LANTHIOPEPTIN, A NEW PEPTIDE ANTIBIOTIC PRODUCTION, ISOLATION AND PROPERTIES OF LANTHIOPEPTIN

NOBUAKI NARUSE; OSAMU TENMYO; KOJI TOMITA; MASATAKA KONISHI; TAKEO MIYAKI; HIROSHI KAWAGUCHI; KOICHI FUKASE; TATEAKI WAKAMIYA; TETSUO SHIBA

doi:10.7164/antibiotics.42.837

LANTHIOPEPTIN, A NEW PEPTIDE ANTIBIOTIC

PRODUCTION, ISOLATION AND PROPERTIES OF LANTHIOPEPTIN

NOBUAKI NARUSE, OSAMU TENMYO, KOJI TOMITA, MASATAKA KONISHI, TAKEO MIYAKI, HIROSHI KAWAGUCHI, KOICHI FUKASE, TATEAKI WAKAMIYA, TETSUO SHIBA

Author information

NOBUAKI NARUSE
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
OSAMU TENMYO
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
KOJI TOMITA
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
MASATAKA KONISHI
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
TAKEO MIYAKI
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
HIROSHI KAWAGUCHI
Bristol-Myers Research Institute, Ltd., Tokyo Research Center
KOICHI FUKASE
Department of Chemistry, Faculty of Science, Osaka University
TATEAKI WAKAMIYA
Department of Chemistry, Faculty of Science, Osaka University
TETSUO SHIBA
Peptide Institute, Protein Research Foundation, Minoh

JOURNAL FREE ACCESS

1989 Volume 42 Issue 6 Pages 837-845

DOI https://doi.org/10.7164/antibiotics.42.837

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Abstract

A strain of Streptoverticillium dnnamoneum produced a peptide antibiotic named lanthiopeptin, which contained four unusual amino acids, erythro-β-hydroxyaspartic acid, meso-lanthionine, threo-β-methyllanthionine and lysinoalanine. Lanthiopeptin showed antiviral activity against herpes simplex virus type 1 KOS strain infection in Vero cells by cytopathic effect reduction assay. The structure of lanthiopeptin is similar to that of ancovenin.

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