FR-900520 AND FR-900523, NOVEL IMMUNOSUPPRESSANTS ISOLATED FROM A STREPTOMYCES II. FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERISTICS

HIROSHI HATANAKA; TOHRU KINO; SUSUMU MIYATA; NORIAKI INAMURA; AKIO KURODA; TOSHIO GOTO; HIROKAZU TANAKA; MASAKUNI OKUHARA

doi:10.7164/antibiotics.41.1592

FR-900520 AND FR-900523, NOVEL IMMUNOSUPPRESSANTS ISOLATED FROM A STREPTOMYCES

II. FERMENTATION, ISOLATION AND PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERISTICS

HIROSHI HATANAKA, TOHRU KINO, SUSUMU MIYATA, NORIAKI INAMURA, AKIO KURODA, TOSHIO GOTO, HIROKAZU TANAKA, MASAKUNI OKUHARA

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JOURNAL FREE ACCESS

1988 Volume 41 Issue 11 Pages 1592-1601

DOI https://doi.org/10.7164/antibiotics.41.1592

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Abstract

FR-900520 and FR-900523, novel neutral macrolide immunosuppressants, were isolated from the cultured broth of Streptomyces hygroscopicus subsp. yakushimaensis No. 7238. Their molecular formulae were determined as C₄₃H₆₉NO₁₂ and C₄₂H₆₇NO₁₂, respectively. The compounds suppressed immune response in vitro. IC₅₀ values of FR-900520 and FR900523 for mouse mixed lymphocyte reaction were 0.55 nM and 1.6nM, respectively. FR900520, the major component, clealy prolonged skin allograft survival in rats.

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