The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
ISOLATION AND CHARACTERIZATION OF ANTIBIOTIC X-14547A, A NOVEL MONOCARBOXYLIC AClD IONOPHORE PRODUCED BY STREPTOMYCES ANTIBIOTICUS NRRL 8167
JOHN W. WESTLEYRALPH H. EVANS Jr.LILIAN H. SELLONELSON TROUPE
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1979 Volume 32 Issue 2 Pages 100-107

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Abstract

A novel carboxylic acid ionophore, antibiotic X-14547A, closely related to the polyether antibiotics has been isolated along with four other metabolites from fermented cultures of a new strain of Streptomyces antibioticus. The structure, determined by X-ray analysis of the R(+)-1-amino-1-(4-bromophenyl)-ethane salt contained pyrrole carbonyl and trans-butadienyl chromophores in addition to the unusual tetrahydroindane bicyclic ring system. A second novel metabolite was identified as 3-ethyl-1, 3-dihydro-3-methoxy-2H-indol-2-one.

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© Japan Antibiotics Research Association
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