Omalizumab in patients with severe asthma and persistent sputum eosinophilia
Posted on 2019-04-03 - 05:00
Abstract Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who remain uncontrolled despite high dose inhaled corticosteroid and bronchodilators. Steroid-sparing effect of omalizumab has not been demonstrated in asthmatics with persistent airway eosinophilia in a randomised controlled trial till date. From this double-blind, placebo-controlled, multi-centred, randomized parallel group design, we report that omalizumab is possibly inadequate to control sputum eosinophilia, and therefore may not have a steroid-sparing effect, especially in those maintained on oral corticosteroids daily. This needs to be confirmed or refuted in a larger trial, which may be a challenge with respect to recruitment, since there are currently three additional biologics available to prescribe. Trial registration Clinicaltrials.gov, NCT02049294, Registered 30th January 2014, https://clinicaltrials.gov/ct2/show/NCT02049294
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Mukherjee, Manali; Kjarsgaard, Melanie; Radford, Katherine; Huang, Chynna; Leigh, Richard; Dorscheid, Delbert; et al. (2019). Omalizumab in patients with severe asthma and persistent sputum eosinophilia. figshare. Collection. https://doi.org/10.6084/m9.figshare.c.4459229.v1