DIHYDROMEVINOLIN, A POTENT HYPOCHOLESTEROLEMIC METABOLITE PRODUCED BY ASPERGILLUS TERREUS

G. ALBERS-SCHÖNBERG; H. JOSHUA; M. B. LOPEZ; O. D. HENSENS; J. P. SPRINGER; J. CHEN; S. OSTROVE; C. H. HOFFMAN; A. W. ALBERTS; A. A. PATCHETT

doi:10.7164/antibiotics.34.507

DIHYDROMEVINOLIN, A POTENT HYPOCHOLESTEROLEMIC METABOLITE PRODUCED BY ASPERGILLUS TERREUS

G. ALBERS-SCHÖNBERG, H. JOSHUA, M. B. LOPEZ, O. D. HENSENS, J. P. SPRINGER, J. CHEN, S. OSTROVE, C. H. HOFFMAN, A. W. ALBERTS, A. A. PATCHETT

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G. ALBERS-SCHÖNBERG
Merck Sharp & Dohme Research Laboratories
H. JOSHUA
Merck Sharp & Dohme Research Laboratories
M. B. LOPEZ
Merck Sharp & Dohme Research Laboratories
O. D. HENSENS
Merck Sharp & Dohme Research Laboratories
J. P. SPRINGER
Merck Sharp & Dohme Research Laboratories
J. CHEN
Merck Sharp & Dohme Research Laboratories
S. OSTROVE
Merck Sharp & Dohme Research Laboratories
C. H. HOFFMAN
Merck Sharp & Dohme Research Laboratories
A. W. ALBERTS
Merck Sharp & Dohme Research Laboratories
A. A. PATCHETT
Merck Sharp & Dohme Research Laboratories

JOURNAL FREE ACCESS

1981 Volume 34 Issue 5 Pages 507-512

DOI https://doi.org/10.7164/antibiotics.34.507

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Abstract

A new, potent hypocholesterolemic agent is produced by cultures of Aspergillus terreus. The isolation of the compound and its characterization as 4a, 5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for dihydromevinolin and mevinolin in three biological assays are given: in vitro inhibition of HMG-CoA reductase, inhibition of sterol synthesis in cell cultures, and inhibition of cholesterol synthesis in vivo in rats.

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