The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
TALLYSOMYCIN, A NEW ANTITUMOR ANTIBIOTIC COMPLEX RELATED TO BLEOMYCIN
I. PRODUCTION, ISOLATION AND PROPERTIES
HIROSHI KAWAGUCHI, HIROSHI TSUKIURA, KOJI TOMITA, MASATAKA KONISHI, KYO-ICHIRO SAITO, SEIKICHI KOBARU, KEI-ICHI NUMATA, KEI-ICHI FUJISAWA, TAKEO MIYAKI, MASAMI HATORI, HIDEO KOSHIYAMA
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1977 Volume 30 Issue 10 Pages 779-788

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Abstract

The unusual actinomycetes strain No. E465-94 produced a complex of new glycopeptide antibiotics tallysomycin, which was separated by CM-Sephadex chromatography into two major components, A (C68H107N21O27S2) and B (C62H95N19O26S2). They were isolated first in a copperchelated form and showed physico-chemical properties similar to those of the bleomycingroup of antibiotics. Tallysomycin exhibited broad antibacterial and antifungal activity, and was highly active in vivo against bacterial infections in mice. Tallysomycins A and B demonstrated potent activity in the prophage induction of lysogenic bacteria.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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