1976 Volume 29 Issue 2 Pages 125-131
Derivatives of pleuromutilin, formed during the fermentation of pleuromutilin. were isolated and their structure determined. 14-Acetyl-mutilin and mutilin as well as different unsaturated fatty acid esters of pleuromutilin were identified. The proportion of each derivative formed depends to a considerable degree on the conditions of the fermentation process. The possible biosynthetic pathways are shown.