Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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The Effects of Asiasarum Root Methanol Extract Fractions on the Cell Mediated and Humoral Immune Responses in Mice

족도리풀 뿌리의 메탄올엑스 분획이 마우스의 세포성 및 체액성 면역반응에 미치는 영향

  • Published : 2008.06.30
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Abstract

The effects of Asiasarum Root on the cell mediated and humoral immune responses were investigated in ICR mice. ICR mice received intraperitoneal injection of methanol extracts (ether fraction, butanol fraction, water fraction) for 5 days before sensitization. The change of body weight (%), the organ weight ratio (%), the numbers of RBC and WBC, the ear swelling by dinitrofluorobenzene, the titers of hemagglutination (HA) and hemolysin (HY) to SRBC were determined. The results were as follows; 1. The change of body weight (%) showed a tendency of increasing. 2. The weight of spleen (%) decreased. 3. Ear swelling was maximum at 48 hours after challenge and was significantly decreased in the groups. 4. The numbers of RBC and WBC were decreased. 5. HA and HY titers were decreased.

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References

  1. Kim, J . G. : I llustr ated N atur al D rugs E ncyclopedia (II), Seoul, Namsandang Press, 137, 1984
  2. Kim, C. M. : The Encyclopedia of Orietal Herbal Medicine (II), Seoul, Chungdam Press, 2388-2396, 1997
  3. The Korean Pharmacopeia 9th edition, Seoul, Shinilbooks Press, 939, 2008
  4. Kang, S . S. : Natural Products S ciences, Seoul. Snubook Press, 1-27, 1999
  5. Chae, Y. B. and Kim, H. J. : The research of Korean utilized plants. Korea Research Institute of Chemical Technology, Daejeon, 136, 1988
  6. Pharmacognosy Com. : Pharmacognosy, Seoul, Dmsbook Press, 151-153, 2008
  7. Rodriguez-Paez, L., Juarez-Sanchez, M., Antunez- Solis, J., Baeza, I. and Wong, C. : Alpha-asarone inhibits HMG-CoA reductase, lowers serum LDL-cholesterol levels and reduces biliary CSI in hypercholesterolemic rats. Phytomedicine 10(5), 397-404, 2003 https://doi.org/10.1078/0944-7113-00274
  8. Kim, D. K. : Herb Medicinal Pharmacognosy, Seoul, Shinilbooks Press, 57-58, 2007
  9. Johji Yamahara, Toshio Yamada, Hitoshi Kimura, Tokuniske Sawada, and Hajime Fujimura : Biologically active Principles of crude drugs, Anti allergic principles of 'Shoeseiryu-to' I. Effect on delayedtype Allergy reaction, Yakugaku Zasshi, 102, 881, 1982 https://doi.org/10.1248/yakushi1947.102.9_881
  10. Yumiko Nakano : Antigenic competition in the induction of contact sensitivity in mice. Immunology, 33(2), 167-178, 1977 https://doi.org/10.1016/S0065-2776(08)60836-6
  11. Sy, M. S., Miller, S. D. and Claman, H. N. : Immune suppression with supraoptimal doses of antigen in contact sensitivity. I. Demonstration of suppressor cells and their sensitivity to cyclophosphamide. The Journal of Immunology, 119(1), 240-244, 1977
  12. Miller, S. D., Sy, M. S. and Claman, H. N. : Suppressor T cell mechanisms in contact sensitivity. I. Efferent blockade by syninduced suppressor T cells. The Journal of Immunology, 121(1), 265-273, 1978
  13. Kameyama, S. and Kondo, S. : Titration of tetanus antitoxin by passive hemagglutination. I. Titration of guinea-pig antitoxins at various periods of immunization. Japanese Journal of Medical Science and Biology, 28(2), 127-138, 1975 https://doi.org/10.7883/yoken1952.28.127
  14. Park, J. Y. and Kim, N. J. : The effects of chelidonii herba extract on the cell mediate and humoral immune responses in mice. Korean Journal of Environmental Health, 31(1), 66-72, 2005
  15. Xu, J. and Hu, Q. : Effect of foliar application of selenium on the antioxidant activity of aqueous and ethanolic extracts of selenium-enriched rice. Journal of Agriculture Food Chemistry, 52, 1759-1768, 2004 https://doi.org/10.1021/jf0349836
  16. Han, Y. N. and Oh, H. K. : Antioxidant components of gardenia fruit. Korean Journal of Pharmacognosy, 25(3), 226-232, 1994
  17. Park, J. Y. and Kim, E. K. : The effect of Cichorium intybus extract on hepatotoxicity in rats. Korean Journal of Environmental Health, 32(3), 235-239, 2006
  18. Park, J. Y. : The effect of Petasites japonicus extract on hepatotoxicity in rats. Korean Journal of Environmental Health, 33(3), 202-206, 2007 https://doi.org/10.5668/JEHS.2007.33.3.202