NF00659A1, A2, A3, B1 and B2, Novel Antitumor Antibiotics Produced by Aspergillus sp. NF 00659 I. Taxonomy, Fermentation, Isolation and Biological Activities

KATSUHIRO SUZUKI; ATSUSHI KUWAHARA; HIROSHI YOSHIDA; SHINJI FUJITA; TAKAAKI NISHIKIORI; TAIZO NAKAGAWA

doi:10.7164/antibiotics.50.314

NF00659A₁, A₂, A₃, B₁ and B₂, Novel Antitumor Antibiotics Produced by Aspergillus sp. NF 00659

I. Taxonomy, Fermentation, Isolation and Biological Activities

KATSUHIRO SUZUKI, ATSUSHI KUWAHARA, HIROSHI YOSHIDA, SHINJI FUJITA, TAKAAKI NISHIKIORI, TAIZO NAKAGAWA

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JOURNAL FREE ACCESS

1997 Volume 50 Issue 4 Pages 314-317

DOI https://doi.org/10.7164/antibiotics.50.314

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Abstract

Five novel cytotoxic antibiotics, NF00659A₁ (1), A₂(2), A₃(3), B₁(4) and B₂(5) were discovered. They were isolated from a culture mycelium of Aspergillus sp. These compounds were proved to have 4, 5-seco-tricyclic diterpene α-pyrone structure by spectroscopic analyses. They showed potent antitumor activities against human ovarian carcinoma A2780 and human colorectal adenocarcinoma SW480 cells, but did not show any antimicrobial activities at 1, 000μg/ml against Gram-positive and Gram-negative bacteria, yeasts and fungi.

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