College London, London, Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London 2: Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, Southampton Respiratory Biomedical Research Unit, Southampton University Hospital NHS Foundation Trust, Southampton, Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, UK 3: Department of Paediatric Pulmonology, Children's Hospital, Ruhr University Bochum, Bochum, Germany 4: Second University Department of Paediatrics, National and Kapodistrian University of Athens School of Medicine, ‘P. & A. Kyriakou' Children's Hospital, Athens, Greece 5: Department of Paediatrics, Centre Hospitalière Universitaire Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium 6: Medical Research Council Unit, The Gambia, Banjul, The Gambia, Centre for International Child Health, Department of Paediatrics, Imperial College London, London, UK 7: Centre for International Child Health, Department of Paediatrics, Imperial College London, London, UK

Publication date: 01 July 2017

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  • The International Journal of Tuberculosis and Lung Disease (IJTLD) is for clinical research and epidemiological studies on lung health, including articles on TB, TB-HIV and respiratory diseases such as COVID-19, asthma, COPD, child lung health and the hazards of tobacco and air pollution. Individuals and institutes can subscribe to the IJTLD online or in print – simply email us at [email protected] for details.

    The IJTLD is dedicated to understanding lung disease and to the dissemination of knowledge leading to better lung health. To allow us to share scientific research as rapidly as possible, the IJTLD is fast-tracking the publication of certain articles as preprints prior to their publication. Read fast-track articles.

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